Biomolecules, 2020 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder manifesting with upper and lower neuron loss, leading to impairments in voluntary muscle function and atrophy.
Merina Varghese +3 more
doaj +1 more source
PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
Molecular Metabolism, 2018 Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1.
Jaemin Lee +5 more
doaj +1 more source
Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury
Neural Plasticity, 2022 Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis.
Bin Han +6 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Atherosclerosis (AS) is the main cause of morbidity and mortality in the world. Mitochondrial dysfunction is closely related to AS. At present, several signaling pathways related to mitochondrial dysfunction have been found, one of which is around PGC-1α.
Guiming Wang +6 more
doaj +1 more source
PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts [PDF]
Genetics and Molecular Biology, 2020 The XPC protein, which is mutated in xeroderma pigmentosum (XP) complementation group C (XP-C), is a lesion recognition factor in NER, but it has also been shown to interact with and stimulate DNA glycosylases, to act as transcriptional co-activator and ...
Mateus Prates Mori +1 more
doaj +1 more source
PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator
Cells, 2020 Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function.
Joseph M. Chambers, Rebecca A. Wingert
doaj +1 more source
PGC-1α determines light damage susceptibility of the murine retina. [PDF]
PLoS ONE, 2012 The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand.
Anna Egger +13 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α. [PDF]
PLoS ONE, 2015 Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors whose expression increases in the skeletal muscle during exercise.
Yukino Hatazawa +6 more
doaj +1 more source
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. [PDF]
PLoS ONE, 2011 BackgroundThiazolidinediones, a family of insulin-sensitizing drugs commonly used to treat type 2 diabetes, are thought to exert their effects in part by promoting mitochondrial biogenesis in white adipose tissue through the transcriptional coactivator ...
Rosario Pardo +5 more
doaj +1 more source