MicroRNA Regulation of SIRT1 [PDF]
Frontiers in Physiology, 2012 SIRT1 is an NAD-dependent deacetylase that regulates stress response pathways. By deacetylating transcription factors and co-factors, SIRT1 modulates metabolism, inflammation, hypoxic responses, circadian rhythms, cell survival, and longevity. Since SIRT1 plays a key role in regulating pathways involved in cardiovascular diseases and metabolic diseases
Munekazu Yamakuchi, Yamakuchi Munekazu
exaly +5 more sources
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
Open Biology, 2013 The NAD + -dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies.
Knight, J.R.P. +2 more
openaire +11 more sources
Rejuvenating SIRT1 Activators [PDF]
Cell Metabolism, 2013 Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.
Gut, Philipp, Verdin, Eric
openaire +4 more sources
LncRNA Sirt1-AS Protects Against Cardiac Hypertrophy by Modulating Sirt1 [PDF]
Journal of Cardiovascular Pharmacology and TherapeuticsBackground LncRNAs are pivotal regulators in cardiovascular diseases. Sirt1-AS, a lncRNA, has been shown to play a role in cardiovascular diseases. This study aimed to explore the role of Sirt1-AS in cardiac hypertrophy and the underlying molecular mechanism.
Xuejiao Wei +5 more
openaire +3 more sources
Ursolic acid protects the kidneys from the consequences of aging through increasing the expression of SIRT1, SIRT6 and α-Klotho in the mice model [PDF]
World Cancer Research Journal, 2021 Objective: In our previous studies on the anti-aging effects of ursolic acid (UA) on various tissues including skeletal muscle, heart, hypothalamus and pancreas, the protective and anti-aging roles of UA on renal tissue remained elusive.
M. Rezaei, N. Bakhtiari
doaj +1 more source
Association between The SIRT1 and SIRT3 Levels and Gene Polymorphisms with Infertility in War Zones of Kermanshah Province, Iran: A Case-Control Study [PDF]
International Journal of Fertility and Sterility, 2023 Objective: War toxin, mustard gas, alkylating agent results in male infertility via inducing reactive oxygen species (ROS) production and DNA mutagenesis.
Abolfazl Nasiri +3 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 SIRT1 was discovered in 1979 but growing interest in this protein occurred only 20 years later when its overexpression was reported to prolong the lifespan of yeast.
Zsuzsanna Nemeth +2 more
doaj +1 more source
PRIMARY INFERTILITY, OXIDATIVE STRESS AND METFORMIN; IMPACT ON PRIMARY HUMAN GRANULOSA CELL CULTURES
Khyber Medical University Journal, 2021 OBJECTIVE: To observe the effect of metformin on oxidative stress (OS) levels and SIRT1 expression in primary human granulosa cell cultures from infertile females.
Faiza Alam +4 more
doaj +1 more source
Laminar Shear Stress Protects Against Premature Endothelial Senescence by SIRT1-Dependent Mechanisms [PDF]
운동과학, 2021 s PURPOSE Accumulation of senescent endothelial cells (ECs) and development of vascular aging have been implicated in the etiology of vascular dysfunction and disease.
Ji-Seok Kim +3 more
doaj +1 more source
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway
Renal Failure, 2021 Sepsis-induced acute kidney injury (AKI) continues to be associated with poor outcomes in critical care patients. Previous research has revealed that tetrahydrocurcumin (THC) exerts renoprotective effects in multiple nephritic disorders by modulating ...
Lu Li +6 more
doaj +1 more source