Results 31 to 40 of about 72,220 (305)
SIRT1-MKO mice have mild dystrophic pathology. [PDF]
, 2019 (a) Immunofluorescence staining for SIRT1 (ab110304, Abcam), dystrophin, caveolin 3 and nNOS in muscle sections from WT mice at 6 months of age. Cytoplasm of skeletal muscles was stained with phalloidin.
Rio Sebori (6883070) +6 more
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Malang Neurology Journal, 2022 Background: Neurodegenerative diseases are the main cause of morbidity and disability in the elderly. SIRT1 activation has been gaining popularity as novel treatment target. Cinnamon is known to possess neuroprotective abilities, however the mechanism in
Umi Kalsum +7 more
doaj +1 more source
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]
, 2015 © 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong +35 more
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AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator [PDF]
Molecular Cell, 2007 SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
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SIRT1-MKO mice have muscle fragility with reduced exercise endurance and strength. [PDF]
, 2019 (a, b) Treadmill activity of WT and SIRT1-MKO mice at 3 months of age (a: n = 12) and 30 months of age (b: n = 6). (c) Hanging time after treadmill exercise of WT and SIRT1-MKO mice at 12 months of age (n = 6). (d) Grasping power of WT and SIRT1-MKO mice
Rio Sebori (6883070) +6 more
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Journal of Applied Poultry Research, 2021 Summary: To explore the role of insulin and forkhead box protein O1 (FoxO1) on cell proliferation regulated by sirtuin 1 (Sirt1) in goose primary hepatocyte, goose primary hepatocytes were isolated and incubated with Sirt1 inhibitor and nicotinamide, and
Rongxue Wei +9 more
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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Jo Milner +4 more
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The Roles of SIRT1 in Cancer [PDF]
Genes & Cancer, 2013 The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in ...
Zhenghong, Lin, Deyu, Fang
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Identification of novel mechanisms regulating the NAD+ -dependent deacetylase SIRT1 [PDF]
, 2007 Sirtuins comprise a highly conserved protein family which catalyse the deacetylation of proteins in an NAD+-dependent manner. In S. cerevisiae and in C.
Anastasiou, Dimitrios
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Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury [PDF]
, 2023 Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose-dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing the patient's ...
Wang, Yueying +9 more
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