Results 31 to 40 of about 77,206 (307)

Neurogenesis directed by Sirt1 [PDF]

Nature Cell Biology, 2008
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1.
Sergiy, Libert, Dena, Cohen, Leonard, Guarente   +2 more
openaire   +2 more sources

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
core   +1 more source

NEUROPROTECTIVE EFFECT OF CINNAMON ACTIVE COMPOUNDS VIA ACTIVATION OF SIRT1: A MOLECULAR DOCKING APPROACH

Malang Neurology Journal, 2022
Background: Neurodegenerative diseases are the main cause of morbidity and disability in the elderly. SIRT1 activation has been gaining popularity as novel treatment target. Cinnamon is known to possess neuroprotective abilities, however the mechanism in
Umi Kalsum, Husnul Khotimah, Nurfaizah Titisari Sulihah, Theakirana Firdaus, Fitrah Aulia Lisabilla, Editya Fukata, Happy Kurnia Permatasari, Sri Andarini   +7 more
doaj   +1 more source

Supplementary Material for: Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPKα-SIRT1-PGC-1α Pathway

, 2022
Introduction: Our previous studies have demonstrated advanced glycation end products (AGEs) was an important mediator in osteoarthritis (OA) which may induce mitochondrial dysfunction.
Yang Q. (4154716), Wu S. (3601439), Jin T. (4174513), Shi Y. (4122922), Duan B. (12188873)   +4 more
core   +1 more source

AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator [PDF]

Molecular Cell, 2007
SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
openaire   +2 more sources

Role of forkhead box protein O1 and insulin on cell proliferation mediated by sirtuin 1 in goose primary hepatocytes

Journal of Applied Poultry Research, 2021
Summary: To explore the role of insulin and forkhead box protein O1 (FoxO1) on cell proliferation regulated by sirtuin 1 (Sirt1) in goose primary hepatocyte, goose primary hepatocytes were isolated and incubated with Sirt1 inhibitor and nicotinamide, and
Rongxue Wei, Chunchun Han, Fang He, Xiangping Xiong, Fengjiang Ye, Hehe Liu, Liang Li, Hongyong Xu, Shouhai Wei, Xianyin Zeng   +9 more
doaj   +1 more source

Identification of novel mechanisms regulating the NAD+ -dependent deacetylase SIRT1 [PDF]

, 2007
Sirtuins comprise a highly conserved protein family which catalyse the deacetylation of proteins in an NAD+-dependent manner. In S. cerevisiae and in C.
Anastasiou, Dimitrios
core   +1 more source

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

, 2013
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Jo Milner, Simon J Allison, Milner, J., Allison, Simon J., Milner, Jo   +4 more
core   +1 more source

Artesunate reduces sepsis-mediated acute lung injury in a SIRT1-dependent manner [PDF]

BioImpacts, 2023
Introduction: Sepsis-mediated acute lung injury (ALI) is a critical clinical condition. Artesunate (AS) is a sesquiterpene lactone endoperoxide that was discovered in Artemisia annua, which is a traditional Chinese herb.
Zhaohui Liu, Yanli Meng, Yu Miao, Lili Yu, Qiannan Yu   +4 more
doaj   +1 more source

The Roles of SIRT1 in Cancer [PDF]

Genes & Cancer, 2013
The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in ...
Zhenghong, Lin, Deyu, Fang
openaire   +2 more sources