Results 1 to 10 of about 27,568,409 (275)

Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis [PDF]

iScience
Summary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation.
Runhua Du, Yanmei Gao, Cong Yan, Xuelian Ren, Shankang Qi, Guobin Liu, Xinlong Guo, Xiaohan Song, Hanmin Wang, Jingxin Rao, Yi Zang, Mingyue Zheng, Jia Li, He Huang   +13 more
doaj   +5 more sources

Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1

Frontiers in Endocrinology, 2022
The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality.
Jiayi Yan, Jue Wang, John Cijiang He, Yifei Zhong   +3 more
doaj   +4 more sources

Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes

International Journal of Molecular Sciences, 2023
Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants.
JOSÉ Pedraza-Chaverri, Mirna Ruiz Ramos, BEATRIZ Isabel Garcia-Martinez   +2 more
exaly   +2 more sources

Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction

Neural Regeneration Research, 2021
In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wang   +5 more
doaj   +2 more sources

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

Frontiers in Physiology, 2021
Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions.
Stefano Ministrini, Stefano Ministrini, Yustina M. Puspitasari, Georgia Beer, Luca Liberale, Luca Liberale, Fabrizio Montecucco, Fabrizio Montecucco, Giovanni G. Camici, Giovanni G. Camici, Giovanni G. Camici   +10 more
doaj   +2 more sources

Sirtuin 1 in Host Defense during Infection

Cells, 2022
Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of
Jin Kyung Kim, Prashanta Silwal, Eun-Kyeong Jo   +2 more
doaj   +2 more sources

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Cells, 2021
Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental ...
Angelika Bielach-Bazyluk, Edyta Zbroch, Hanna Mysliwiec, Alicja Rydzewska-Rosolowska, Katarzyna Kakareko, Iwona Flisiak, Tomasz Hryszko   +6 more
doaj   +2 more sources

Sirtuin 1 and Hormonal Regulations in Aging

Applied Sciences
Aging affects the structure and functions of all organs and systems in the organism. In the elderly, significant changes in hormonal levels are observed.
Milena Keremidarska-Markova, Iliyana Sazdova, Mitko Mladenov, Bissera Pilicheva, Plamen Zagorchev, Hristo Gagov   +5 more
doaj   +2 more sources

Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2′-deoxyguanosine levels in healthy smokers: A case–control study [PDF]

Journal of International Medical Research
Objectives This case–control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine in healthy ...
Samar Sultan
doaj   +2 more sources

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling [PDF]

Scientific Reports
Impaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear.
Mi Kyoung Seo, Jung Goo Lee, Ji Hyun Kim, Dae-Hyun Seog, Sehoon Jeong, Seong-Ho Kim, Jin Young Lee, Sung Woo Park   +7 more
doaj   +2 more sources