Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2′-deoxyguanosine levels in healthy smokers: A case–control study [PDF]
Journal of International Medical ResearchObjectives This case–control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine in healthy ...
Samar Sultan
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Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis [PDF]
iScienceSummary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation.
Runhua Du +13 more
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SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling [PDF]
Scientific ReportsImpaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear.
Mi Kyoung Seo +7 more
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Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients — a comparative study [PDF]
Cardiology JournalBACKGROUND: Studies of animal and human aortic tissue samples showed that sirtuins may protect against aortic aneurysm (AA). However, to date, no studies have assessed plasma or serum sirtuin levels in humans.
Jan Krekora +8 more
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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD [PDF]
Frontiers in EndocrinologyIntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation.
Yao Xu +11 more
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Examining Sirtuin-1 Levels and Inflammation Markers in Behcet's Disease: A Pilot Study [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: Assess circulatory Sirtuin-1 (SIRT1) levels in Behcet's disease (BD) and relationships with disease activity and inflammatory markers. Materials and Methods: Forty BD patients and 40 matched controls.
Volkan Ecesoy +4 more
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Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1
Frontiers in Endocrinology, 2022 The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality.
Jiayi Yan +3 more
doaj +1 more source
Neural Regeneration Research, 2021 In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang +5 more
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Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
Exploration of Medicine, 2020 Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways.
Fatiha Nassir
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(+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter type 4 (GLUT-4) of (+)-catechin & proanthocyanidin fraction Uncaria ...
Silvy Arundita +3 more
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