Results 11 to 20 of about 29,404,575 (242)

Sirtuin 1: A Dilemma in Transplantation

Journal of Transplantation, 2020
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar   +4 more
doaj   +2 more sources

Sirtuin 1 Levels in Recurrent Implantation Failure [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2017
Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF).
Yaprak Engin-Ustun, A. Seval Ozgu-Erdinc, Emel Kiyak Caglayan, Cavidan Gulerman, Esma Sarikaya, Ayla Aktulay, Canan Demirtas, Salim Erkaya, Nafiye Yilmaz   +8 more
doaj   +2 more sources

Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer [PDF]

Jurnal Kesehatan Andalas, 2023
Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation.
Havina Nurul Aizah, Amel Yanis, Hirowati Ali, Tofrizal Tofrizal, Cimi Ilmiawati, Dessy Arisanty   +5 more
doaj   +4 more sources

Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition.

PLoS ONE, 2014
Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death.
Cindy Gueguen, Bruno Palmier, Michel Plotkine, Catherine Marchand-Leroux, Valérie C Besson   +4 more
doaj   +2 more sources

Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period

Metabolites, 2021
Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life.
Kristina Hase, Laura Stahmer, Hadeel Shammas, Corinna Peter, Bettina Bohnhorst, Anibh Martin Das   +5 more
doaj   +2 more sources

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

mBio, 2019
Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral
Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry   +8 more
doaj   +2 more sources

Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein [PDF]

Life, 2023
Sirtuins are NAD+-dependent protein lysine deacylases implicated in metabolic regulation and aging-related dysfunctions. The nuclear isoform Sirt1 deacetylates histones and transcription factors and contributes, e.g., to brain and immune cell functions ...
Ramona S. Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M. Wöhrl, Clemens Steegborn   +7 more
doaj   +2 more sources

The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas [PDF]

Haseki Tıp Bülteni
Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and
Fatma Cakmak Kazanci, Nagehan Barisik Ozdemir, Sibel Sensu, Cem Cahit Barisik   +3 more
doaj   +2 more sources

Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1

Renal Failure, 2019
Background: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there is an urgent need to identify therapeutic targets to control the progression of cardiovascular disease.
Yingjie Liu, Yiru Wu, Zongli Diao, Weikang Guo, Wenhu Liu   +4 more
doaj   +2 more sources

Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients

Arquivos Brasileiros de Cardiologia, 2019
Background: Sirtuins may act in many cellular processes like apoptosis, DNA repair and lipid/glucose metabolism. Experimental studies suggested some sirtuin types may have protective effects against endothelial dysfunction, atherosclerosis, cardiac ...
Emrullah Kızıltunç, Arzu Kösem, Can Özkan, Burcu Uğurlu Ilgın, Harun Kundi, Mustafa Çetin, Ender Ornek   +6 more
doaj   +2 more sources