Results 11 to 20 of about 27,568,409 (275)

Role of sirtuin-1 in diabetic nephropathy [PDF]

Journal of Molecular Medicine, 2019
Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed ...
Weixia Sun, Chaosheng Lu, Lu Cai
exaly   +4 more sources

Sirtuin 1: A Dilemma in Transplantation [PDF]

Journal of Transplantation, 2020
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar   +4 more
doaj   +4 more sources

The Role of Sirtuin 1 (SIRT1) in Neurodegeneration

Cureus, 2023
Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic pathways and play a role in several disease processes. Of the seven mammalian homologs currently identified, sirtuin 1 (SIRT1) is the best understood and most studied ...
Daniel I Razick, Muzammil Akhtar, Jimmy Wen, Meraj Alam, Nabeal Dean, Muhammad Karabala, Ubaid Ansari, Zaid Ahmad Ansari, Ethan Tabaie, Shakeel Siddiqui   +9 more
semanticscholar   +3 more sources

Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1

Cellular and Molecular Life Sciences, 2021
Chronic disruption of circadian rhythms which include intricate molecular transcription–translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology.
S. Soni, Priyoneel Basu, M. Singaravel, Ramaswamy Sharma, S. Pandi‑Perumal, D. Cardinali, R. Reiter   +6 more
semanticscholar   +4 more sources

Sirtuin 1 Levels in Recurrent Implantation Failure [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2017
Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF).
Yaprak Engin-Ustun, A. Seval Ozgu-Erdinc, Emel Kiyak Caglayan, Cavidan Gulerman, Esma Sarikaya, Ayla Aktulay, Canan Demirtas, Salim Erkaya, Nafiye Yilmaz   +8 more
doaj   +8 more sources

Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients — a comparative study [PDF]

Cardiology Journal
BACKGROUND: Studies of animal and human aortic tissue samples showed that sirtuins may protect against aortic aneurysm (AA). However, to date, no studies have assessed plasma or serum sirtuin levels in humans.
Jan Krekora, Oliwia Matuszewska-Brycht, Jolanta Fryczak, Piotr Stępiński, Michał Krejca, Agnieszka Siejka, Daria Kaczmarek, Piotr Merks, Jarosław Drożdż   +8 more
doaj   +2 more sources

Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Pharmacological Research
Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes.
Zhihao Liao, Xuepei Cai, Yifan Zheng, Jiayu Lin, Xia Yang, Weiyin Lin, Ying Zhang, Xin He, Chufeng Liu   +8 more
doaj   +2 more sources

Renal Protective Effect of Sirtuin 1 [PDF]

Journal of Diabetes Research, 2014
Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD+-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied.
Yi-jun Dong, Nian Liu, Zhi Xiao, Tao Sun, Shu-hui Wu, Wei-xia Sun, Zhong-gao Xu, Hang Yuan   +7 more
doaj   +3 more sources

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD [PDF]

Frontiers in Endocrinology
IntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation.
Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan   +11 more
doaj   +2 more sources

Examining Sirtuin-1 Levels and Inflammation Markers in Behcet's Disease: A Pilot Study [PDF]

The Turkish Journal of Gastroenterology
Background/Aims: Assess circulatory Sirtuin-1 (SIRT1) levels in Behcet's disease (BD) and relationships with disease activity and inflammatory markers. Materials and Methods: Forty BD patients and 40 matched controls.
Volkan Ecesoy, Hasan Arıcı, Fadime Pınar Ateş, Usame Ömer Osmanoğlu, Hilal Ecesoy   +4 more
doaj   +2 more sources