Results 21 to 30 of about 27,568,409 (275)

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

Developmental Cell, 2019
SUMMARY The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triplenegative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the ...
Marc Antonyak, Lu Ling, Hening Lin
exaly   +2 more sources

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]

International Journal of Molecular Sciences, 2021
Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid, Kim-Gwendolyn Dietrich, Ignasi Forne, Alexander Burges, Magdalena Szymanska, Rina Meidan, Doris Mayr, Artur Mayerhofer   +7 more
openaire   +2 more sources

Sirtuin 1 and Sirtuin 2 Gene Expressions in Colorectal Cancers. [PDF]

J Clin Pract Res
This study aimed to evaluate the immunoreactivity of sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) in colorectal cancer tissues using immunohistochemistry and to investigate their potential roles in the diagnosis and prognosis of colorectal cancer.Colon specimens from 104 patients diagnosed with colorectal adenocarcinoma at SBÜ Kartal Dr.
Düzenli T, Doğan D, Barışık NÖ.
europepmc   +5 more sources

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]

Physiological Reviews, 2012
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Ruben, Nogueiras, Kirk M, Habegger, Nilika, Chaudhary, Brian, Finan, Alexander S, Banks, Marcelo O, Dietrich, Tamas L, Horvath, David A, Sinclair, Paul T, Pfluger, Matthias H, Tschöp   +9 more
openaire   +4 more sources

Sirtuin 1 and endothelial glycocalyx [PDF]

Pflügers Archiv - European Journal of Physiology, 2020
AbstractSirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of ...
Lipphardt, Mark, Song, Jong Wook, Goligorsky, Michael S, Lipphardt, Mark; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany, Song, Jong Wook; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea, Goligorsky, Michael S; Renal Research Institute, New York Medical College at the Touro University, Valhalla, USA   +5 more
openaire   +4 more sources

A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence

Journal of Alzheimer's disease reports, 2023
Sirtuin-1 (Sirt1), encoded by the SIRT1 gene, is a conserved Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase enzyme, considered as the master regulator of metabolism in humans.
M. Mehramiz, T. Porter, E. O’Brien, S. Rainey-Smith, Simon M. Laws   +4 more
semanticscholar   +1 more source

Dapagliflozin prevents oxidative stress-induced endothelial dysfunction via sirtuin 1 activation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Recent studies have demonstrated that dapagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, prevents endothelial dysfunction; however, direct effects of dapagliflozin on the endothelium under oxidative stress and the underlying ...
Ying Zhou, Shinji Tai, Ningjie Zhang, Liyao Fu, Yongjun Wang   +4 more
semanticscholar   +1 more source

The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta

International Journal of Molecular Sciences, 2023
Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes.
M. Wątroba, G. Szewczyk, D. Szukiewicz
semanticscholar   +1 more source

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death

Redox Biology, 2022
Sirtuin-1 (SIRT1) is a critical nuclear deacetylase that participates in a wide range of biological processes. We hereby employed quantitative acetyl-proteomics to globally reveal the landscape of SIRT1-dependent acetylation in colorectal cancer (CRC ...
Yue Sun, Yan-ming Yang, Yuyang Hu, Lan Ouyang, Zhenghua Sun, Xingfeng Yin, Nan Li, Qing-Yu He, Yang Wang   +8 more
semanticscholar   +1 more source

Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3

Exploration of Medicine, 2020
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways.
Fatiha Nassir
doaj   +1 more source