Results 31 to 40 of about 27,568,409 (275)

SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1

Cellular & Molecular Immunology, 2022
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome (ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major players in ARDS development during respiratory virus infections.
Shilei Zhang, Jingfeng Wang, Lulan Wang, Saba R. Aliyari, G. Cheng   +4 more
semanticscholar   +1 more source

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

Nature Communications, 2022
Trans-activation response DNA-binding protein of 43  kDa (TDP-43) regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, R. Feederle, Simon J. Elsässer, Angelos A. Skodras, C. Gloeckner, E. Buratti, Manuela Neumann, P. Kahle   +9 more
semanticscholar   +1 more source

(+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter type 4 (GLUT-4) of (+)-catechin & proanthocyanidin fraction Uncaria ...
Silvy Arundita, Friardi Ismed, Rauza Sukma Rita, Deddi Prima Putra   +3 more
doaj   +1 more source

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

Biomedicines, 2021
The signaling pathways involved in age-related inflammation are increasingly recognized as targets for the development of preventive and therapeutic strategies.
Cátia Sousa, Bruno Miguel Neves, Alcino Jorge Leitão, Alexandrina Ferreira Mendes   +3 more
doaj   +1 more source

Let-7b microRNA and Sirtuin-1 mRNA gene expression as potential biomarkers for breast cancer Egyptian patients [PDF]

Ain Shams Medical Journal, 2023
Background and objectivesThe most frequently detected life-threatening malignancy in women is breast cancer. We aimed to evaluate Sirtuin-1 mRNA and let-7b microRNA gene expression in breast cancer patients in Egypt and to relate them with ...
Moatez Kamel, Doaa Gharib, Galal Ghaly, Mohamed Elhelbawy, Hadeel Shalaby, Amany Wahb   +5 more
doaj   +2 more sources

p53/sirtuin 1/NF-κB Signaling Axis in Chronic Inflammation and Maladaptive Kidney Repair After Cisplatin Nephrotoxicity

Frontiers in Immunology, 2022
Chronic inflammation contributes to maladaptive kidney repair, but its regulation is unclear. Here, we report that sirtuin 1 (SIRT1) is downregulated after repeated low-dose cisplatin (RLDC) injury, and this downregulation leads to p65 acetylation and ...
Ying Fu, Ying Wang, Yuxue Liu, Chengyuan Tang, Jiong Cai, Guochun Chen, Zheng Dong   +6 more
semanticscholar   +1 more source

Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBP α-miRNA-223 axis

Hepatology, 2021
Aging exacerbates liver neutrophil infiltration and alcohol‐associated liver disease (ALD) in mice and humans, but the underlying mechanisms remain obscure. This study aimed to examine the effect of aging and alcohol consumption on neutrophilic Sirtuin 1
Ruixue Ren, Yong He, D. Ding, Aoyuan Cui, Huarui Bao, Jing Ma, Xin Hou, Yu Li, D. Feng, Xiaoling Li, S. Liangpunsakul, Bin Gao, Hua Wang   +12 more
semanticscholar   +1 more source

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

Cancer Communications, 2022
Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial fission has been observed in several types of cancer.
Dan Wu, Yi Yang, Yiran Hou, Zifeng Zhao, Ning Liang, P. Yuan, Tao Yang, J. Xing, Jibin Li   +8 more
semanticscholar   +1 more source

Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma

Journal of International Medical Research, 2020
Objectives A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with ...
Hongzeng Wu, Qianqian Zhang, Yi Zhao, Fengzhou Xu, Jinming Zhang, Hongyan He, Xu Wang, Helin Feng   +7 more
doaj   +1 more source

Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling

Balkan Medical Journal, 2020
Background: Brain metastasis is a major cause of cancer death in patients with lung cancer. Sirtuin 1 and hsa-miR-217 have been identified to mediate the development of non-small cell lung cancer.
Wenxia Jiang, Likun Hou, Juan Wei, Yifeng Du, Yan Zhao, Xue Deng, Xiangdong Lin   +6 more
doaj   +1 more source