Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis [PDF]
iScienceSummary: Lysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation.
Runhua Du +13 more
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Sirtuin 1: A Dilemma in Transplantation [PDF]
Journal of Transplantation, 2020 Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Sara Assadiasl +4 more
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Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1
Frontiers in Endocrinology, 2022 The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality.
Jiayi Yan +3 more
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Renal Protective Effect of Sirtuin 1 [PDF]
Journal of Diabetes Research, 2014 Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD+-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied.
Yi-jun Dong +7 more
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Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2′-deoxyguanosine levels in healthy smokers: A case–control study [PDF]
Journal of International Medical ResearchObjectives This case–control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine in healthy ...
Samar Sultan
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Sirtuin 1 Levels in Recurrent Implantation Failure [PDF]
Revista Brasileira de Ginecologia e Obstetrícia, 2017 Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF).
Yaprak Engin-Ustun +8 more
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SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling [PDF]
Scientific ReportsImpaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear.
Mi Kyoung Seo +7 more
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Role of sirtuin-1 in diabetic nephropathy [PDF]
Journal of Molecular Medicine, 2019 Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed, the management of DN remains challenging.
Weixia Sun, Chaosheng Lu, Lu Cai
exaly +3 more sources
Sirtuin 1 in Host Defense during Infection
Cells, 2022 Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of
Jin Kyung Kim +2 more
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Low sirtuin-1 levels are linked to erythropoietin resistance in hemodialysis patients [PDF]
Renal FailureIntroduction Erythropoiesis-stimulating agents (ESAs) are widely used to manage anemia in chronic hemodialysis patients. However, some individuals exhibit ESA resistance, and its underlying mechanisms remain unclear. Sirtuin-1 (SIRT1), a key regulator of
Ebru Hekimgil, Cuma Bulent Gul
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