Results 21 to 30 of about 29,404,625 (274)

Sleep, Sirtuin 1 and Alzheimer’s disease: A review

Aging Brain, 2022
Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer’s disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded
Mehrane Mehramiz, Tenielle Porter, Simon M. Laws, Stephanie R. Rainey-Smith   +3 more
doaj   +4 more sources

Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1

Renal Failure, 2019
Background: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there is an urgent need to identify therapeutic targets to control the progression of cardiovascular disease.
Yingjie Liu, Yiru Wu, Zongli Diao, Weikang Guo, Wenhu Liu   +4 more
doaj   +2 more sources

Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients

Arquivos Brasileiros de Cardiologia, 2019
Background: Sirtuins may act in many cellular processes like apoptosis, DNA repair and lipid/glucose metabolism. Experimental studies suggested some sirtuin types may have protective effects against endothelial dysfunction, atherosclerosis, cardiac ...
Emrullah Kızıltunç, Arzu Kösem, Can Özkan, Burcu Uğurlu Ilgın, Harun Kundi, Mustafa Çetin, Ender Ornek   +6 more
doaj   +2 more sources

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

Biomedicines, 2021
The signaling pathways involved in age-related inflammation are increasingly recognized as targets for the development of preventive and therapeutic strategies.
Cátia Sousa, Bruno Miguel Neves, Alcino Jorge Leitão, Alexandrina Ferreira Mendes   +3 more
doaj   +1 more source

(+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter type 4 (GLUT-4) of (+)-catechin & proanthocyanidin fraction Uncaria ...
Silvy Arundita, Friardi Ismed, Rauza Sukma Rita, Deddi Prima Putra   +3 more
doaj   +1 more source

Sirtuin 1 in Host Defense during Infection

Cells, 2022
Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of
Jin Kyung Kim, Prashanta Silwal, Eun-Kyeong Jo   +2 more
doaj   +1 more source

Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma

Journal of International Medical Research, 2020
Objectives A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with ...
Hongzeng Wu, Qianqian Zhang, Yi Zhao, Fengzhou Xu, Jinming Zhang, Hongyan He, Xu Wang, Helin Feng   +7 more
doaj   +1 more source

Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling

Balkan Medical Journal, 2020
Background: Brain metastasis is a major cause of cancer death in patients with lung cancer. Sirtuin 1 and hsa-miR-217 have been identified to mediate the development of non-small cell lung cancer.
Wenxia Jiang, Likun Hou, Juan Wei, Yifeng Du, Yan Zhao, Xue Deng, Xiangdong Lin   +6 more
doaj   +1 more source

Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]

, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L, Sonia Lain, Major, LL, Zubriene, Asta, Lebl, T, Matulis, Daumantas, Lisa Pirrie, Morkunaite, Vaida, Tomas Lebl, McCarthy, Anna R., Asta Zubrienė, Louise L. Major, Matulis, D, Lain, Sonia, Daumantas Matulis, Morkunaite, V, Nicholas J. Westwood, Vaida Morkūnaitė, Major, Louise L., Westwood, NJ, Anna R. McCarthy, McCarthy, AR, Zubriene, A, Lebl, Tomas, Lain, S, Westwood, Nicholas J., Pirrie, Lisa   +26 more
core   +1 more source

The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test.
Ulker Tunca, Mustafa Saygin, Ozlem Ozmen, Rahime Aslankoc, Arzu Yalcin   +4 more
doaj   +1 more source