Results 41 to 50 of about 29,404,625 (274)

Decreased Serum Sirtuin-1 in COPD [PDF]

Chest, 2017
The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band ...
Yanagisawa, S, Papaioannou, AI, Papaporfyriou, A, Baker, JR, Vuppusetty, C, Loukides, S, Barnes, PJ, Ito, K   +7 more
openaire   +4 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

The Versatility of Sirtuin-1 in Endocrinology and Immunology [PDF]

Frontiers in Cell and Developmental Biology, 2020
Sirtuins belong to the class III family of NAD-dependent histone deacetylases (HDAC) and are involved in diverse physiological processes that range from regulation of metabolism and endocrine function to coordination of immunity and cellular responses to stress.
Fahmida Rasha, Brianyell McDaniel Mims, Isabel Castro-Piedras, Betsy J. Barnes, Betsy J. Barnes, Matthew B. Grisham, Rakhshanda Layeequr Rahman, Kevin Pruitt   +7 more
openaire   +3 more sources

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease

Clinical Interventions in Aging, 2021
Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Bielach-Bazyluk A, Zbroch E, Czajkowska K, Koc-Zorawska E, Kakareko K, Rydzewska-Rosolowska A, Hryszko T   +6 more
doaj  

Sirtuin 1 in lipid metabolism and obesity [PDF]

Annals of Medicine, 2011
Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor that directly links environmental nutrient signals to animal metabolic homeostasis. SIRT1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and ...
Thaddeus T, Schug, Xiaoling, Li
openaire   +2 more sources

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [PDF]

, 2008
We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna, Murray, Karen E., Stark, Michael J.R., Lain, Sonia, Stark, Michael J. R., Baker, Lee, Appleyard, Virgina, Higgins, Maureen, Pass, Georgia, Mathers, Joanne, Lane, David P., Staples, Oliver D., Woods, Julie, McCarthy, Anna, Holland, Stephen J., Hollick, Jonathan J., Aoubala, Mustapha, Thompson, Alastair, Westwood, Nicholas J., Appleyard, Virginia   +19 more
core   +1 more source

Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1

Frontiers in Pharmacology, 2022
Objective: One mechanism of hypothyroidism involves the disruption of thyroid hormone synthesis and secretion by thyrocytes. Hydrogen sulfide (H2S), as a gas signaling molecule, participates in many physiopathologic processes by upregulating sirtuin-1 ...
Xue Zhao, Yedi Cao, Hongfang Jin, Xiuli Wang, Lanbo Zhang, Yang Zhang, Yang Yu, Youyuan Huang, Ying Gao, Junqing Zhang   +9 more
doaj   +1 more source

Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period

, 2021
Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life.
Kristina Hase, Laura Stahmer, Anibh Martin Das, Hadeel Shammas, Corinna Peter, Bettina Bohnhorst   +5 more
core   +1 more source

Sirtuin 1 (SIRT1): The Misunderstood HDAC [PDF]

SLAS Discovery, 2011
The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven mammalian proteins, SIRT1-7. Many of the sirtuin isoforms also deacetylate nonhistone substrates, such as p53 (SIRT1) and α-tubulin (SIRT2). The sirtuin literature focuses on pharmacological activators of SIRT1 (e.g., resveratrol, SRT1720), proposed as therapeutics for ...
Walter, Stünkel, Robert M, Campbell
openaire   +2 more sources