Results 51 to 60 of about 29,404,625 (274)

The Role of Sirtuin 1 (SIRT1) in Neurodegeneration

Cureus, 2023
Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic pathways and play a role in several disease processes. Of the seven mammalian homologs currently identified, sirtuin 1 (SIRT1) is the best understood and most studied. It has been associated with several neurodegenerative diseases and cancers.
Razick, Daniel I, Akhtar, Muzammil, Wen, Jimmy, Alam, Meraj, Dean, Nabeal, Karabala, Muhammad, Ansari, Ubaid, Ansari, Zaid, Tabaie, Ethan, Siddiqui, Shakeel   +9 more
openaire   +2 more sources

Induced Pluripotent Stem Cells derived CD71^＋CD235a^＋ Erythroblasts Were Increased by Sirtuin 1 Activator. [PDF]

Int J Stem Cells
Induced pluripotent stem cells (iPSCs) are a promising cell source for regenerative medicine. Clinical applications require a large number of functional red blood cells (RBCs), making it essential to ensure the proliferation of actively dividing ...
Kim C, Park KH, Jeon SB, Han AR, Lee JY, Yoon YS.   +5 more
europepmc   +2 more sources

The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas [PDF]

Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and
Nagehan Barisik Ozdemir, Cem Cahit Barisik, Fatma Cakmak Kazanci, Sibel Sensu   +3 more
core   +1 more source

Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer [PDF]

, 2022
Penyakit Alzheimer merupakan penyakit neurodegeneratif bertahap dan progresif yang disebabkan oleh kematian sel saraf. Sampai saat ini belum ditemukan terapi yang bisa menyembuhkan penyakit Alzheimer, karena penyebabnya yang multifaktorial, sehingga ...
Havina, Nurul Aizah
core   +1 more source

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

Nature Communications, 2017
The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-
Guang Yang, Xinyu Weng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, Peng Wang, LeiLei Ma, Xiaolei Sun, Lei Hou, Huihui Xu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu, Aijun Sun   +16 more
doaj   +1 more source

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

Frontiers in Physiology, 2021
Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions.
Stefano Ministrini, Stefano Ministrini, Yustina M. Puspitasari, Georgia Beer, Luca Liberale, Luca Liberale, Fabrizio Montecucco, Fabrizio Montecucco, Giovanni G. Camici, Giovanni G. Camici, Giovanni G. Camici   +10 more
doaj   +1 more source

Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3 [PDF]

, 2012
Nonalcoholic steatosis is an important hepatic complication of obesity linked to mitochondrial dysfunction and oxidative stress. Lipoic acid (LA) has been reported to have beneficial effects on mitochondrial function and to attenuate oxidative stress ...
Martínez, Jose A. [0000-0001-5218-6941], González-Muniesa, Pedro, González-Muniesa, Pedro [0000-0002-3130-2496], Prieto-Hontoria, Pedro L., Pérez-Matute, Patricia, Valdecantos, M. Pilar, Valdecantos, María Pilar, Pérez-Matute, Patricia [0000-0003-2232-7971], Moreno-Aliaga, Maria J., Moreno-Aliaga, Maria J. [0000-0002-2018-6434], Martínez, José A.   +10 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source