Results 71 to 80 of about 29,404,625 (274)

Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism.

, 2012
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes.
Banks, A.S., Horvath, T.L., Dietrich, M.O., Pfluger, P.T., Tschöp, M.H., Nogueiras, R., Chaudhary, N., Sinclair, D.A., Habegger, K.M., Finan, B.   +9 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Sirtuin 1 as a key player of ‘metabolic memory’ [PDF]

Journal of Diabetes Investigation, 2012
The term, ‘metabolic memory’, was first advocated by the authors of the Diabetes Control and Complications Trial/Epidemiology of the Diabetes Interventions and Complications Study (DCCT/EDIC) and is well known for the benefits of achieving tight glycemic control on the progression of macrovascular events in diabetic patients in the early stage of ...
Hashiramoto, Mitsuru, Kaku, Kohei
openaire   +2 more sources

Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis

Autoimmunity, 2023
Introduction: To explore the value of serum sirtuin-1 (SIRT1) in the diagnosis and evaluation of joint mobility of rheumatoid arthritis (RA). Materials and Methods: Serum was randomly obtained from 212 RA patients,210 non-RA patients and 58 healthy ...
Liming Tan, Tanglin Ouyang, Xu Li, Yinyi Chen, Shipeng Ke, Jiayuan Chen, Ye Liu, Fajun Zeng, Yingxing Chen, Jing Long, Qingyue Deng, Xiaoyan Hu   +11 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Bisphenol A instigates diminished sirtuin-1 mediated vascular complications in type 2 diabetes mellitus [PDF]

Journal of Nephropharmacology
Endocrine society has evidence that plastics can disrupt the endocrine system to cause severe diseases in humans and animals. However, plastics are still used in a variety of models for their applications.
Mohanraj Nehru, Prasanth Subramanian, Vinothkumar Ganesan, Rajiv Janardhanan, Venkataraman Prabhu   +4 more
doaj   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Sirtuin-1 level and gene polymorphisms in multiple sclerosis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Sirtuin-1 (SIRT1) may affect multiple sclerosis (MS) disease. This study aimed to investigate the level of serum SIRT1, mRNA expression and genetic polymorphisms in Egyptian MS sufferers.
Rania S. Nageeb, Amal Fawzy, Marwa Abdel-Monem Ateya, Aliaa Talaat   +3 more
doaj   +1 more source

Sirtuin 1 and Hormonal Regulations in Aging

Applied Sciences
Aging affects the structure and functions of all organs and systems in the organism. In the elderly, significant changes in hormonal levels are observed.
Milena Keremidarska-Markova, Iliyana Sazdova, Mitko Mladenov, Bissera Pilicheva, Plamen Zagorchev, Hristo Gagov   +5 more
doaj   +1 more source

The Effect of Aerobic Training on Metabolic Parameters and Serum Level of Sirtuin1 in Women with Type 2 Diabetes [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016
Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes.
Abbas Saremi, Shahnaz Shahrjerdi, Atefe Kavyani   +2 more
doaj