Results 91 to 100 of about 29,404,625 (274)
Serum Sirtuin-1 Level in Rheumatoid Arthritis and its Relation to Disease Activity and Metabolic Syndrome [PDF]
Zagazig University Medical JournalBackground: Sirtuin-1 is a regulatory protein involved in inflammation, metabolism, and its role in rheumatoid arthritis activity and atherosclerosis remains under investigation. This research aimed to evaluate serum Sirtuin-1 levels in cases with RA and
Asmaa Wafa +5 more
doaj +1 more source
The influence of circadian variables on ecotoxicology metabolomics
Biological Reviews, EarlyView.ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester +3 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
, 2009 Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms.
Gutierrez-Cuesta, J. +9 more
core +1 more source
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Saccharomyces boulardii Mitigates Fructose-Induced Non-Alcoholic Fatty Liver in Rats
MedicinaBackground and Objectives: Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern closely linked to metabolic disorders, including obesity, insulin resistance, and dyslipidemia.
Mehmet Ulusan +4 more
doaj +1 more source
Endocrinology Research and Practice, 2023 Objective: The aim of this study is to investigate the length of telomere and serum silent information regulator-1 levels in type 2 diabetic subjects as well as their associations with body composition, glycemic control, and diabetic complications ...
Nazmi Gökhan Ünver +6 more
doaj
, 2020 A review of the literature indicated that sirtuin-1 expression, a regulator of nitric oxide bioavailability in erectile dysfunction (ED) after melatonin therapy, has not yet been investigated.
ŞEKERCİ, ÇAĞRI AKIN +3 more
core +1 more source
Exploration, EarlyView.Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li +23 more
wiley +1 more source