Results 81 to 90 of about 44,793 (241)
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients
Arquivos Brasileiros de CardiologiaBackground: Sirtuins may act in many cellular processes like apoptosis, DNA repair and lipid/glucose metabolism. Experimental studies suggested some sirtuin types may have protective effects against endothelial dysfunction, atherosclerosis, cardiac ...
Emrullah Kızıltunç +6 more
doaj +1 more source
In silico approach in the development of structural analogues of resveratrol with improved distribution in the central nervous system [PDF]
Kragujevac Journal of ScienceResveratrol exerts neuroprotective effects that are not only due to anti inflammatory and antioxidant activity but also by launched biogenesis via sirtuin-1 (SIRT1) protein that protects cells from oxidative stress.
Mitrović Darko, Pavlović Nebojša
doaj +1 more source
Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, EarlyView.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source
Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium
iMeta, EarlyView.Bazi Bushen Capsule (BZBS) mitigates age‐related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin−mediated mitophagy and Drp1 inhibition, improving endometrial function and fertility potential.
Shangqi Li +13 more
wiley +1 more source
World Journal of Traditional Chinese MedicineObjective: NOD-like receptor protein 3 (NLRP3)-mediated pyroptosis is pivotal in the pathological development of cerebral ischemia/reperfusion injury (CIRI).
Ya-Nan Luo +5 more
doaj +1 more source
Frontiers in Immunology, 2018 High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin).
Rob J. W. Arts +8 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue
iNew Medicine, EarlyView.ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao +3 more
wiley +1 more source
Bisphenol A instigates diminished sirtuin-1 mediated vascular complications in type 2 diabetes mellitus [PDF]
Journal of NephropharmacologyEndocrine society has evidence that plastics can disrupt the endocrine system to cause severe diseases in humans and animals. However, plastics are still used in a variety of models for their applications.
Mohanraj Nehru +4 more
doaj +1 more source