Results 31 to 40 of about 44,793 (241)
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Decreased Serum Sirtuin-1 in COPD [PDF]
Chest, 2017 The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band ...
Yanagisawa, S +7 more
openaire +4 more sources
The Versatility of Sirtuin-1 in Endocrinology and Immunology [PDF]
Frontiers in Cell and Developmental Biology, 2020 Sirtuins belong to the class III family of NAD-dependent histone deacetylases (HDAC) and are involved in diverse physiological processes that range from regulation of metabolism and endocrine function to coordination of immunity and cellular responses to stress.
Fahmida Rasha +7 more
openaire +3 more sources
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1 [PDF]
Experimental & Molecular Medicine, 2021 AbstractSirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is known about the regulation of SIRT1 activity. Here, we show that phospholipase D2 (PLD2), but not PLD1, selectively interacts with SIRT1 and increases the deacetylase activity of SIRT1.
Lee, Hyesung +5 more
openaire +2 more sources
Clinical Interventions in Aging, 2021 Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Bielach-Bazyluk A +6 more
doaj
Sirtuin 1 (SIRT1): The Misunderstood HDAC [PDF]
SLAS Discovery, 2011 The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven mammalian proteins, SIRT1-7. Many of the sirtuin isoforms also deacetylate nonhistone substrates, such as p53 (SIRT1) and α-tubulin (SIRT2). The sirtuin literature focuses on pharmacological activators of SIRT1 (e.g., resveratrol, SRT1720), proposed as therapeutics for ...
Walter, Stünkel, Robert M, Campbell
openaire +2 more sources
Medicina, 2023 Background and objectives: Cyclophosphamide (CPA) is an alkylating agent that is used for the management of various types of malignancies and as an immunosuppressive agent for the treatment of immunological disorders.
Mohamed F. Balaha +5 more
doaj +1 more source
Sirtuin 1 in lipid metabolism and obesity [PDF]
Annals of Medicine, 2011 Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor that directly links environmental nutrient signals to animal metabolic homeostasis. SIRT1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and ...
Thaddeus T, Schug, Xiaoling, Li
openaire +2 more sources
Journal of Research in Medical Sciences, 2021 Background: Visfatin is an adipokine that increased under inflammatory conditions. Moreover, sirtuin-1 possesses regulatory effects on inflammatory factors. In this study, we aimed to evaluate the serum level of visfatin in patients with stable and acute
Hassan Ghobadi +2 more
doaj +1 more source
Jurnal Kimia Sains dan Aplikasi, 2022 Cancer is a disease that starts from the uncontrolled growth of abnormal cells in the organs or tissues of the body, which is the second leading cause of death in the world.
Ruswanto Ruswanto +2 more
doaj +1 more source