Sleep, Sirtuin 1 and Alzheimer’s disease: A review
Aging Brain, 2022 Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer’s disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded
Mehrane Mehramiz +3 more
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function [PDF]
Current Issues in Molecular BiologyThe sirtuin-1 (SIRT1) gene contains multiple exons that usually undergo alternative splicing. The exclusion of one or more exons causes domain loss in the alternatively spliced isoforms and may change their functions.
Pankaj Patyal +8 more
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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD [PDF]
Frontiers in EndocrinologyIntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation.
Yao Xu +11 more
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Sirtuin 1 and endothelial glycocalyx [PDF]
Pflügers Archiv - European Journal of Physiology, 2020 AbstractSirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of ...
Lipphardt, Mark +5 more
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Neural Regeneration Research, 2021 In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang +5 more
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The long-term effect of moderate-intensity exercise on the expression of the genes irisin and sirtuin-1 in the skeletal muscle of diabetic rats with streptozotocin [PDF]
Journal of Exercise & Organ Cross Talk, 2022 Disorders of glucose metabolism in various tissues, including skeletal muscle tissue and adipose tissue are features of diabetes. The aim of the present study was to evaluate the long-term effect of moderate-intensity continuous exercise on the ...
Alireza Mohammadi, Mania Roozbayani
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Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
Exploration of Medicine, 2020 Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways.
Fatiha Nassir
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(+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter type 4 (GLUT-4) of (+)-catechin & proanthocyanidin fraction Uncaria ...
Silvy Arundita +3 more
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Biomedicines, 2021 The signaling pathways involved in age-related inflammation are increasingly recognized as targets for the development of preventive and therapeutic strategies.
Cátia Sousa +3 more
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The effect of 8 weeks of vitamin D supplementation and aerobic exercise on sirtuin-1 protein levels and oxidative stress markers of myocardial tissue in middle-aged male rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: Exercise training and vitamin D supplementation play an important role in cardiovascular health. However, the effects of combining these two strategies and their molecular role in cardiac adaptations are less known. Therefore, the
Sanaz Habibvand +2 more
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