Results 11 to 20 of about 29,404,625 (274)

Sirtuin 1: A Dilemma in Transplantation [PDF]

Journal of Transplantation, 2020
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar   +4 more
doaj   +5 more sources

Sirtuin 1 Levels in Recurrent Implantation Failure [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2017
Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF).
Yaprak Engin-Ustun, A. Seval Ozgu-Erdinc, Emel Kiyak Caglayan, Cavidan Gulerman, Esma Sarikaya, Ayla Aktulay, Canan Demirtas, Salim Erkaya, Nafiye Yilmaz   +8 more
doaj   +9 more sources

Sirtuin 1 and endothelial glycocalyx [PDF]

Pflügers Archiv - European Journal of Physiology, 2023
Sirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases.
Song, Jong Wook, Song, Jong Wook; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea, Goligorsky, Michael S, Lipphardt, Mark; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany, Lipphardt, Mark, Goligorsky, Michael S; Renal Research Institute, New York Medical College at the Touro University, Valhalla, USA   +5 more
core   +8 more sources

Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer [PDF]

Jurnal Kesehatan Andalas, 2023
Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation.
Havina Nurul Aizah, Amel Yanis, Hirowati Ali, Tofrizal Tofrizal, Cimi Ilmiawati, Dessy Arisanty   +5 more
doaj   +4 more sources

Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition.

PLoS ONE, 2014
Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death.
Cindy Gueguen, Bruno Palmier, Michel Plotkine, Catherine Marchand-Leroux, Valérie C Besson   +4 more
doaj   +2 more sources

Renal Protective Effect of Sirtuin 1 [PDF]

Journal of Diabetes Research, 2014
Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD+-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied.
Yi-jun Dong, Nian Liu, Zhi Xiao, Tao Sun, Shu-hui Wu, Wei-xia Sun, Zhong-gao Xu, Hang Yuan   +7 more
doaj   +3 more sources

Role of Sirtuin 1 in metabolic regulation

Drug Discovery Today, 2010
Sirtuin proteins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species. Recent
Silva, Jose P, Claes Wahlestedt, Wahlestedt, Claes, Jose P. Silva   +3 more
core   +3 more sources

Sirtuin-1 regulation of mammalian metabolism [PDF]

Trends in Molecular Medicine, 2011
Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization.
Derek M. Erion, Gerald I. Shulman, Shulman, Gerald I., Erion, Derek M., Gillum, Matthew P., Matthew P. Gillum   +5 more
core   +3 more sources

Sirtuin 1 Deacetylase [PDF]

, 2013
Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease ...
Kim, DH, Choi, SE, Dong Hyun Kim, Kemper, JK, Jongsook Kim Kemper, Sung-E. Choi   +5 more
core   +2 more sources

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

mBio, 2019
Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral
Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry   +8 more
doaj   +2 more sources