Results 51 to 60 of about 27,568,409 (275)

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease

Clinical Interventions in Aging, 2021
Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Bielach-Bazyluk A, Zbroch E, Czajkowska K, Koc-Zorawska E, Kakareko K, Rydzewska-Rosolowska A, Hryszko T   +6 more
doaj  

The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a potentially fatal multisystem inflammatory chronic disorder, the etiology and pathogenesis of which remain unclear.
Y. Qiu, Xingyu Zhou, Yu Liu, Siqi Tan, Yaping Li   +4 more
semanticscholar   +1 more source

Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA

Frontiers in Cellular Neuroscience, 2021
The N6-methyladenosine (m6A) modification is the most abundant posttranscriptional mRNA modification in mammalian cells and is dynamically modulated by a series of “writers,” “erasers,” and “readers.” Studies have shown that m6A affects RNA metabolism in
Hongxiu Zhou, Zongren Xu, Xingyun Liao, Shi-guo Tang, Na Li, Shengping Hou   +5 more
semanticscholar   +1 more source

Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus

Frontiers in Endocrinology, 2021
Diabetes mellitus (DM) has been one of the largest health concerns of the 21st century due to the serious complications associated with the disease. Therefore, it is essential to investigate the pathogenesis of DM and develop novel strategies to reduce ...
Jie Wang(a), Shudong Wang, Jie Wang(b), Mengjie Xiao, Yuanfang Guo, Yufeng Tang, Jingjing Zhang, J. Gu   +7 more
semanticscholar   +1 more source

Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury

Journal of Cellular and Molecular Medicine, 2021
Sirtuin 1 (SIRT1) plays a very important role in a wide range of biological responses, such as metabolism, inflammation and cell apoptosis. Changes in the levels of SIRT1 have been detected in the brain after traumatic brain injury (TBI).
Guan Wei, Jiawei Wang, Yanbing Wu, Xiaoxin Zheng, Yile Zeng, Yasong Li, Xiangrong Chen   +6 more
semanticscholar   +1 more source

Effects of sirtuin 1 deficiency on trophoblasts and its implications in the pathogenesis of pre-eclampsia

Journal of Obstetrics and Gynaecology, 2023
Background Sirtuin 1 (SIRT1) is mainly localised in syncytiotrophoblasts and cytotrophoblasts, and is involved in pregnancy regulation. However, data on the association between SIRT1 and pre-eclampsia (PE) remains limited. This study aimed to investigate
Hongbiao Yu, Ling Chen, Ping Du, Xianping Liu, Ying Xia   +4 more
doaj   +1 more source

Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway

Viruses, 2021
Dengue virus (DENV) is the causative pathogen in the life-threatening dengue hemorrhagic fever and dengue shock syndrome. DENV is transmitted to humans via the bite of an infected Aedes mosquito.
Atthapan Morchang, Shilu Malakar, Kanchanaphan Poonudom, S. Noisakran, P. Yenchitsomanus, T. Limjindaporn   +5 more
semanticscholar   +1 more source

The role of sirtuin 1 on the induction of trained immunity.

Cellular Immunology, 2021
Sirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate of trained immunity, a de facto innate immune memory, we investigated the role of SIRT1 in ...
V. Mourits, Leonie S Helder, V. Matzaraki, V. Koeken, L. Groh, L. D. de Bree, S. Moorlag, C. V. D. van der Heijden, S. Keating, Jelmer H. van Puffelen, M. Jaeger, L. Joosten, M. Netea   +12 more
semanticscholar   +1 more source

Predictors of Survival Among the Oldest Old Following Acute Hospital Admission: Insights From Clinical and Biochemical Factors

Gerontology and Geriatric Medicine, 2023
Understanding the factors influencing survival in oldest old population is crucial for providing appropriate care and improving outcomes. This prospective observational study aimed to investigate the determinants of survival in acutely ill oldest old ...
Bhawana Painkra MD, Masroor Anwar PhD, Abhinay Kumar Singh Msc, Vishwajeet Singh PhD, Abhijith Rajaram Rao MD, Akshata Rao MD, Meenal Thakral MD, Avinash Chakrawarty MD, Prasun Chatterjee MD, Aparajit Ballav Dey MD   +9 more
doaj   +1 more source