Results 61 to 70 of about 27,568,409 (275)
Biomolecules, 2021 The loss of cardioprotection observed in premenopausal, diabetic women may result from the interplay between epigenetic, metabolic, and immunological factors.
M. Łukawska-Tatarczuk +8 more
semanticscholar +1 more source
Decreased Serum Sirtuin-1 in COPD [PDF]
Chest, 2017 The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band ...
Yanagisawa, S +7 more
openaire +4 more sources
The Versatility of Sirtuin-1 in Endocrinology and Immunology [PDF]
Frontiers in Cell and Developmental Biology, 2020 Sirtuins belong to the class III family of NAD-dependent histone deacetylases (HDAC) and are involved in diverse physiological processes that range from regulation of metabolism and endocrine function to coordination of immunity and cellular responses to stress.
Fahmida Rasha +7 more
openaire +3 more sources
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
Nature Communications, 2017 The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-
Guang Yang +16 more
doaj +1 more source
Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors
Circulation: Heart Failure, 2020 The cardioprotective effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors may be related to their ability to induce a fasting-like paradigm, which triggers the activation of nutrient deprivation pathways to promote cellular homeostasis.
M. Packer
semanticscholar +1 more source
Sirtuin 1 (SIRT1): The Misunderstood HDAC [PDF]
SLAS Discovery, 2011 The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven mammalian proteins, SIRT1-7. Many of the sirtuin isoforms also deacetylate nonhistone substrates, such as p53 (SIRT1) and α-tubulin (SIRT2). The sirtuin literature focuses on pharmacological activators of SIRT1 (e.g., resveratrol, SRT1720), proposed as therapeutics for ...
Walter, Stünkel, Robert M, Campbell
openaire +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
International Journal of Molecular Sciences, 2022 HSV-1 is a typical neurotropic virus that infects the brain and causes keratitis, cold sores, and occasionally, acute herpes simplex encephalitis (HSE).
Xiaowei Song +10 more
semanticscholar +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Sirtuin 1 in lipid metabolism and obesity [PDF]
Annals of Medicine, 2011 Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor that directly links environmental nutrient signals to animal metabolic homeostasis. SIRT1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and ...
Thaddeus T, Schug, Xiaoling, Li
openaire +2 more sources