Results 61 to 70 of about 29,404,575 (242)

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism.

, 2012
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes.
Banks, A.S., Horvath, T.L., Dietrich, M.O., Pfluger, P.T., Tschöp, M.H., Nogueiras, R., Chaudhary, N., Sinclair, D.A., Habegger, K.M., Finan, B.   +9 more
core   +1 more source

Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy

Journal of Diabetes Investigation, 2021
Aims/Introduction The shortening of leukocyte telomere length with age has been associated with coronary disease, whereas the association with type 1 diabetes is unclear.
Trine Baur Opstad, Tore Julsrud Berg, Kristine Bech Holte, Harald Arnesen, Svein Solheim, Ingebjørg Seljeflot   +5 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Sirtuin-1 level and gene polymorphisms in multiple sclerosis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Sirtuin-1 (SIRT1) may affect multiple sclerosis (MS) disease. This study aimed to investigate the level of serum SIRT1, mRNA expression and genetic polymorphisms in Egyptian MS sufferers.
Rania S. Nageeb, Amal Fawzy, Marwa Abdel-Monem Ateya, Aliaa Talaat   +3 more
doaj   +1 more source

Sirtuin 1 and Hormonal Regulations in Aging

Applied Sciences
Aging affects the structure and functions of all organs and systems in the organism. In the elderly, significant changes in hormonal levels are observed.
Milena Keremidarska-Markova, Iliyana Sazdova, Mitko Mladenov, Bissera Pilicheva, Plamen Zagorchev, Hristo Gagov   +5 more
doaj   +1 more source

The Effect of Aerobic Training on Metabolic Parameters and Serum Level of Sirtuin1 in Women with Type 2 Diabetes [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016
Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes.
Abbas Saremi, Shahnaz Shahrjerdi, Atefe Kavyani   +2 more
doaj  

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source