Results 81 to 90 of about 29,404,575 (242)
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
, 2009 Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms.
Gutierrez-Cuesta, J. +9 more
core +1 more source
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
, 2020 A review of the literature indicated that sirtuin-1 expression, a regulator of nitric oxide bioavailability in erectile dysfunction (ED) after melatonin therapy, has not yet been investigated.
ŞEKERCİ, ÇAĞRI AKIN +3 more
core +1 more source
Exploration, EarlyView.Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li +23 more
wiley +1 more source
Evaluation of serum levels of sirtuin-1 in lung cancer [PDF]
Background: Sirtuin-1 is a protein from the family of sirtuins that has been implicated in inflammaging and oxidative stress in cancer patients. Aim: The aim of this study was to investigate the serum level of Sirtuin-1 and its relation with quality ...
حسینی نیا, سعید +4 more
core
Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition [PDF]
, 2019 The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders ...
Nima, Rajabi +8 more
core +2 more sources
Sirtuin-1 Signaling Regulates Organismal Growth by Altering Feeding Behavior and Stem Cell Differentiation in Planarians. [PDF]
, 2019 Food consumption leads to an increase in body size in the planarian model Schmidtea mediterranea. How food consumption integrates with cell division at the organismal level remains unclear.
Ziman, Benjamin Matthew
core +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing +6 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto +9 more
wiley +1 more source