Results 101 to 110 of about 29,404,575 (242)

Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds

Drug Design, Development and Therapy
Yanli Wang,1 Yan Liu,1,2 Yongle Wang,1,3 Ping Bai,1 Madelyn Rose Hallisey,1 Breanna Lizeth Varela,1 Anne Siewko,1 Changning Wang,1 Yulong Xu1 1Athinoula A.
Wang Y, Liu Y, Wang Y, Bai P, Hallisey MR, Varela BL, Siewko A, Wang C, Xu Y   +8 more
doaj  

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Sirtuin 1 Deacetylase

, 2013
Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease ...
Kim, DH, Choi, SE, Dong Hyun Kim, Kemper, JK, Jongsook Kim Kemper, Sung-E. Choi   +5 more
core   +1 more source

Olaparib Blocks Oxidative Stress‐Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK‐Driven Autophagic Flux

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric acute lung injury (ALI) is a life‐threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo ...
Fen Gong, Mei‐Ling Yu, Zheng‐Rong Chen, Mei Li, Xu Sang, Yong‐Dong Yan   +5 more
wiley   +1 more source

KORELASI KADAR SIRTUIN-1 SERUM DENGAN KADAR TRANSFORMING GROWTH FACTOR-Β1 PADA PASIEN PENYAKIT GINJAL KRONIK [PDF]

Pendahuluan : Penyakit Ginjal Kronis (PGK) merupakan masalah kesehatan global dengan prevalensi yang terus meningkat dan tingkat mortalitas yang tinggi.
Retno, Eka Sari
core   +1 more source

The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice

Neural Regeneration Research
[INLINE:1] Studies have shown that C1q/tumor necrosis factor-related protein-6 (CTRP6) can alleviate renal ischemia/reperfusion injury in mice. However, its role in the brain remains poorly understood.
Bo Zhao, Mei Li, Bingyu Li, Yanan Li, Qianni Shen, Jiabao Hou, Yang Wu, Lijuan Gu, Wenwei Gao   +8 more
doaj   +1 more source

Correction: Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase Inhibition

, 2014
Correction: Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase ...
PLOS ONE (2189197)
core   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Parakuat ile oksidatif stres oluşturulan farelerde embriyo implantasyonunda sirtuin 1’in rolünün araştırılması

, 2019
Amaç: İmplantasyon embriyonun maternal uterusa yerleşme sürecidir. Zigotun blastosiste gelişmesi ve uterusun reseptif hale gelmesinin senkronize olması kritik öneme sahiptir. Sirtuinler, yüksek derecede korunmuş histon/protein deasetilazlardır. Sirtuin 1
Aksu, Kübra
core  

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

, 2013
Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational
Dahl Ejby Jensen, Lasse,, Montano, Sergio J,, Dreij, Kristian,, Poschmann, Gereon,, Uhlen, Per,, Brautigam, Lars,, Prozorovski, Timour,, Bannenberg, Sarah,, Lepka, Klaudia,, Holmgren, Arne,, Nystrom, Staffan,, Stuehler, Kai,, Aktas, Orhan,, Cao, Yihai,, Berndt, Carsten,   +14 more
core   +1 more source