Results 51 to 60 of about 72,220 (305)

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]

, 2013
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
Arturo Londono-Vallejo, Claudia Colussi (377816), Luis Jaime Castro-Vega (409816), Londono-Vallejo Arturo, Londono-Vallejo, Arturo, Simona Nanni, Colussi Claudia, Nanni, Simona, Pontecorvi, Alfredo, Castro-Vega, Luis Jaime, Carlo Gaetano (110837), Capogrossi, Maurizio C., Re, Agnese, Silvia Bacchetti (409817), Aiello Aurora, Valentina Benvenuti (409815), Guffanti Alessandro, Felsani, Armando, Claudia Colussi, Simona Nanni (110816), Maurizio C Capogrossi, Felsani Armando, Bacchetti, Silvia, Luis Jaime Castro-Vega, Benvenuti, Valentina, Armando Felsani (132772), Re Agnese, Pontecorvi Alfredo, Antonella Farsetti, Alessandro Guffanti, Gaetano, Carlo, Armando Felsani, Agnese Re, Castro-Vega Luis Jaime, Arturo Londono-Vallejo (5654743), Aurora Aiello, Nanni Simona, Alessandro Guffanti (5573), Maurizio C. Capogrossi (103525), Gaetano Carlo, Carlo Gaetano, Agnese Re (409814), Aurora Aiello (358824), Guffanti, Alessandro, Farsetti Antonella, Farsetti, Antonella, Capogrossi Maurizio C., Alfredo Pontecorvi, Alfredo Pontecorvi (409818), Antonella Farsetti (110827), Silvia Bacchetti, Aiello, Aurora, Benvenuti Valentina, Bacchetti Silvia, Colussi, Claudia, Valentina Benvenuti   +55 more
core   +1 more source

The Activity of Sirtuin 1 in MCF-7 Breast Cancer Cell Line: The Effects of Visfatin [PDF]

Journal of Advanced Biomedical Sciences, 2015
Background & Objectives: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Obesity, hormones, and growth factors are the risk factors for this kind of cancer.
kiarash behrouzfar, mitra nourbakhsh, mohammad alaiee   +2 more
doaj  

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

Tat-SIRT1 Tango [PDF]

Molecular Cell, 2008
In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
Blazek, Dalibor, Peterlin, B. Matija
openaire   +2 more sources

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases [PDF]

, 2020
Neurodegenerative disease refers to a range of chronic and progressive disorders that are characterized by dysfunction and loss of neurons. Neurodegeneration involves protein misfolding, oxidative injury, impaired mitochondrial function, neurotrophin ...
Zhang, Yuqing, Anoopkumar-Dukie, Shailendra, Arora, Devinder, Davey, Andrew K   +3 more
core   +1 more source

SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro [PDF]

, 2021
Neuroinflammation is associated with the development of depression. Deacetylases SIRT1 and SIRT2 are reported to exert neuroprotective effects in aging, neurogenesis, neurodegeneration and neuroinflammation. Therefore, this study aimed to investigate the
Mallik, SB, Zhang, Y, Anoopkumar-Dukie, S, Davey, AK   +3 more
core   +1 more source

SIRT1 and thrombosis

Frontiers in Molecular Biosciences
Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and ...
Bettiol, Alessandra, Urban, Maria Letizia, Emmi, Giacomo, Galora, Silvia, Argento, Flavia Rita, Fini, Eleonora, Borghi, Serena, Bagni, Giacomo, Mattioli, Irene, Prisco, Domenico, Fiorillo, Claudia, Becatti, Matteo   +11 more
openaire   +4 more sources

GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway

Diabetes, Metabolic Syndrome and Obesity, 2023
Jie Xiang,1 Liyan Qin,2 Jinling Zhong,3 Ning Xia,2 Yuzhen Liang3 1Department of Clinical Nutrition, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department of Geriatric Endocrinology, The First ...
Xiang J, Qin L, Zhong J, Xia N, Liang Y
doaj  

Sirt1 and the Mitochondria

Molecules and Cells, 2016
Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1α (PGC-1α) has been extensively implicated in ...
openaire   +3 more sources

Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss

Frontiers in Bioscience-Landmark
Background: It has been reported the therapeutic effects of mesenchymal stem cells (MSCs) on hearing loss. This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on
Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie   +4 more
doaj   +1 more source