Results 51 to 60 of about 102,380 (310)

Hypothalamic Sirt1 in aging

Aging, 2014
There is an old Japanese proverb saying, “After rain falls, the ground hardens.” This proverb illustrates what has happened to the research field on the importance of sirtuins in the regulation of aging and longevity. The Sir2 (silent information regulator 2) family of protein deacylases, now called sirtuins, have been shown to regulate aging and ...
Akiko, Satoh, Shin-ichiro, Imai
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss

Frontiers in Bioscience-Landmark
Background: It has been reported the therapeutic effects of mesenchymal stem cells (MSCs) on hearing loss. This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on
Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie   +4 more
doaj   +1 more source

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1 [PDF]

, 2013
BACKGROUND We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases.
A Filipovic, AA Adjei, AJ Levine, B Vogelstein, C-Y Koo, CH Shen, CL Brooks, D Zhang, DP Xirodimas, DR Rhodes, F De Amicis, F Vikhanskaya, G Giamas, G Giamas, H Mi, H Vaziri, H Zhang, H Zhang, HR Xing, J Cox, J Cox, J Hu, J Lozano, J Stebbing, J Yuan, JA Goettel, JE Kim, JR Wisniewski, K Kornfeld, L C Lit, L Zannini, M Therrien, M Therrien, M Zafrullah, MN Laurent, R Brough, R Fujita, R Kolesnick, RL Kortum, S Matsuoka, T Rajakulendran, TE Thingholm, V Nin, W Zhao, WM Abida, Y Tang, Y Xu, Y Zhang   +47 more
core   +2 more sources

SIRT1 Regulation Modulates Stroke Outcome [PDF]

Translational Stroke Research, 2013
Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue needs in a disturbed environment ...
Petegnief, Valérie, Planas, Anna M.
openaire   +3 more sources

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Alterations of clock gene RNA expression in brain Regions of a triple transgenic model of Alzheimer's Disease [PDF]

, 2017
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light ...
@corresponding, Author, Bellanti, Francesco, Blonda, Maria, Calcagnini, Silvio, Cassano, Tommaso, Gaetani, Silvana, Giudetti, Anna Maria, Iannelli, Giuseppina, Mazzoccoli, Gianluigi, Romano, Adele, Serviddio, Gaetano, Tamborra, Rosanna, Vendemiale, Gianluigi, Villani, Rosanna, Vinciguerra, Manlio   +14 more
core   +1 more source

Caloric restriction, SIRT1 and longevity [PDF]

Trends in Endocrinology & Metabolism, 2009
More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been ...
C. Canto, J. Auwerx.
openaire   +2 more sources

SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury [Retraction]

Journal of Inflammation Research, 2022
Wang D, Cao H, Wang X, et al. J Inflamm Res. 2021;14:1283-1296. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Wang D, Cao H, Wang X, Wang J, Wang M, Zhang J, Wang L   +6 more
doaj  

Antagonizing CD105 enhances radiation sensitivity in prostate cancer. [PDF]

, 2018
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery.
Andres, Allen, Angara, Bryan, Bhowmick, Neil A, Duong, Frank, Gottlieb, Roberta, Haldar, Subhash, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Zumsteg, Zachary S   +9 more
core   +1 more source