Results 51 to 60 of about 77,206 (307)
Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
Kevin B Koronowski +1 more
openaire +3 more sources
GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway
Diabetes, Metabolic Syndrome and Obesity, 2023 Jie Xiang,1 Liyan Qin,2 Jinling Zhong,3 Ning Xia,2 Yuzhen Liang3 1Department of Clinical Nutrition, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department of Geriatric Endocrinology, The First ...
Xiang J, Qin L, Zhong J, Xia N, Liang Y
doaj
Molecules and Cells, 2016 Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1α (PGC-1α) has been extensively implicated in ...
openaire +3 more sources
HEX ameliorates S. aureus-induced inflammation in MMECs through PPARα-SIRT1-NF-κB axis.
, 2023 A-F and H. GW6471 (25 μM) and HEX (5 μM) were performed for 2 h followed by S. aureus (105 CFU) treatment for the next 24 h. A. The relative intensities of PPARα was analyzed by western blotting (n = 5). B-D.
Lianjun Feng (11177968) +13 more
core +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Frontiers in Bioscience-LandmarkBackground: It has been reported the therapeutic effects of mesenchymal stem cells (MSCs) on hearing loss. This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on
Jiali Liu +4 more
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Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [PDF]
, 2008 We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna +19 more
core +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Journal of Inflammation Research, 2022 Wang D, Cao H, Wang X, et al. J Inflamm Res. 2021;14:1283-1296. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Wang D +6 more
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