SIRT1-ER mRNA and protein in sirt1+/ER and sirt1ER/ER tissues.
, 2017 A. Levels of mRNA from the sirt1ER gene are higher than those from sirt1+. RNA was isolated from brain, liver and testes of sirt1ER/ER and sirt1+/+ mice and used for quantitative assessment of SIRT1 mRNA levels by comparative PCR.
Annabelle Z. Caron (2692186) +7 more
core +1 more source
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. [PDF]
, 2016 Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be ...
Lisa Yi Liang +9 more
core +1 more source
SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression?
, 2021 Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy.
Shailendra Anoopkumar-Dukie +5 more
core +1 more source
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas [PDF]
, 2017 BACKGROUND: The most prevalent form of bone cancer is osteosarcoma (OS), which is associated with poor prognosis in case of metastases formation. Mice harbouring liver kinase B1 (LKB1(+/-)) develop osteoblastoma-like tumours.
Flanagan, AM +17 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
doaj +1 more source
SIRT1-MKO mice have mild dystrophic pathology.
, 2019 (a) Immunofluorescence staining for SIRT1 (ab110304, Abcam), dystrophin, caveolin 3 and nNOS in muscle sections from WT mice at 6 months of age. Cytoplasm of skeletal muscles was stained with phalloidin.
Rio Sebori (6883070) +6 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Melatonin attenuates fluoride-induced neurotoxicity and cognitive dysfunction through modulation of oxidative stress, neuroinflammation, and SIRT1 signaling in Wistar rats [PDF]
Veterinary WorldBackground and Aim: Chronic fluoride exposure causes neurotoxicity, oxidative stress, neuroinflammation, and cognitive impairment, posing a significant public health concern.
Newly Bagang +6 more
doaj +1 more source
Cells, 2020 Emerging evidence indicates that aberrant maternal inflammation is associated with several pregnancy-related disorders such as preeclampsia, preterm birth, and intrauterine growth restriction.
Sumi Park +7 more
doaj +1 more source