Results 61 to 70 of about 72,220 (305)
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [PDF]
, 2008 We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna +19 more
core +1 more source
SIRT1-mediated CRIF1 deletion-induced inflammatory cytokine and VCAM-1 expression. [PDF]
, 2018 (A) HUVECs were infected with β-Gal and SIRT1 adenovirus for 24 h, followed by transfection with CRIF1 (100 pmol) siRNA for 36 h. TNFα, IL-1β, and IL-6 mRNA levels were quantified using qPCR.
Byeong Hwa Jeon (573935) +17 more
core +1 more source
Journal of Inflammation Research, 2022 Wang D, Cao H, Wang X, et al. J Inflamm Res. 2021;14:1283-1296. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Wang D +6 more
doaj
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. [PDF]
, 2016 Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be ...
Lisa Yi Liang +9 more
core +1 more source
Computational evaluation of bioactive compounds in Curcuma zanthorrhiza targeting SIRT1 and NFκB [PDF]
, 2023 Type 2 diabetes mellitus (T2DM) is a metabolic disease with a high risk of complications and mortality. Novel T2DM therapeutic interventions are needed to combat this disease.
Atho'illah, Mochammad Fitri +7 more
core +1 more source
Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
Kevin B Koronowski +1 more
openaire +3 more sources
Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas [PDF]
, 2017 BACKGROUND: The most prevalent form of bone cancer is osteosarcoma (OS), which is associated with poor prognosis in case of metastases formation. Mice harbouring liver kinase B1 (LKB1(+/-)) develop osteoblastoma-like tumours.
Flanagan, AM +17 more
core +1 more source
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source