Results 41 to 50 of about 77,206 (307)

Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population

Indonesian Journal of Biotechnology, 2018
Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to prevent future risk of developing chronic diseases. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver
Eunice Limantara, Felicia Kartawidjajaputra, Antonius Suwanto   +2 more
doaj   +1 more source

Roles of SIRT1 in leukemogenesis [PDF]

Current Opinion in Hematology, 2013
This review provides a concise summary of significant research progress on SIRT1 deacetylase in leukemia in the past year. SIRT1 is a multifunctional protein and recent studies demonstrate that SIRT1 plays a crucial role in myeloid leukemogenesis and drug resistance.SIRT1 expression is typically low in normal adult hematopoietic stem/progenitor cells ...
WenYong, Chen, Ravi, Bhatia
openaire   +2 more sources

Design and Synthesis of Amino Acid Derivatives of Substituted Benzimidazoles and Pyrazoles as Selective Sirt1 Inhibitors [PDF]

, 2020
Owing to its presence in several biological processes Sirt1 served as a potential therapeutic target for many diseases. Here we report the synthesis of two distinct series of novel Sirt1 selective inhibitors, benzimidazole monopeptides and 5-pyrazolyl ...
Shailendra, Asthana, Bugga, Paramesha, Sanjay K, Banerjee, Boja, Poojary, Vasantha, Kumar, Mrityunjay, Singh, Nikil, Purushotham, Sharad, Wakode   +7 more
core   +1 more source

Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis

Frontiers in Bioscience-Landmark, 2023
Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring that, ultimately, affect lung ...
Iman Ramli, Thamere Cheriet, Anna Maria Posadino, Roberta Giordo, Hatem Zayed, Ali H. Eid, Gianfranco Pintus   +6 more
doaj   +1 more source

Evaluation of The Relationship among The Levels of SIRT1 and SIRT3 with Oxidative Stress and DNA Fragmentation in Asthenoteratozoospermic Men [PDF]

International Journal of Fertility and Sterility, 2021
Background: Reactive oxygen species (ROS) play a crucial role in etiology of DNA fragmentation and lipid peroxidationin sperm, leading to infertility in men.
Abolfazl Nasiri, Asad Vaisi-Raygani, Zohreh Rahimi, Mitra Bakhtiari, Fariborz Bahrehmand, Amir Kiani, Hadi Mozafari, Tayebeh Pourmotabbed   +7 more
doaj   +1 more source

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]

, 2013
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
Arturo Londono-Vallejo, Claudia Colussi (377816), Luis Jaime Castro-Vega (409816), Londono-Vallejo Arturo, Londono-Vallejo, Arturo, Simona Nanni, Colussi Claudia, Nanni, Simona, Pontecorvi, Alfredo, Castro-Vega, Luis Jaime, Carlo Gaetano (110837), Capogrossi, Maurizio C., Re, Agnese, Silvia Bacchetti (409817), Aiello Aurora, Valentina Benvenuti (409815), Guffanti Alessandro, Felsani, Armando, Claudia Colussi, Simona Nanni (110816), Maurizio C Capogrossi, Felsani Armando, Bacchetti, Silvia, Luis Jaime Castro-Vega, Benvenuti, Valentina, Armando Felsani (132772), Re Agnese, Pontecorvi Alfredo, Antonella Farsetti, Alessandro Guffanti, Gaetano, Carlo, Armando Felsani, Agnese Re, Castro-Vega Luis Jaime, Arturo Londono-Vallejo (5654743), Aurora Aiello, Nanni Simona, Alessandro Guffanti (5573), Maurizio C. Capogrossi (103525), Gaetano Carlo, Carlo Gaetano, Agnese Re (409814), Aurora Aiello (358824), Guffanti, Alessandro, Farsetti Antonella, Farsetti, Antonella, Capogrossi Maurizio C., Alfredo Pontecorvi, Alfredo Pontecorvi (409818), Antonella Farsetti (110827), Silvia Bacchetti, Aiello, Aurora, Benvenuti Valentina, Bacchetti Silvia, Colussi, Claudia, Valentina Benvenuti   +55 more
core   +2 more sources

Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury [PDF]

, 2023
Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose-dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing the patient's ...
Wang, Yueying, Zhou, Zandong, Tse, Gary, Xie, Bingxin, Zhang, Yue, King, Emma, Zhang, Q., Liu, Daiqi, Liu, T., Zhang, Y.   +9 more
core   +1 more source

The Activity of Sirtuin 1 in MCF-7 Breast Cancer Cell Line: The Effects of Visfatin [PDF]

Journal of Advanced Biomedical Sciences, 2015
Background & Objectives: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Obesity, hormones, and growth factors are the risk factors for this kind of cancer.
kiarash behrouzfar, mitra nourbakhsh, mohammad alaiee   +2 more
doaj  

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

SIRT1 and thrombosis

Frontiers in Molecular Biosciences
Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and ...
Bettiol, Alessandra, Urban, Maria Letizia, Emmi, Giacomo, Galora, Silvia, Argento, Flavia Rita, Fini, Eleonora, Borghi, Serena, Bagni, Giacomo, Mattioli, Irene, Prisco, Domenico, Fiorillo, Claudia, Becatti, Matteo   +11 more
openaire   +4 more sources