Results 21 to 30 of about 65,348 (268)
Neurogenesis directed by Sirt1 [PDF]
Nature Cell Biology, 2008 Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1.
Sergiy, Libert +2 more
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Malang Neurology Journal, 2022 Background: Neurodegenerative diseases are the main cause of morbidity and disability in the elderly. SIRT1 activation has been gaining popularity as novel treatment target. Cinnamon is known to possess neuroprotective abilities, however the mechanism in
Umi Kalsum +7 more
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AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator [PDF]
Molecular Cell, 2007 SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
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Journal of Applied Poultry Research, 2021 Summary: To explore the role of insulin and forkhead box protein O1 (FoxO1) on cell proliferation regulated by sirtuin 1 (Sirt1) in goose primary hepatocyte, goose primary hepatocytes were isolated and incubated with Sirt1 inhibitor and nicotinamide, and
Rongxue Wei +9 more
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Artesunate reduces sepsis-mediated acute lung injury in a SIRT1-dependent manner [PDF]
BioImpacts, 2023 Introduction: Sepsis-mediated acute lung injury (ALI) is a critical clinical condition. Artesunate (AS) is a sesquiterpene lactone endoperoxide that was discovered in Artemisia annua, which is a traditional Chinese herb.
Zhaohui Liu +4 more
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The Roles of SIRT1 in Cancer [PDF]
Genes & Cancer, 2013 The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in ...
Zhenghong, Lin, Deyu, Fang
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Indonesian Journal of Biotechnology, 2018 Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to prevent future risk of developing chronic diseases. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver
Eunice Limantara +2 more
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Roles of SIRT1 in leukemogenesis [PDF]
Current Opinion in Hematology, 2013 This review provides a concise summary of significant research progress on SIRT1 deacetylase in leukemia in the past year. SIRT1 is a multifunctional protein and recent studies demonstrate that SIRT1 plays a crucial role in myeloid leukemogenesis and drug resistance.SIRT1 expression is typically low in normal adult hematopoietic stem/progenitor cells ...
WenYong, Chen, Ravi, Bhatia
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Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis
Frontiers in Bioscience-Landmark, 2023 Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring that, ultimately, affect lung ...
Iman Ramli +6 more
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Evaluation of The Relationship among The Levels of SIRT1 and SIRT3 with Oxidative Stress and DNA Fragmentation in Asthenoteratozoospermic Men [PDF]
International Journal of Fertility and Sterility, 2021 Background: Reactive oxygen species (ROS) play a crucial role in etiology of DNA fragmentation and lipid peroxidationin sperm, leading to infertility in men.
Abolfazl Nasiri +7 more
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