Results 21 to 30 of about 72,220 (305)

Regulation of SIRT1 by MicroRNAs [PDF]

Molecules and Cells, 2013
Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to ...
Sung-E, Choi, Jongsook Kim, Kemper
openaire   +2 more sources

LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1

Autoimmunity, 2021
Background Recent studies have provided strong evidence that lncRNAs play a functional regulatory role in diabetic retinopathy (DR). The purpose of this study was to investigate the effect of long non-coding RNA (lncRNA) X-inactive specific transcript ...
Jiayu Zhang, Chengwei Chen, Sifang Zhang, Jiawei Chen, Liang Wu, Zhenguo Chen   +5 more
doaj   +1 more source

The Role of SIRT1 in Tumorigenesis [PDF]

American Chinese Journal of Medicine and Science, 2011
NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones.
Kai Li, Jianyuan Luo, Gissou Azabdaftari
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SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53 [PDF]

, 2010
Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-
Ahmed, Shafiq U., Milner, J, Jack Ford, Li, Han, Li, H, Ford, J, Serrano, M, Lynch, CJ, Milner, Jo, Ford Jack, Han Li, Blagosklonny, Mikhail V., Ahmed, Shafiq, Allison, SJ, Jo Milner, Simon J Allison, Simon J. Allison, Manuel Serrano, Warnock Lorna J., Warnock, LJ, Lorna J Warnock, Zahid H. Shah, Shafiq U Ahmed, Lorna J. Warnock, Serrano, Manuel, Shah, ZH, Lynch Cian J., Shah, Zahid H., Allison, Simon J., Shah Zahid H., Shafiq U. Ahmed, Serrano Manuel, Milner Jo, Cian J. Lynch, Lynch, Cian J., Li Han, Ahmed Shafiq U., Allison Simon J., Ford, Jack, Warnock, Lorna J., Cian J Lynch, Zahid H Shah   +41 more
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SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [PDF]

, 2010
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension
Handschin, C, Heinrich, Kathrin, Schäfer, N, Heinrich, K, Winnik, Stephan, Matter, Christian M., Brokopp, Chad E., Tanner, F C, Tanner, Felix C., Landmesser, Ulf, Breitenstein, A, Handschin, Christoph, Stein, Sokrates, Landmesser, U, Lüscher, Thomas F., Breitenstein, Alexander, Schäfer, Nicola, Besler, C, Winnik, S, Lohmann, C, Lüscher, T F, Lohmann, Christine, Besler, Christian, Matter, C M, Brokopp, C E, Stein, S   +25 more
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HEX ameliorates S. aureus-induced inflammation in MMECs through PPARα-SIRT1-NF-κB axis. [PDF]

, 2023
A-F and H. GW6471 (25 μM) and HEX (5 μM) were performed for 2 h followed by S. aureus (105 CFU) treatment for the next 24 h. A. The relative intensities of PPARα was analyzed by western blotting (n = 5). B-D.
Lianjun Feng (11177968), Xiaoyu Hu (4159), Shiyu Duan (15310003), Caijun Zhao (6741056), Yihong Zhao (577669), Lijuan Bao (11177965), Shan Shang (17373678), Keyi Wu (1719538), Naisheng Zhang (560130), Jiawen Xu (4277224), Yunhe Fu (3603749), Hao Sun (14095), Min Qiu (324481), Ruping Shan (17373681)   +13 more
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SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
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SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression? [PDF]

, 2021
Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy.
Shailendra Anoopkumar-Dukie, Andrew Keith Davey, Zhang, Y, Anoopkumar-Dukie, S, Yuqing Zhang, Davey, AK   +5 more
core   +1 more source

Roles of SIRT1 in leukemogenesis [PDF]

Current Opinion in Hematology, 2013
This review provides a concise summary of significant research progress on SIRT1 deacetylase in leukemia in the past year. SIRT1 is a multifunctional protein and recent studies demonstrate that SIRT1 plays a crucial role in myeloid leukemogenesis and drug resistance.SIRT1 expression is typically low in normal adult hematopoietic stem/progenitor cells ...
WenYong, Chen, Ravi, Bhatia
openaire   +2 more sources

SIRT1-ER mRNA and protein in sirt1^+/ER and sirt1^ER/ER tissues. [PDF]

, 2017
A. Levels of mRNA from the sirt1ER gene are higher than those from sirt1+. RNA was isolated from brain, liver and testes of sirt1ER/ER and sirt1+/+ mice and used for quantitative assessment of SIRT1 mRNA levels by comparative PCR.
Annabelle Z. Caron (2692186), Michael W. McBurney (88116), Xiaohong He (646305), Danielle Dewar-Darch (275442), Karen Jardine (88113), Katherine V. Clark-Knowles (368164), Josée Coulombe (3821293), Douglas A. Gray (241998)   +7 more
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