Results 11 to 20 of about 77,206 (307)

MicroRNA Regulation of SIRT1 [PDF]

Frontiers in Physiology, 2012
SIRT1 is an NAD-dependent deacetylase that regulates stress response pathways. By deacetylating transcription factors and co-factors, SIRT1 modulates metabolism, inflammation, hypoxic responses, circadian rhythms, cell survival, and longevity. Since SIRT1 plays a key role in regulating pathways involved in cardiovascular diseases and metabolic diseases
Munekazu eYamakuchi, Munekazu Yamakuchi
openaire   +4 more sources

Rejuvenating SIRT1 Activators [PDF]

Cell Metabolism, 2013
Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.
Gut, Philipp, Verdin, Eric
openaire   +4 more sources

SIRT1, metabolism and cancer

Current Opinion in Oncology, 2012
SIRT1 impacts upon diverse cellular processes via its roles in the determination of chromatin structure, chromatin remodelling and gene expression. This review covers the recent discoveries linking SIRT1 with the regulation of mammalian metabolism and considers ways in which abnormal metabolism in disease may, in turn, impact upon SIRT1 because of ...
John R P, Knight, Jo, Milner
openaire   +3 more sources

LncRNA Sirt1-AS Protects Against Cardiac Hypertrophy by Modulating Sirt1

Journal of Cardiovascular Pharmacology and Therapeutics
Background LncRNAs are pivotal regulators in cardiovascular diseases. Sirt1-AS, a lncRNA, has been shown to play a role in cardiovascular diseases. This study aimed to explore the role of Sirt1-AS in cardiac hypertrophy and the underlying molecular mechanism.
Xuejiao Wei, Chenrui Zhang, Shuanglong Mou, Yongqin He, Xiaoyun Si, Bing Li   +5 more
openaire   +3 more sources

Fibrillarin Resists Cellular Senescence Via SIRT1-Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma. [PDF]

Adv Sci (Weinh)
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Jin X, Liu H, Gao L, Liu L, Liu JB, Jin X, Wang MS, Liu D, Feng L, Chen WL.   +9 more
europepmc   +2 more sources

Nicotinamide Metabolism Constrains Memory CD8⁺ T Cell Formation Through a Putative HS1BP3-SIRT1-FOXO3-BCL6 Axis. [PDF]

Adv Sci (Weinh)
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Wang S, Fan X, Huang Y, Yao C, Fan J, Ping Y, Zhao X, Li C, Shen C, Shan J, Liu J, Wang S, Zhang Z, Zhang Y.   +13 more
europepmc   +2 more sources

Regulation of SIRT1 by MicroRNAs [PDF]

Molecules and Cells, 2013
Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to ...
Sung-E, Choi, Jongsook Kim, Kemper
openaire   +2 more sources

SIRT1 and Kidney Function [PDF]

Kidney Diseases, 2015
<b><i>Background:</i></b> SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology.
Yi, Guan, Chuan-Ming, Hao
openaire   +2 more sources

The Role of Sirt1 in Epileptogenesis [PDF]

eneuro, 2017
AbstractThe mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased metabolic demand or decreased energy supply.
Alicia M. Hall, Gary P. Brennan, Tiffany M. Nguyen, Akanksha Singh-Taylor, Hyun-Seung Mun, Mary J. Sargious, Tallie Z. Baram   +6 more
openaire   +4 more sources

MiR-138 promotes apoptosis of colon cancer cells by targeting SIRT1

Di-san junyi daxue xuebao, 2021
Objective To investigate the mechanism of miR-138 involving in the apoptosis of colon cancer cells by regulating SIRT1. Methods RT-qPCR was used to detect the expression of miR-138 in colon cancer cell lines HCT 116, SW480, Caco-2, HT29 and SW1116.
YANG Yang, PENG Wenli
doaj   +1 more source