Results 11 to 20 of about 72,220 (305)
Aerobic Exercise-Mimetic Effects of Resveratrol on the Prevention of Vascular Endothelial Senescence [PDF]
운동과학, 2023 PURPOSE Regular exercise has been shown to have anti-aging effects on the vascular system by improving endothelial function and diminishing oxidative stress.
Ji-Seok Kim
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Food & Nutrition Research, 2022 Background: Resveratrol, a well-known natural compound and nutrient, activates the deacetylation ability of SIRT1, demonstrating p53-dependent apoptosis functions in many diseases. However, the nascent proteomic fluctuation caused by resveratrol is still
Tian Su +6 more
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Supplementary Material for: Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPKα-SIRT1-PGC-1α Pathway [PDF]
, 2022 Introduction: Our previous studies have demonstrated advanced glycation end products (AGEs) was an important mediator in osteoarthritis (OA) which may induce mitochondrial dysfunction.
Yang Q. (4154716) +4 more
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Journal of Investigative Surgery, 2022 Background: The activation of alveolar macrophages (AMs) modulated via leucine-rich repeat (NLR) pyrin domain containing 3 (NLRP3) inflammasome activation is key to the progression of renal ischemia/reperfusion (rI/R)-mediated acute lung injury (ALI ...
Zhaohui Liu +6 more
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SIRT1 and Kidney Function [PDF]
Kidney Diseases, 2015 <b><i>Background:</i></b> SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology.
Yi, Guan, Chuan-Ming, Hao
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Luteolin alleviates sepsis-induced cardiac injury by activating SIRT1
陆军军医大学学报, 2022 Objective To explore the effect and mechanism of luteolin (LTN) in sepsis-induced cardiac injury. Methods Caecal ligation perforation (CLP) was used to establish a septic model in mice, and 42 mice were randomly divided into Sham group, CLP group and ...
LIU Bin, LONG Jun, SI Liangyi
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The Role of Sirt1 in Epileptogenesis [PDF]
eneuro, 2017 AbstractThe mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased metabolic demand or decreased energy supply.
Alicia M. Hall +6 more
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MiR-138 promotes apoptosis of colon cancer cells by targeting SIRT1
Di-san junyi daxue xuebao, 2021 Objective To investigate the mechanism of miR-138 involving in the apoptosis of colon cancer cells by regulating SIRT1. Methods RT-qPCR was used to detect the expression of miR-138 in colon cancer cell lines HCT 116, SW480, Caco-2, HT29 and SW1116.
YANG Yang, PENG Wenli
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Vinca herbacea Extract Suppresses NF-kB Signaling and Modulates SIRT1/AMPK/PGC1α Axis to Exert Antidiabetic Effects in Streptozotocin- Induced Diabetic Rats [PDF]
Research Journal of Pharmacognosy, 2022 Background and Objectives: AMPK/SIRT1/PGC1α signaling pathway has an important role in diabetic condition. Some natural products exert anti-diabetic effects by modulating this pathway and also by inhibition of NF-κB. Vinca herbacea has potent antioxidant
Nasim Abedimanesh +13 more
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MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
Biotechnology & Biotechnological Equipment, 2020 Vitiligo is caused by the disappearance of melanocyte function in the skin, but the mechanism has not been fully elucidated. This study aimed to investigate the expression and role of miR-217 in dysfunctional human primary melanocytes caused by oxidative
Bo Huang, Xuecheng Sun, Aie Xu
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