Results 11 to 20 of about 65,348 (268)
Regulation of SIRT1 by MicroRNAs [PDF]
Molecules and Cells, 2013 Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to ...
Sung-E, Choi, Jongsook Kim, Kemper
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SIRT1 and Kidney Function [PDF]
Kidney Diseases, 2015 <b><i>Background:</i></b> SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology.
Yi, Guan, Chuan-Ming, Hao
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The Role of Sirt1 in Epileptogenesis [PDF]
eneuro, 2017 AbstractThe mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased metabolic demand or decreased energy supply.
Alicia M. Hall +6 more
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MiR-138 promotes apoptosis of colon cancer cells by targeting SIRT1
Di-san junyi daxue xuebao, 2021 Objective To investigate the mechanism of miR-138 involving in the apoptosis of colon cancer cells by regulating SIRT1. Methods RT-qPCR was used to detect the expression of miR-138 in colon cancer cell lines HCT 116, SW480, Caco-2, HT29 and SW1116.
YANG Yang, PENG Wenli
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Vinca herbacea Extract Suppresses NF-kB Signaling and Modulates SIRT1/AMPK/PGC1α Axis to Exert Antidiabetic Effects in Streptozotocin- Induced Diabetic Rats [PDF]
Research Journal of Pharmacognosy, 2022 Background and Objectives: AMPK/SIRT1/PGC1α signaling pathway has an important role in diabetic condition. Some natural products exert anti-diabetic effects by modulating this pathway and also by inhibition of NF-κB. Vinca herbacea has potent antioxidant
Nasim Abedimanesh +13 more
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MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
Biotechnology & Biotechnological Equipment, 2020 Vitiligo is caused by the disappearance of melanocyte function in the skin, but the mechanism has not been fully elucidated. This study aimed to investigate the expression and role of miR-217 in dysfunctional human primary melanocytes caused by oxidative
Bo Huang, Xuecheng Sun, Aie Xu
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The Role of SIRT1 in Tumorigenesis [PDF]
American Chinese Journal of Medicine and Science, 2011 NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones.
Kai Li, Jianyuan Luo, Gissou Azabdaftari
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Autoimmunity, 2021 Background Recent studies have provided strong evidence that lncRNAs play a functional regulatory role in diabetic retinopathy (DR). The purpose of this study was to investigate the effect of long non-coding RNA (lncRNA) X-inactive specific transcript ...
Jiayu Zhang +5 more
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Dietary activators of Sirt1 [PDF]
Molecular and Cellular Endocrinology, 2009 Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1.
Joanne S, Allard +3 more
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Molecular Cell, 2008 In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
Blazek, Dalibor, Peterlin, B. Matija
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