Results 11 to 20 of about 114,000 (255)
Biogenesis of mitochondrial proteins [PDF]
Current Opinion in Cell Biology, 1996 Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
R, Lill, F E, Nargang, W, Neupert
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Mitochondrial biogenesis: An update [PDF]
Journal of Cellular and Molecular Medicine, 2020 Abstract In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing.
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MYC and Mitochondrial Biogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction,
Fionnuala, Morrish, David, Hockenbery
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Mitochondrial biogenesis and turnover [PDF]
Cell Calcium, 2008 Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover. The mechanisms associated with these events have been intensively studied in the last 20 years and our understanding of their details is much improved ...
Francisca, Diaz, Carlos T, Moraes
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Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. [PDF]
PLoS ONE, 2008 DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated).
Xuan Fu +4 more
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Regulation of mitochondrial biogenesis [PDF]
Essays in Biochemistry, 2010 Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only recently been elucidated. Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer’s disease.
François R, Jornayvaz +1 more
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Biology, 2021 The five-sixth nephrectomy (5/6Nx) model is widely used to study the mechanisms involved in chronic kidney disease (CKD) progression. Mitochondrial impairment is a critical mechanism that favors CKD progression.
Rodrigo Prieto-Carrasco +8 more
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Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Increasing evidence implicates impaired mitochondrial biogenesis as an important contributor to mitochondrial dysfunction, which plays a central role in the pathogenesis of neurodegenerative diseases including Parkinson’s disease (PD).
Muhammet Ay
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In situ observation of mitochondrial biogenesis as the early event of apoptosis
iScience, 2021 Summary: Mitochondrial biogenesis is a cell response to external stimuli which is generally believed to suppress apoptosis. However, during the process of apoptosis, whether mitochondrial biogenesis occurs in the early stage of the apoptotic cells ...
Chang-Sheng Shao +5 more
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Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. [PDF]
PLoS ONE, 2012 Supplementation of selenium has been shown to protect cells against free radical mediated cell damage. The objectives of this study are to examine whether supplementation of selenium stimulates mitochondrial biogenesis signaling pathways and whether ...
Natalia Mendelev +4 more
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