Results 11 to 20 of about 535,437 (290)
Mitochondrial biogenesis and turnover [PDF]
Cell Calcium, 2008 Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover. The mechanisms associated with these events have been intensively studied in the last 20 years and our understanding of their details is much improved ...
Francisca, Diaz, Carlos T, Moraes
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Regulation of mitochondrial biogenesis [PDF]
Essays in Biochemistry, 2010 Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only recently been elucidated. Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer’s disease.
François R, Jornayvaz +1 more
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Mitochondrial biogenesis and healthy aging [PDF]
Experimental Gerontology, 2008 Aging is associated with an overall loss of function at the level of the whole organism that has origins in cellular deterioration. Most cellular components, including mitochondria, require continuous recycling and regeneration throughout the lifespan.
López-Lluch, Guillermo +3 more
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Frontiers in Molecular Biosciences, 2021 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has been shown to play a pivotal role in the regulation of mitochondrial biogenesis in diseases.
Jian Zhou +7 more
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Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. [PDF]
PLoS ONE, 2014 BACKGROUND AND PURPOSE: Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion.
Yuying Xie +4 more
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Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. [PDF]
PLoS ONE, 2008 DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated).
Xuan Fu +4 more
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Chaperoning mitochondrial biogenesis. [PDF]
, 1994 Langer, Thomas, Neupert, Walter
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Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]
, 1994 Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Herrmann, Johannes M. +3 more
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Biology, 2021 The five-sixth nephrectomy (5/6Nx) model is widely used to study the mechanisms involved in chronic kidney disease (CKD) progression. Mitochondrial impairment is a critical mechanism that favors CKD progression.
Rodrigo Prieto-Carrasco +8 more
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Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Increasing evidence implicates impaired mitochondrial biogenesis as an important contributor to mitochondrial dysfunction, which plays a central role in the pathogenesis of neurodegenerative diseases including Parkinson’s disease (PD).
Muhammet Ay
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