Results 21 to 30 of about 123,664 (300)
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
eLife, 2022 Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu +5 more
doaj +1 more source
Cell Communication and Signaling, 2023 Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu +9 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has been shown to play a pivotal role in the regulation of mitochondrial biogenesis in diseases.
Jian Zhou +7 more
doaj +1 more source
Chaperoning mitochondrial biogenesis. [PDF]
, 1994 Langer, Thomas, Neupert, Walter
openaire +3 more sources
Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. [PDF]
PLoS ONE, 2014 BACKGROUND AND PURPOSE: Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion.
Yuying Xie +4 more
doaj +1 more source
Mitochondrial biogenesis: An update [PDF]
Journal of Cellular and Molecular Medicine, 2020 Abstract In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing.
openaire +2 more sources
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. [PDF]
PLoS ONE, 2008 DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated).
Xuan Fu +4 more
doaj +1 more source
MYC and Mitochondrial Biogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction,
Fionnuala, Morrish, David, Hockenbery
openaire +2 more sources
Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Increasing evidence implicates impaired mitochondrial biogenesis as an important contributor to mitochondrial dysfunction, which plays a central role in the pathogenesis of neurodegenerative diseases including Parkinson’s disease (PD).
Muhammet Ay
doaj +1 more source
Biology, 2021 The five-sixth nephrectomy (5/6Nx) model is widely used to study the mechanisms involved in chronic kidney disease (CKD) progression. Mitochondrial impairment is a critical mechanism that favors CKD progression.
Rodrigo Prieto-Carrasco +8 more
doaj +1 more source