Results 21 to 30 of about 114,000 (255)

PGC-1α overexpression promotes mitochondrial biogenesis to protect auditory cells against cisplatin-induced cytotoxicity

Journal of Bio-X Research, 2019
. Cisplatin (CDDP)-induced ototoxicity is one of the common adverse effects of cisplatin chemotherapy. Thus far, effective approaches for attenuating hearing loss are unavailable in clinical practice.
Weijian Zhang, Hao Xiong, Jiaqi Pang, Lan Lai, Zhongwu Su, Hanqing Lin, Bingquan Jian, Haidi Yang, Yiqing Zheng   +8 more
doaj   +1 more source

5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation

Frontiers in Pharmacology, 2022
Neuropathic pain is a devastating disease that affects millions of people worldwide. Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation.
Long-Qing Zhang, Ya-Qun Zhou, Jia-Yan Li, Jia Sun, Shuang Zhang, Jia-Yi Wu, Shao-Jie Gao, Xue-Bi Tian, Wei Mei   +8 more
doaj   +1 more source

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7

EMBO Molecular Medicine, 2019
Nuclear and mitochondrial genome mutations lead to various mitochondrial diseases, many of which affect the mitochondrial respiratory chain. The proteome of the intermembrane space (IMS) of mitochondria consists of several important assembly factors that
Karthik Mohanraj, Michal Wasilewski, Cristiane Benincá, Dominik Cysewski, Jaroslaw Poznanski, Paulina Sakowska, Zaneta Bugajska, Markus Deckers, Sven Dennerlein, Erika Fernandez‐Vizarra, Peter Rehling, Michal Dadlez, Massimo Zeviani, Agnieszka Chacinska   +13 more
doaj   +1 more source

MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation

Autophagy Reports, 2022
Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are ...
Priyanka Gajwani, Jalees Rehman
doaj   +1 more source

Biogenesis of mitochondrial ATPase [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1977
No abstract ...
openaire   +3 more sources

Biogenesis of Mitochondrial Metabolite Carriers [PDF]

Biomolecules, 2020
Metabolite carriers of the mitochondrial inner membrane are crucial for cellular physiology since mitochondria contribute essential metabolic reactions and synthesize the majority of the cellular ATP. Like almost all mitochondrial proteins, carriers have to be imported into mitochondria from the cytosol.
Patrick Horten, Lilia Colina-Tenorio, Heike Rampelt   +2 more
openaire   +4 more sources

Potensi Konsumsi Kunyit Dalam Rangka Meningkatkan Performa Olahraga Melalui Peningkatan Mitokondria Biogenesis Otot Skelet

Jurnal Pendidikan Jasmani dan Olahraga, 2018
One of physical adaptation at cell level is known as mitochondrial biogenesis. Sport endurance could increase the metabolic characteristic in skeletal muscle, including mitochondrial biogenesis and glucose transporter 4 (GLUT4) improvement.
Hamidie Ronald Daniel Ray, Kazumi Masuda
doaj   +1 more source

Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes

Ecotoxicology and Environmental Safety, 2021
Improper treatment of a large amount of industrial waste makes hexavalent chromium [Cr(VI)] seriously pollute the atmosphere, soil and water, and enter the food chain, seriously affecting the health of workers and local residents.
Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xiao   +6 more
doaj   +1 more source

Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome

Nature Communications, 2023
Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins.
Thu Giang Nguyen, Christina Ritter, Eva Kummer   +2 more
doaj   +1 more source

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

mBio, 2016
Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids.
S. Karniely, M. P. Weekes, R. Antrobus, J. Rorbach, L. van Haute, Y. Umrania, D. L. Smith, R. J. Stanton, M. Minczuk, P. J. Lehner, J. H. Sinclair   +10 more
doaj   +1 more source