Results 41 to 50 of about 1,226,681 (303)

Effects of carotenoids on mitochondrial dysfunction [PDF]

Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection.
Dias, I. H. K., Oyebode, O., Edward, R., Griffiths, H., Ademowo, S., Conway, M.   +5 more
core   +3 more sources

Mitochondrial dysfunction in heart failure and its therapeutic implications

Frontiers in Cardiovascular Medicine, 2022
The ATP consumption in heart is very intensive to support muscle contraction and relaxation. Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been believed as the primary mechanism responsible for the inability of energy ...
Miaosen Liu, Jialan Lv, Zhicheng Pan, Dongfei Wang, Liding Zhao, Xiaogang Guo   +5 more
doaj   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +2 more sources

Mitochondrial Dysfunction in Parkinson’s Disease [PDF]

Experimental Neurobiology, 2015
Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective mitochondrial function and increased oxidative stress (OS) have been demonstrated as having an important role in PD pathogenesis, although the underlying mechanism is not clear ...
Moon, Hyo Eun, Paek, Sun Ha
openaire   +2 more sources

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K., Jane P Toegel, Jane P. Toegel (185544), Winklhofer Konstanze F., A Kathrin Lutz, Voigt Aaron, Falkenburger, Bjoern, Toegel Jane P., Konstanze F. Winklhofer (185550), Gerhardt, Ellen, Karsten Peter, A. Kathrin Lutz (185542), Voigt, Aaron, Butler Erin K., Toegel, Jane P., Peter Karsten (123433), Björn Falkenburger (185548), Schulz, Joerg B., Falkenburger, Bjoern H., Peter Karsten, Ellen Gerhardt (185546), Andrea Reinartz (185549), Reinartz, Andrea, Erin K Butler, Ellen Gerhardt, Lutz A. Kathrin, Jörg B Schulz, Gerhardt Ellen, Aaron Voigt (123446), Reinartz Andrea, Jörg B. Schulz (123442), Lutz, A. Kathrin, Karsten, Peter, Konstanze F Winklhofer, Aaron Voigt, Björn Falkenburger, Schulz Jörg B., Erin K. Butler (185540), Winklhofer, Konstanze F., Falkenburger Björn, Andrea Reinartz, Toegel, Jane Patricia   +41 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mitochondrial protein dysfunction in pathogenesis of neurological diseases [PDF]

, 2022
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal ...
Yang, Cheng, Wu, Qiong, He, Xiumei, Zhou, Zuping, Yang, Ziyun, Pu, Shiming, Cen, Xiaobo, Wang, Liang, Zhao, Hongxia   +8 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mitigating mitochondrial dysfunction: a novel strategy for Chinese botanical drugs against osteoporosis

Frontiers in Pharmacology
Osteoporosis (OP) is a chronic metabolic disease characterized by reduced bone mass and impaired bone microstructure, posing a significant global health threat.
Shiyu Li, Hongyu Liu
doaj   +1 more source