Results 1 to 10 of about 184,138 (308)

The dynamics of mitochondrial Ca2+ fluxes [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
We have investigated the kinetics of mitochondrial Ca(2+) influx and efflux and their dependence on cytosolic [Ca(2+)] and [Na(+)] using low-Ca(2+)-affinity aequorin. The rate of Ca(2+) release from mitochondria increased linearly with mitochondrial [Ca(2+)] ([Ca(2+)](M)).
Fuente Pérez, Sergio De La, Montenegro, Pablo, Fonteriz García, Rosalba Inés, Moreno Díaz-Calderón, Alfredo, Domínguez Lobatón, María Carmen, Montero Zoccola, María Teresa, Álvarez Martín, Javier   +6 more
openaire   +5 more sources

Proteolytic regulation of mitochondrial dynamics

Mitochondrion, 2019
Spatiotemporal changes in the abundance, shape, and cellular localization of the mitochondrial network, also known as mitochondrial dynamics, are now widely recognized to play a key role in mitochondrial and cellular physiology as well as disease states.
Jonathan V, Dietz, Iryna, Bohovych, Martonio Ponte, Viana, Oleh, Khalimonchuk   +3 more
openaire   +3 more sources

Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration

Frontiers in Molecular Neuroscience, 2019
Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metabolic
Darren O’Hara, Gavin M. Davis, Natalie A. Adlesic, Jerrard M. Hayes, Gavin P. Davey   +4 more
doaj   +1 more source

Targeting the mitochondrial metabolite-dynamics-MDVs-MitoEVs axis: a new frontier in osteoarthritis management

Journal of Translational Medicine
Background Osteoarthritis (OA) is characterized by progressive cartilage degradation, osteophyte formation, and synovitis. OA progression is linked to mitochondrial metabolic dysfunction, marked by tricarboxylic acid (TCA) cycle imbalance and impaired ...
Taotao Zhang, Hongmei Zhang, Xinzhao Chen, Yingxiang Liu, Xiaoxiao Han, Weiwei Zhu, Yubo Liu, Guang Zeng, Kai Jiao   +8 more
doaj   +1 more source

Modulation of Mitochondrial Dynamics in Neurodegenerative Diseases: An Insight Into Prion Diseases

Frontiers in Aging Neuroscience, 2018
Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart.
Ting Zhu, Ji-Long Chen, Qingsen Wang, Wenhan Shao, Baomin Qi   +4 more
doaj   +1 more source

Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance

Nature Communications
Tissue regeneration is a complex process involving large changes in cell proliferation, fate determination, and differentiation. Mitochondrial dynamics and metabolism play a crucial role in development and wound repair, but their function in large-scale ...
Xue Pan, Yun Zhao, Yucong Li, Jiajia Chen, Wenya Zhang, Ling Yang, Yuanyi Zhou Xiong, Yuqing Ying, Hao Xu, Yuhong Zhang, Chong Gao, Yuhan Sun, Nan Li, Liangyi Chen, Zhixing Chen, Kai Lei   +15 more
doaj   +1 more source

Possible Role of Novel Mitochondrial Subsets in Migraine

Life
Migraine is a complex neurological disorder characterized by recurrent headaches and sensory disturbances. Emerging evidence highlights a critical role for mitochondrial dysfunction in migraine pathophysiology, including impairments in oxidative ...
Ozgur Yildirim Savran, Meltem Tuncer
doaj   +1 more source

A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells

Stem Cell Reports, 2018
Summary: Human pluripotent stem cells (hPSCs) maintain a highly fragmented mitochondrial network, but the mechanisms regulating this phenotype remain unknown. Here, we describe a non-cell death function of the anti-apoptotic protein, MCL-1, in regulating
Megan L. Rasmussen, Leigh A. Kline, Kyungho P. Park, Natalya A. Ortolano, Alejandra I. Romero-Morales, Christin C. Anthony, Kathryn E. Beckermann, Vivian Gama   +7 more
doaj   +1 more source

Metabolic regulation of mitochondrial morphologies in pancreatic beta cells: coupling of bioenergetics and mitochondrial dynamics

Communications Biology
Cellular bioenergetics and mitochondrial dynamics are crucial for the secretion of insulin by pancreatic beta cells in response to elevated levels of blood glucose.
Wen-Wei Tseng, Ching-Hsiang Chu, Yi-Ju Lee, Shirui Zhao, Chen Chang, Yi-Ping Ho, An-Chi Wei   +6 more
doaj   +1 more source

Critical role of mitochondrial dynamics in chronic respiratory diseases and new therapeutic directions

Chinese Medical Journal
. Chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) are both chronic progressive respiratory diseases that cannot be completely cured.
Xiaomei Wang, Ziming Zhu, Haocheng Jia, Xueyi Lu, Yingze Zhang, Yingxin Zhu, Jinzheng Wang, Yanfang Wang, Rubin Tan, Jinxiang Yuan, Yanjie Yin   +10 more
doaj   +1 more source