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Mitochondrial dynamics and mitochondrial quality control
Redox Biology, 2015 Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis
Hong-Min Ni +2 more
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Frontiers in Cardiovascular Medicine, 2022 The heart is dependent on ATP production in mitochondria, which is closely associated with cardiovascular disease because of the oxidative stress produced by mitochondria. Mitochondria are highly dynamic organelles that constantly change their morphology
Yoshihiro Uchikado +2 more
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Frontiers in Cell and Developmental Biology, 2021 BackgroundCancer-associated cachexia (CAC) is a syndrome characterized by skeletal muscle atrophy, and the underlying mechanisms are still unclear. Recent research studies have shed light on a noteworthy link between mitochondrial dynamics and muscle ...
Xiangyu Mao +9 more
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Animal Cells and Systems, 2021 Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer ...
Youngsook Choi +6 more
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Frontiers in Cellular Neuroscience, 2016 Axon degeneration is a prominent feature of various neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, and is often characterized by aberrant mitochondrial dynamics.
Gregory Berbusse +3 more
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Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Biology Open, 2020 Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte +5 more
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Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. [PDF]
PLoS Biology, 2016 Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics.
Michal Cagalinec +12 more
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Research in Cardiovascular Medicine, 2018 Mitochondria as dynamic organelle constantly undergo fusion and fission reactions, leading to continuous reconstruction of the mitochondrial network for elongated or fragmentation shapes and ultimately the mitophagy.
Babak Ebadi +4 more
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Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model. [PDF]
PLoS ONE, 2013 Mitochondria are dynamic organelles that constantly undergo fusion and fission to maintain their normal functionality. Impairment of mitochondrial dynamics is implicated in various neurodegenerative disorders.
Guo Luo +6 more
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Unveiling the potential of mitochondrial dynamics as a therapeutic strategy for acute kidney injury
Frontiers in Cell and Developmental Biology, 2023 Acute Kidney Injury (AKI), a critical clinical syndrome, has been strongly linked to mitochondrial malfunction. Mitochondria, vital cellular organelles, play a key role in regulating cellular energy metabolism and ensuring cell survival.
Yajie Hao +4 more
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