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Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders

Membranes, 2022
Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi, Azza Salah, Ayman W. El-Hattab   +2 more
doaj   +3 more sources

Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]

Toxicology, 2017
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N. Meyer
exaly   +3 more sources

Mitochondrial fission during mitophagy requires both inner and outer mitofissins [PDF]

EMBO Reports
Mitophagy maintains mitochondrial homeostasis through the selective degradation of damaged or excess mitochondria. Recently, we identified mitofissin/Atg44, a mitochondrial intermembrane space-resident fission factor, which directly acts on lipid ...
Kentaro Furukawa, Tatsuro Maruyama, Yuji Sakai, Shun-ichi Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Nobuo N Noda, Tomotake Kanki   +7 more
doaj   +2 more sources

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Redox Biology, 2018
Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury.
Qinhua Jin, Ruibing Li, Nan Hu, Ting Xin, Pingjun Zhu, Shunying Hu, Sai Ma, Hong Zhu, Jun Ren, Hao Zhou   +9 more
doaj   +3 more sources

Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients. [PDF]

J Inflamm Res
The glomerular injury is associated with different pathogeneses, and podocyte damage is common in various ISN/RPS class lupus nephritis (LN). In podocyte, mitochondrial morphological changes are observed in lupus nephritis (LN) in our previous study. This study aimed to explore mitochondrial fission proteins expression in podocytes using bioinformatics
Wei Q, Wu X, Chen Z, Lin H, Xiong L, Wang N.   +5 more
europepmc   +3 more sources

RETRACTED: Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation

Frontiers in Cell and Developmental Biology, 2021
Although mitochondrial fission has been reported to increase proliferative capacity and collagen production, it can also contribute to mitochondrial impairment, which is detrimental to cell survival.
Qing-Yuan Gao, Qing-Yuan Gao, Hai-Feng Zhang, Hai-Feng Zhang, Jun Tao, Zhi-Teng Chen, Zhi-Teng Chen, Chi-Yu Liu, Chi-Yu Liu, Wen-Hao Liu, Wen-Hao Liu, Mao-Xiong Wu, Mao-Xiong Wu, Wen-Yao Yin, Wen-Yao Yin, Guang-Hao Gao, Guang-Hao Gao, Yong Xie, Yong Xie, Ying Yang, Ying Yang, Pin-Ming Liu, Pin-Ming Liu, Jing-Feng Wang, Jing-Feng Wang, Yang-Xin Chen, Yang-Xin Chen   +26 more
doaj   +1 more source

Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation

Cell Death and Disease, 2022
Previous studies have demonstrated dysregulated mitochondrial dynamics in fibrotic livers and hepatocytes. Little is currently known about how mitochondrial dynamics are involved, nor is it clear how mitochondrial dynamics participate in hepatic stellate
Yanni Zhou, Dan Long, Ying Zhao, Shengfu Li, Yan Liang, Lin Wan, Jingyao Zhang, Fulai Xue, Li Feng   +8 more
doaj   +1 more source

Mitochondrial fission and fusion [PDF]

Essays in Biochemistry, 2010
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
openaire   +2 more sources

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Nature Communications, 2023
Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi   +11 more
doaj   +1 more source

Mitochondrial membrane tension governs fission [PDF]

Cell Reports, 2018
Abstract During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide, or reverse upon disassembly of the machinery. However, a role for membrane tension in mitochondrial fission, although speculated,
Mahecic, Dora, Carlini, Lina, Kleele, Tatjana, Colom Diego, Adai, Goujon, Antoine, Matile, Stefan, Roux, Aurélien, Manley, Suliana   +7 more
openaire   +7 more sources