Results 1 to 10 of about 1,174,031 (334)
PLoS Genetics, 2010 miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis.
Jincheng Li +5 more
doaj +1 more source
iScience, 2023 Summary: Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells.
Brock A. Humphries +7 more
doaj +1 more source
Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis.
Cancer Research, 2022 Micropeptides are a recently discovered class of molecules that play vital roles in various cellular processes, including differentiation, proliferation, and apoptosis.
Chen Xie +10 more
semanticscholar +1 more source
BMC Cell Biology, 2018 Background Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis.
Sayilaxi Jieensinue +5 more
doaj +1 more source
Cell Death and Disease, 2022 Cadmium is one of the environmental and occupational pollutants and its potential adverse effects on human health have given rise to substantial concern. Cadmium causes damage to the male reproductive system via induction of germ-cell apoptosis; however,
Ling-Na Yi +8 more
semanticscholar +1 more source
Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis
Signal Transduction and Targeted Therapy, 2021 Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network ...
Yan Yu +20 more
semanticscholar +1 more source
FEBS Open Bio, 2021 Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan +6 more
doaj +1 more source
ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation.
Pharmacological Research, 2022 Mitochondrial metabolism plays a pivotal role in various cellular processes and fibrosis. However, the mechanism underlying mitochondrial metabolic function and liver fibrosis remains poorly understood.
Juan Wang +9 more
semanticscholar +1 more source
Cell Proliferation, 2021 High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) and critically ...
Wei Feng +12 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2018 Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis.
Jia Qi +10 more
doaj +1 more source