Results 1 to 10 of about 22,459 (190)
Frontiers in Cell and Developmental Biology, 2021 Drp1 is a central player in mitochondrial fission and is recruited to mitochondria by Mff and MIEFs (MIEF1 and MIEF2), but little is known about how its assembly state affects Drp1 mitochondrial recruitment and fission.
Rong Yu, Shao-Bo Jin, Urban Lendahl
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A novel small molecule inhibitor of human Drp1 [PDF]
Scientific Reports, 2022 Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes.
Ayeshah A. Rosdah +12 more
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Exercise as a Bidirectional Regulator of Drp1: A Goldilocks Principle for Mitochondrial Adaptation in Skeletal Muscle [PDF]
CellsDynamin-related protein 1 (Drp1) is essential for mitochondrial dynamics in skeletal muscle, particularly in regulating fission, mitophagy, and maintaining mitochondrial function.
Mei Ma +5 more
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Molecular Oncology, 2022 Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role of DRP1 in head and neck cancer (HNC) are currently poorly understood.
Tai-Lin Huang, Chien-Chung Chang
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, 2013 Drp1<strong>Tilt Series Date:</strong> 2013-01-01</p> <strong>Data Taken By:</strong> Elitza Tocheva</p> <strong>Species / Specimen:</strong> Drp1</p> <strong>Strain:</strong> </p> ...
Tocheva, Elitza
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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission [PDF]
Drug Design, Development and TherapyYingxue Sun,1,* Shi Jin,1,* Jun Chen,2,* Jian Zhang,1 Yufei Lu,1 Qiuyu Gu,1 Zhixin Yan,1 Weize Chen,1 Annan Chen,1 Yi Fang,1 Wenye Geng,3 Xialian Xu,1 Nana Song1 1Department of Nephrology, Zhongshan Hospital, Fudan University; Shanghai ...
Sun Y +12 more
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New interfaces on MiD51 for Drp1 recruitment and regulation. [PDF]
PLoS ONE, 2019 Mitochondrial fission is facilitated by dynamin-related protein Drp1 and a variety of its receptors. However, the molecular mechanism of how Drp1 is recruited to the mitochondrial surface by receptors MiD49 and MiD51 remains elusive. Here, we showed that
Jun Ma +6 more
doaj +2 more sources
MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff [PDF]
Scientific Reports, 2017 Mitochondrial dynamics is a fundamental cellular process and recruitment of Drp1 to mitochondria is an essential step in mitochondrial fission. Mff and MIEF1/2 (MiD51/49) serve as key receptors for recruitment of Drp1 to mitochondria in mammals. However,
Rong Yu +6 more
doaj +2 more sources
Cells, 2021 High glucose (HG)-induced Drp1 overexpression contributes to mitochondrial dysfunction and promotes apoptosis in retinal endothelial cells. However, it is unknown whether inhibiting Drp1 overexpression protects against the development of retinal vascular
Dongjoon Kim +2 more
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Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth
Cell Reports, 2019 Summary: Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk ...
Sarbajeet Nagdas +2 more
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