Results 21 to 30 of about 22,509 (230)
SUMO wrestling with Drp1 at mitochondria [PDF]
The EMBO Journal, 2013 EMBO J 32 11: 1514–1528; March222013; 10.1038/emboj.2013.65 Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia.
Caroline A, Anderson, Craig, Blackstone
openaire +2 more sources
Kidney Diseases, 2022 Background: Sepsis causes acute kidney injury (AKI) in critically ill patients, although the mechanisms underlying the pathophysiology are not fully understood. SUMO-specific proteases 3 (SENP3), a member of the deSUMOylating enzyme family, is known as a
Lirui Wang, Jiangtao Li, Chen Yu
doaj +1 more source
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients
Biomolecules, 2020 Mitochondria are highly dynamic organelles that constantly fuse, divide, and move, and their function is regulated and maintained by their morphologic changes. Mitochondrial disease (MD) comprises a group of disorders involving mitochondrial dysfunction.
Takeshi Tokuyama +11 more
doaj +1 more source
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
doaj +1 more source
Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Biology Open, 2020 Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte +5 more
doaj +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells
Cells, 2020 Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1,
Liza Douiev +3 more
doaj +1 more source
Viruses, 2020 Mitochondrial dynamics is essential for the maintenance of cell homeostasis. Previous studies have shown that porcine circovirus 2 (PCV2) infection decreases the mitochondrial membrane potential and causes the elevation of reactive oxygen species (ROS ...
Yikai Zhang +3 more
doaj +1 more source
Drp1 is required for AgRP neuronal activity and feeding
eLife, 2021 The hypothalamic orexigenic Agouti-related peptide (AgRP)-expressing neurons are crucial for the regulation of whole-body energy homeostasis. Here, we show that fasting-induced AgRP neuronal activation is associated with dynamin-related peptide 1 (DRP1)-mediated mitochondrial fission and mitochondrial fatty acid utilization in AgRP
Sungho Jin +6 more
openaire +3 more sources
Sub-Cloning recombinant Drp1 into APEX2-GFP and overexpressing APEX2-GFP-Drp1 protein for potential mapping. [PDF]
, 2021 Drp1 regulation and mechanism in mammalian fission machinery have been extensively studied in an attempt to have a better understanding of the fission machinery mechanism, human diseases such as neurodegenerative ones that are associated with its ...
Bayarsaikhan, Emujin
core