Results 21 to 30 of about 19,581 (227)
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Animal Cells and Systems, 2021 Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer ...
Youngsook Choi +6 more
doaj +1 more source
Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system
Molecular Brain, 2020 Objectives Drp1 is widely expressed in the mouse central nervous system and plays a role in inducing the mitochondrial fission process. Many diseases are associated with Drp1 and mitochondria.
Ting-Ting Luo +8 more
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SENP3 Promotes an Mff-Primed Bcl-xL-Drp1 Interaction Involved in Cell Death Following Ischemia
Frontiers in Cell and Developmental Biology, 2021 Dysregulation of the mitochondrial fission machinery has been linked to cell death following ischemia. Fission is largely dependent on recruitment of Dynamin-related protein 1 (Drp1) to the receptor Mitochondrial fission factor (Mff) located on the ...
Chun Guo +7 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To explore the mechanism by which luteolin alleviates oxidative stress in mice with cerebral ischemia-reperfusion. Methods We screened the antioxidants with potential therapeutic effect on cerebral ischemia-reperfusion injury using CMap dataset
ZENG Xue +4 more
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The phosphorylation state of Drp1 determines cell fate [PDF]
The EMBO Reports, 2007 Recent research has opened new avenues for the evaluation of mitochondrial function; for example, mitochondria are no longer perceived as thread‐like static entities within the cytosol, but instead are viewed as highly dynamic organelles that can change in shape and size, and are transported to strategic locations within the cell.
Arezu, Jahani-Asl, Ruth S, Slack
openaire +2 more sources
Cells, 2020 Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival.
Yujia Liu +2 more
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Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
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Cell Death DiscoveryAbstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves ...
Nan Wang +4 more
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Sequestration puts Drp1 on furlough [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Drp1-x01 (green) localizes to microtubules (red). Strack et al. identify a splice variant of the mitochondrial fission protein Drp1 that can be sequestered away on microtubules.
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