Results 41 to 50 of about 22,509 (230)
Decreased Drp1 protein expression and Drp1-dependent mitochondrial fission. [PDF]
, 2012 (A) Mitochondrial morphology of NL20 (left) and A549 (right) cells following mito-DsRED transfection. Representative images shown: basal (upper) and following Drp1 RNAi (middle) or Drp1-YFP transfection (lower). The scale bar indicates 2 µm.
Kelly Jean Thomas (134283) +1 more
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Redox Biology, 2022 Mitochondria play an essential role in pathophysiology of both inflammatory and neuropathic pain (NP), but the mechanisms are not yet clear. Dynamin-related protein 1 (Drp1) is broadly expressed in the central nervous system and plays a role in the ...
Kun-Long Zhang +12 more
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Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer [PDF]
, 2021 Xiaohua Liang,1 Shengqiang Dang2 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Oncology, Chang’an Hospital of Xi’an, Xi&
Liang X, Dang S
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Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
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Changes in Ser616 phospho-Drp1 protein, and Drp1 gene expression in neurons following OGD. [PDF]
, 2013 Representative P-Drp1 immunoblots with the corresponding β-actin blots using standard (A) and non-denaturing (C) western blot protocol in control and OGD samples. P-Drp1 expression is high in control cells but it decreases following 3 h of OGD.
Somhrita Dutta (409386) +4 more
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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria [PDF]
Proceedings of the National Academy of Sciences, 2008 Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance between fusion and fission processes. Excessive fragmentation can be caused by inhibition of the fusion machinery and is a common consequence of dysfunction of the organelle. Here, we show a role for calcineurin-
CEREGHETTI GM +6 more
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Yeast two-hybrid assay identifying Drp1 inter-/intra- interaction and residue responsible for GSK3beta-Drp1 binding. [PDF]
, 2012 The design of the yeast two-hybrid assays showing interactions of various bait (pAS2-1) or prey (pACT2) constructs is indicated. The strength of interaction was assayed as described in Methods.
Ming-Chang Yang (117681) +14 more
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Drp1 is phosphorylated by GSK3beta at Ser693. [PDF]
, 2012 Drp1 is phosphorylated by GSK3beta. (A) Purified GSK3beta was used in an in vitro kinase assay to detect whether and which truncated His-tagged Drp1 proteins can act as a substrate to be phosphorylated by GSK3beta.
Ming-Chang Yang (117681) +14 more
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Sequestration puts Drp1 on furlough [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Drp1-x01 (green) localizes to microtubules (red). Strack et al. identify a splice variant of the mitochondrial fission protein Drp1 that can be sequestered away on microtubules.
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Functional Analysis of DRP1 [PDF]
, 2013 (A) The DRP1 locus, with strategy for NEO3 disruption and HA epitope tagging, both via homologous recombination.(B) Southern blot of wild-type (WT) and drp1–1::neo3 lines rescued with DRP1 integrated at the MTT1 locus (DRP1-MTT1) or DRP1 tagged with HA ...
Garry Morgan (12123) +4 more
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