Results 41 to 50 of about 29,949 (269)
The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
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Sequestration puts Drp1 on furlough [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Drp1-x01 (green) localizes to microtubules (red). Strack et al. identify a splice variant of the mitochondrial fission protein Drp1 that can be sequestered away on microtubules.
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Mechanical force induces mitochondrial fission
eLife, 2017 Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive
Sebastian Carsten Johannes Helle +12 more
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The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. [PDF]
, 2018 Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of
Anand, Ruchika +25 more
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Cell Death DiscoveryAbstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves ...
Nan Wang +4 more
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Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy
Journal of Diabetes Research, 2022 Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis.
Ghulam Mohammad, Renu A. Kowluru
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The PINK1/Parkin pathway: a mitochondrial quality control system? [PDF]
, 2009 Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations ...
Pallanck, L.J., Whitworth, A.J.
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Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
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Receptor-mediated Drp1 oligomerization on endoplasmic reticulum [PDF]
Journal of Cell Biology, 2017 Abstract Drpl is a dynamin GTPase important for mitochondrial and peroxisomal division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple factors, including interaction with mitochondrial receptors such as Mff, MiD49, MiD51 and Fis. In addition, both endoplasmic reticulum (ER) and actin filaments play positive
Wei-Ke Ji +5 more
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Heat stress disrupts mitochondrial dynamics and ATF5 expression during porcine oocyte maturation
Journal of Animal Reproduction and BiotechnologyBackground: In mammals, DRP1 is a key regulator of mitochondrial fission during mitochondrial dynamics, whereas ATF5 promotes the mitochondrial unfolded protein response (UPRmt).
Seul-Gi Yang +3 more
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