Results 61 to 70 of about 22,509 (230)

Interaction with CL triggers Drp1 oligomerization. [PDF]

, 2014
A) Left panel: representative far-UV CD spectrum of Drp1 in the absence (−) or presence of LUVs composed of 80PC/20PE or 54PC/20PE/26CL (mol/mol). Right panel: thermal denaturation curves for Drp1 incubated in the absence (−) or presence of 80PC/20PE or ...
Etienne Raemy (600630), Itsasne Bustillo-Zabalbeitia (600628), Gorka Basañez (305683), Sylvie Montessuit (600629), Jean-Claude Martinou (270499), Oihana Terrones (600631)   +5 more
core   +1 more source

Actin filaments as dynamic reservoirs for Drp1 recruitment

Molecular Biology of the Cell, 2016
Drp1 is a dynamin-family GTPase recruited to mitochondria and peroxisomes, where it oligomerizes and drives membrane fission. Regulation of mitochondrial Drp1 recruitment is not fully understood. We previously showed that Drp1 binds actin filaments directly, and actin polymerization is necessary for mitochondrial Drp1 oligomerization in mammals.
Hatch, Anna L., Ji, Wei-Ke, Merrill, Ronald A., Strack, Stefan, Higgs, Henry N.   +4 more
openaire   +2 more sources

Drp1 Phosphorylation Is Indispensable for Steroidogenesis in Leydig Cells [PDF]

Endocrinology, 2019
The initial steps of steroidogenesis occur in the mitochondria. Dynamic changes in the mitochondria are associated with their fission and fusion. Therefore, understanding the cellular and molecular relationships between steroidogenesis and mitochondrial dynamics is important.
Ji-Eun Park, Yoon-Jae Kim, Seung Gee Lee, Ji Young Kim, Jin-Yong Chung, Seon-Yong Jeong, Hyongjong Koh, Jeanho Yun, Hwan Tae Park, Young Hyun Yoo, Jong-Min Kim   +10 more
openaire   +2 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

A mitokondrium hasadásáért felelős Drp1 fehérje rekombináns mutánsainak vizsgálata [PDF]

, 2019
Szakdolgozatom a Drp1 fehérje rekombináns mutánsainak vizsgálatáról szól. Megfigyeltük a mutáns fehérjék eloszlását a humán neuroblasztóma sejtekben. A Drp1 fehérje kulcsszerepet tölt be a mitokondrium osztódásában.
Vadászi, Karina Klára
core  

Drp1 interacts with anionic lipids. [PDF]

, 2014
A) A representative lipid:protein dot-blot showing Drp1 binding. Nitrocellulose membranes spotted with common glycerolipids and sphingolipids present in mammalian cells were incubated with 6 µg/ml Drp1 (Isoform-3).
Etienne Raemy (600630), Itsasne Bustillo-Zabalbeitia (600628), Gorka Basañez (305683), Sylvie Montessuit (600629), Jean-Claude Martinou (270499), Oihana Terrones (600631)   +5 more
core   +1 more source

A dividing matter: Drp1/Dnm1-independent mitophagy [PDF]

Journal of Cell Biology, 2016
Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial. In this issue, Yamashita et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605093) report that mitochondrial fragments start to bud and divide from mitochondrial tubules when in tight association with ...
openaire   +3 more sources

Involvement of SIRT3 downstream targets ANT1, VDAC, CYPD, and Drp1 in a rat model of hepatic encephalopathy: Therapeutic role of thymoquinone [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hepatic encephalopathy (HE) is a brain disorder linked to hyperammonemia from liver injury. Elevated ammonia levels are known to impair mitochondrial function, the primary energy source for cells.
Somayeh Hajipour, Mohammad Amin Dehghani, Alireza Sarkaki, Masoud Mahdavinia, Seyedeh Parisa Navabi   +4 more
doaj   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source