Results 51 to 60 of about 22,509 (230)

DRP1, fission and apoptosis

Cell Death Discovery
Abstract Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves ...
Nan Wang, Xinwai Wang, Beiwu Lan, Yufei Gao, Yuanyuan Cai   +4 more
openaire   +3 more sources

Mechanical force induces mitochondrial fission

eLife, 2017
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive
Sebastian Carsten Johannes Helle, Qian Feng, Mathias J Aebersold, Luca Hirt, Raphael R Grüter, Afshin Vahid, Andrea Sirianni, Serge Mostowy, Jess G Snedeker, Anđela Šarić, Timon Idema, Tomaso Zambelli, Benoît Kornmann   +12 more
doaj   +1 more source

Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy

Journal of Diabetes Research, 2022
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis.
Ghulam Mohammad, Renu A. Kowluru
doaj   +1 more source

CL stimulates Drp1 GTPase activity. [PDF]

, 2014
A) GTPase activity of Drp1 Isoforms 1, 2 and 3, and Mgm1 (0.5 µM each) in solution and in presence of 80PC/20PE, 28PC/20PE/52PS or 54PC/20PE/26CL (mol/mol) (0.5 mM) liposomes. Values are means of three independent experiments ± SEM.
Etienne Raemy (600630), Itsasne Bustillo-Zabalbeitia (600628), Gorka Basañez (305683), Sylvie Montessuit (600629), Jean-Claude Martinou (270499), Oihana Terrones (600631)   +5 more
core   +1 more source

Heat stress disrupts mitochondrial dynamics and ATF5 expression during porcine oocyte maturation

Journal of Animal Reproduction and Biotechnology
Background: In mammals, DRP1 is a key regulator of mitochondrial fission during mitochondrial dynamics, whereas ATF5 promotes the mitochondrial unfolded protein response (UPRmt).
Seul-Gi Yang, Hyo-Jin Park, Hun-Wook Ha, Deog-Bon Koo   +3 more
doaj   +1 more source

The cytoplasmic domain of MiD51 interacts with Drp1 is dependent on Drp1 oligomerization. [PDF]

, 2019
(A) Pull-down assays were performed to test the binding of purified Drp1 or mutants to GST-MiD51133-463 in the presence of different nucleotides. MiD51 and Drp1 or their mutants were mixed evenly before adding to the same amount of resin with the same ...
Yujia Zhai (102840), Jun Ma (9393), Quan Chen (163802), Ming Chen (115604), Kai Zhang (102844), Fei Sun (102854), Xiaoyun Pang (6281864)   +6 more
core   +1 more source

Parkin suppresses Drp1-independent mitochondrial division [PDF]

Biochemical and Biophysical Research Communications, 2016
The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much
Madhuparna, Roy, Kie, Itoh, Miho, Iijima, Hiromi, Sesaki   +3 more
openaire   +2 more sources

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons

Cell Death & Disease, 2018
AbstractDynamin-related protein 1 (DRP1) is a key molecule to regulate mitochondrial fission. DRP1 activity is modulated by phosphorylation and S-nitrosylation on serine and cysteine residues, respectively. However, it is still unexplored whether S-nitrosylation of DRP1 affects its phosphorylation.
Lee, Duk-shin, Kim, Ji-Eun
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source