Animal Cells and Systems, 2021 Excessive alcohol consumption causes the cellular and tissue damage. The toxic metabolites of ethanol are harmful to multiple organ systems, such as the central nervous system, skeletal muscles, and liver, and cause alcohol-induced diseases like cancer ...
Youngsook Choi +6 more
doaj +1 more source
(A) HeLa cells were transfected with control siRNA (siCont) and siRNA for Drp1 (siDrp1) before the transfection with GFP, YFP-Drp1, or YFP-Drp1-S600A and mito-DsRed as described above [PDF]
, 2011 HeLa cells were then either untreated or incubated with 20 mM K for 15 min. (B) Quantitative analysis of exogenous Drp1 foci. Data were obtained from the results from at least five independent experiments for each condition shown in A.
Shun-Ai Li (52667) +9 more
core +1 more source
A Drp1 mitokondriális hasadásért felelős fehérje hatása neuroblasztóma sejtek "in vitro" neurális differenciációjára - globális transzkripciós változások "in silico" analízise. [PDF]
, 2023 A mitokondriumok dinamikus organellumok, amelyek folyamatos fúzión és hasadáson mennek keresztül. Az olyan neurodegeneratív betegségekre, mint például a Huntington kór gyakran jellemző a mitokondriális dinamika felborulása.
Zöld, Mariann Emese
core
Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system
Molecular Brain, 2020 Objectives Drp1 is widely expressed in the mouse central nervous system and plays a role in inducing the mitochondrial fission process. Many diseases are associated with Drp1 and mitochondria.
Ting-Ting Luo +8 more
doaj +1 more source
Exploring the impact of Serine39 (S39A) mutation of the Dynamin-related protein (Drp1) on mitochondrial dynamics of human neuroblastoma cells [PDF]
, 2022 Drp1 function and mechanism in mammalian cells have been extensively studied, and multiple attempts were carried out for a better understanding of the enzymatic activity of the protein and its mechanism in mitochondrial fission.
Alkhatibe, Mahmoud
core
The phosphorylation state of Drp1 determines cell fate [PDF]
The EMBO Reports, 2007 Recent research has opened new avenues for the evaluation of mitochondrial function; for example, mitochondria are no longer perceived as thread‐like static entities within the cytosol, but instead are viewed as highly dynamic organelles that can change in shape and size, and are transported to strategic locations within the cell.
Arezu, Jahani-Asl, Ruth S, Slack
openaire +2 more sources
SENP3 Promotes an Mff-Primed Bcl-xL-Drp1 Interaction Involved in Cell Death Following Ischemia
Frontiers in Cell and Developmental Biology, 2021 Dysregulation of the mitochondrial fission machinery has been linked to cell death following ischemia. Fission is largely dependent on recruitment of Dynamin-related protein 1 (Drp1) to the receptor Mitochondrial fission factor (Mff) located on the ...
Chun Guo +7 more
doaj +1 more source
Metabolic consequences of neuronal mitochondrial fission ablation [PDF]
, 2016 Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core +1 more source
Di-san junyi daxue xuebao, 2020 Objective To explore the mechanism by which luteolin alleviates oxidative stress in mice with cerebral ischemia-reperfusion. Methods We screened the antioxidants with potential therapeutic effect on cerebral ischemia-reperfusion injury using CMap dataset
ZENG Xue +4 more
doaj +1 more source
Cells, 2020 Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival.
Yujia Liu +2 more
doaj +1 more source