Results 31 to 40 of about 19,581 (227)

Mechanical force induces mitochondrial fission

eLife, 2017
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive
Sebastian Carsten Johannes Helle, Qian Feng, Mathias J Aebersold, Luca Hirt, Raphael R Grüter, Afshin Vahid, Andrea Sirianni, Serge Mostowy, Jess G Snedeker, Anđela Šarić, Timon Idema, Tomaso Zambelli, Benoît Kornmann   +12 more
doaj   +1 more source

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum [PDF]

Journal of Cell Biology, 2017
Abstract Drpl is a dynamin GTPase important for mitochondrial and peroxisomal division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple factors, including interaction with mitochondrial receptors such as Mff, MiD49, MiD51 and Fis. In addition, both endoplasmic reticulum (ER) and actin filaments play positive
Wei-Ke Ji, Rajarshi Chakrabarti, Xintao Fan, Lori Schoenfeld, Stefan Strack, Henry N. Higgs   +5 more
openaire   +2 more sources

Heat stress disrupts mitochondrial dynamics and ATF5 expression during porcine oocyte maturation

Journal of Animal Reproduction and Biotechnology
Background: In mammals, DRP1 is a key regulator of mitochondrial fission during mitochondrial dynamics, whereas ATF5 promotes the mitochondrial unfolded protein response (UPRmt).
Seul-Gi Yang, Hyo-Jin Park, Hun-Wook Ha, Deog-Bon Koo   +3 more
doaj   +1 more source

Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy

Journal of Diabetes Research, 2022
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis.
Ghulam Mohammad, Renu A. Kowluru
doaj   +1 more source

The Structure of the Drp1 Lattice on Membrane

Journal of Molecular Biology
ABSTRACT Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial fission mechanisms. Here we present a cryo-electron microscopy structure of
Ruizhi Peng, Kristy Rochon, Anelise N. Hutson, Scott M. Stagg, Jason A. Mears   +4 more
openaire   +3 more sources

Parkin suppresses Drp1-independent mitochondrial division [PDF]

Biochemical and Biophysical Research Communications, 2016
The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much
Madhuparna, Roy, Kie, Itoh, Miho, Iijima, Hiromi, Sesaki   +3 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons

Cell Death & Disease, 2018
AbstractDynamin-related protein 1 (DRP1) is a key molecule to regulate mitochondrial fission. DRP1 activity is modulated by phosphorylation and S-nitrosylation on serine and cysteine residues, respectively. However, it is still unexplored whether S-nitrosylation of DRP1 affects its phosphorylation.
Lee, Duk-shin, Kim, Ji-Eun
openaire   +2 more sources

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria [PDF]

Proceedings of the National Academy of Sciences, 2008
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance between fusion and fission processes. Excessive fragmentation can be caused by inhibition of the fusion machinery and is a common consequence of dysfunction of the organelle.
CEREGHETTI GM, STANGHERLIN A, DE BRITO OM, CHANG CR, BLACKSTONE C, BERNARDI, PAOLO, SCORRANO, LUCA   +6 more
openaire   +4 more sources

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source