Results 11 to 20 of about 29,949 (269)
Structural basis of mitochondrial receptor binding and constriction by DRP1. [PDF]
Nature, 2018 Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa
Agard, David A +6 more
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MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff [PDF]
Scientific Reports, 2017 Mitochondrial dynamics is a fundamental cellular process and recruitment of Drp1 to mitochondria is an essential step in mitochondrial fission. Mff and MIEF1/2 (MiD51/49) serve as key receptors for recruitment of Drp1 to mitochondria in mammals. However,
Rong Yu +6 more
doaj +3 more sources
A novel small molecule inhibitor of human Drp1
Scientific Reports, 2022 Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes.
Ayeshah A. Rosdah +12 more
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New interfaces on MiD51 for Drp1 recruitment and regulation.
PLoS ONE, 2019 Mitochondrial fission is facilitated by dynamin-related protein Drp1 and a variety of its receptors. However, the molecular mechanism of how Drp1 is recruited to the mitochondrial surface by receptors MiD49 and MiD51 remains elusive. Here, we showed that
Jun Ma +6 more
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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes [PDF]
Cell Reports, 2021 During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the induction of pluripotency, but its molecular mechanisms remain poorly defined.
Young Cha +8 more
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Drp1 phosphorylation and mitochondrial regulation [PDF]
EMBO reports, 2007 A paper by Cribbs & Strack (2007) in a recent issue of EMBO Reports , as well as an earlier study published by our group (Chang & Blackstone, 2007), emphasize the important roles of protein phosphorylation by cAMP‐dependent protein kinase (PKA) in the regulation of the dynamin‐related protein 1 (Drp1) GTPase and mitochondrial fission.
Chuang-Rung, Chang, Craig, Blackstone
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SUMO wrestling with Drp1 at mitochondria [PDF]
The EMBO Journal, 2013 EMBO J 32 11: 1514–1528; March222013; 10.1038/emboj.2013.65 Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia.
Caroline A, Anderson, Craig, Blackstone
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Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Biology Open, 2020 Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte +5 more
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Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells
Cells, 2020 Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1,
Liza Douiev +3 more
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Viruses, 2020 Mitochondrial dynamics is essential for the maintenance of cell homeostasis. Previous studies have shown that porcine circovirus 2 (PCV2) infection decreases the mitochondrial membrane potential and causes the elevation of reactive oxygen species (ROS ...
Yikai Zhang +3 more
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