Results 11 to 20 of about 22,509 (230)
Mechanisms of Drp1 Recruitment to Mitochondria [PDF]
, 2017 Dynamin-related protein 1 (Drp1) is a GTPase of the dynamin superfamily that catalyzes mitochondrial fission in the cell. Cytosolic Drp1 is recruited to mitochondria by receptors anchored to the outer mitochondrial membrane.
Liu, Raymond
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Receptor-mediated Drp1 oligomerization on endoplasmic reticulum [PDF]
Journal of Cell Biology, 2017 Drp1 is a dynamin guanosine triphosphatase important for mitochondrial and peroxisomal division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple factors, including interaction with mitochondrial receptors such as Mff, MiD49 ...
Stefan Strack +5 more
core +6 more sources
The Structure of the Drp1 Lattice on Membrane [PDF]
Journal of Molecular BiologyMitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the mitochondrial ...
Hutson, Anelise N. +2 more
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Drp1 ablation in the adult mouse forebrain [PDF]
, 2014 Due to their high energy demand, their highly polarized nature and the sheer length of their processes, neurons - more than any other cell type - depend on a well-balanced dynamic mitochondrial network.
Oettinghaus, Bjorn
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Functional characterization of human DRP1 [PDF]
, 2012 Das Ziel dieser Studie war die Charakterisierung des Proteins DRP1 (dynamin related protein 1), der Hauptfaktor bei der mitochondrialen Teilung, auf biochemischer und biophysikalischer Ebene.
Mayr, Sandra
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Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice [PDF]
Redox BiologyBackground: Depression is a common psychiatric disorder characterized by heightened stress exposure and disruptions in neuronal signaling. Growing evidence suggests that mitochondrial dysfunction contributes to its pathophysiology.
Jia-Rui Zhang +11 more
doaj +2 more sources
SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes [PDF]
Cell Reports, 2021 During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the induction of pluripotency, but its molecular mechanisms remain poorly defined.
Young Cha +8 more
openaire +2 more sources
Regulation of mitochondrial morphology and metabolism by Jak-STAT pathway
Journal of Animal Reproduction and Biotechnology, 2021 Jak-STAT pathway is required for embryogenesis, female gametogenesis, cytokine-mediated neuroprotection, diabetes, obesity, cancer, stem cell, and various tissues.
Kun Do Rhee
doaj +1 more source
International Journal of Hyperthermia, 2022 Objective The incidence rate of heat stroke (HS) has increased, with high morbidity and mortality rates, in recent years. Previous studies have suggested that vascular endothelial cell injury is one of the main pathological features of HS.
Wei Huang +6 more
doaj +1 more source
Drp1 phosphorylation and mitochondrial regulation [PDF]
The EMBO Reports, 2007 A paper by Cribbs & Strack (2007) in a recent issue of EMBO Reports , as well as an earlier study published by our group (Chang & Blackstone, 2007), emphasize the important roles of protein phosphorylation by cAMP‐dependent protein kinase (PKA) in the regulation of the dynamin‐related protein 1 (Drp1) GTPase and mitochondrial fission.
Chuang-Rung, Chang, Craig, Blackstone
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