Results 11 to 20 of about 49,263 (303)

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. [PDF]

PLoS ONE, 2008
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown.
Philippe A Parone, Sandrine Da Cruz, Daniel Tondera, Yves Mattenberger, Dominic I James, Pierre Maechler, François Barja, Jean-Claude Martinou   +7 more
doaj   +2 more sources

Mitochondrial fission during mitophagy requires both inner and outer mitofissins [PDF]

EMBO Reports
Mitophagy maintains mitochondrial homeostasis through the selective degradation of damaged or excess mitochondria. Recently, we identified mitofissin/Atg44, a mitochondrial intermembrane space-resident fission factor, which directly acts on lipid ...
Kentaro Furukawa, Tatsuro Maruyama, Yuji Sakai, Shun-ichi Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Nobuo N Noda, Tomotake Kanki   +7 more
doaj   +2 more sources

Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients. [PDF]

J Inflamm Res
The glomerular injury is associated with different pathogeneses, and podocyte damage is common in various ISN/RPS class lupus nephritis (LN). In podocyte, mitochondrial morphological changes are observed in lupus nephritis (LN) in our previous study. This study aimed to explore mitochondrial fission proteins expression in podocytes using bioinformatics
Wei Q, Wu X, Chen Z, Lin H, Xiong L, Wang N.   +5 more
europepmc   +4 more sources

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Redox Biology, 2018
Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury.
Qinhua Jin, Ruibing Li, Nan Hu, Ting Xin, Pingjun Zhu, Shunying Hu, Sai Ma, Hong Zhu, Jun Ren, Hao Zhou   +9 more
doaj   +3 more sources

Mitochondrial Fusion and Fission in Mammals [PDF]

Annual Review of Cell and Developmental Biology, 2006
Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
Chan, David C.
openaire   +4 more sources

Novel roles for actin in mitochondrial fission [PDF]

Journal of Cell Science, 2014
Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial fission has received particular attention, owing to links with several neurodegenerative diseases.
Anna L, Hatch, Pinar S, Gurel, Henry N, Higgs   +2 more
openaire   +4 more sources

Bioenergetic role of mitochondrial fusion and fission

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the morphology of the mitochondrial compartment to the metabolic needs of the cell. Mitochondrial fusion is particularly important in respiratory active cells. It allows the spreading of metabolites, enzymes, and mitochondrial gene products throughout the entire ...
Westermann, Benedikt
openaire   +3 more sources

RETRACTED: Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation

Frontiers in Cell and Developmental Biology, 2021
Although mitochondrial fission has been reported to increase proliferative capacity and collagen production, it can also contribute to mitochondrial impairment, which is detrimental to cell survival.
Qing-Yuan Gao, Qing-Yuan Gao, Hai-Feng Zhang, Hai-Feng Zhang, Jun Tao, Zhi-Teng Chen, Zhi-Teng Chen, Chi-Yu Liu, Chi-Yu Liu, Wen-Hao Liu, Wen-Hao Liu, Mao-Xiong Wu, Mao-Xiong Wu, Wen-Yao Yin, Wen-Yao Yin, Guang-Hao Gao, Guang-Hao Gao, Yong Xie, Yong Xie, Ying Yang, Ying Yang, Pin-Ming Liu, Pin-Ming Liu, Jing-Feng Wang, Jing-Feng Wang, Yang-Xin Chen, Yang-Xin Chen   +26 more
doaj   +1 more source

Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation

Cell Death and Disease, 2022
Previous studies have demonstrated dysregulated mitochondrial dynamics in fibrotic livers and hepatocytes. Little is currently known about how mitochondrial dynamics are involved, nor is it clear how mitochondrial dynamics participate in hepatic stellate
Yanni Zhou, Dan Long, Ying Zhao, Shengfu Li, Yan Liang, Lin Wan, Jingyao Zhang, Fulai Xue, Li Feng   +8 more
doaj   +1 more source

Mitochondrial fission and fusion [PDF]

Essays in Biochemistry, 2010
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
openaire   +2 more sources