Results 21 to 30 of about 43,432 (263)

Mitochondrial morphological features are associated with fission and fusion events. [PDF]

PLoS ONE, 2014
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate, Jeffrey A Drocco, Katie R Martin, William S Hlavacek, Jeffrey P MacKeigan   +4 more
doaj   +1 more source

Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways

BMC Cell Biology, 2018
Background Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis.
Sayilaxi Jieensinue, Hong Zhu, Guangcheng Li, Keli Dong, Meiting Liang, Yayue Li   +5 more
doaj   +1 more source

Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through an ROS-dependent mechanism

iScience, 2023
Summary: Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells.
Brock A. Humphries, Anne Zhang, Johanna M. Buschhaus, Avinash Bevoor, Alex Farfel, Shrila Rajendran, Alyssa C. Cutter, Gary D. Luker   +7 more
doaj   +1 more source

miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

PLoS Genetics, 2010
miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis.
Jincheng Li, Stefan Donath, Yanrui Li, Danian Qin, Bellur S Prabhakar, Peifeng Li   +5 more
doaj   +1 more source

The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases

Cells, 2023
Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium
Pierce Colpman, Asish Dasgupta, Stephen L. Archer   +2 more
doaj   +1 more source

Mitochondrial Fission in Human Diseases [PDF]

, 2016
Mitochondria are an essential component of multicellular life - from primitive organisms, to highly complex entities like mammals. The importance of mitochondria is underlined by their plethora of well-characterized essential functions such as energy production through oxidative phosphorylation (OX-PHOS), calcium and reactive oxygen species (ROS ...
Madhavika N, Serasinghe, Jerry E, Chipuk
openaire   +2 more sources

Mitochondrial membrane tension governs fission [PDF]

Cell Reports, 2018
Abstract During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide, or reverse upon disassembly of the machinery. However, a role for membrane tension in mitochondrial fission, although speculated,
Mahecic, Dora, Carlini, Lina, Kleele, Tatjana, Colom Diego, Adai, Goujon, Antoine, Matile, Stefan, Roux, Aurélien, Manley, Suliana   +7 more
openaire   +6 more sources

Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity

FEBS Open Bio, 2021
Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan, Jingjiong Chen, Xuhua Ge, Jiangshan Deng, Xiaofeng Xu, Yuwu Zhao, Hongmei Wang   +6 more
doaj   +1 more source

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

Frontiers in Pharmacology, 2018
Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis.
Jia Qi, Jia Qi, Feng Wang, Ping Yang, Xuelian Wang, Renjie Xu, Jihui Chen, Yanggang Yuan, Zhaoyang Lu, Zhaoyang Lu, Junli Duan   +10 more
doaj   +1 more source

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

Journal of Experimental & Clinical Cancer Research, 2020
Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis ...
Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, liwen Shen, Jingshan Shi, Ning Gao   +8 more
doaj   +1 more source