Results 21 to 30 of about 1,174,031 (334)
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]
PLoS Computational Biology, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge +3 more
doaj +3 more sources
Frontiers in Endocrinology, 2021 Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for mitochondrial division or fission and subsequently determined to mediate human mitochondrial and peroxisomal fission.
Blake Hill, Michael E Widlansky
exaly +2 more sources
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Molecular Cell, 2021 Mitochondrial dynamics regulated by mitochondrial fusion and fission essentially maintain mitochondrial functions, whose alterations underline various human diseases. Here we show that inositol is a critical metabolite directly restricting AMPK-dependent
Bo-Syong Pan, Hong-Yu Li, Zhong-Zhu Chen
exaly +2 more sources
Cells, 2023 Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium
Pierce Colpman +2 more
doaj +2 more sources
Mitochondrial membrane tension governs fission [PDF]
Cell Reports, 2018 Abstract During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide, or reverse upon disassembly of the machinery. However, a role for membrane tension in mitochondrial fission, although speculated,
Mahecic, Dora +7 more
core +8 more sources
Redox Biology, 2018 Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury.
Qinhua Jin +9 more
doaj +3 more sources
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. [PDF]
PLoS ONE, 2008 Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown.
Philippe A Parone +7 more
doaj +2 more sources
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation [PDF]
Cell Death and DiseaseMitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood.
Daniel Lagos +8 more
doaj +2 more sources
Mechanisms of Ageing and Development, 2020 The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related ...
Riekelt H Houtkooper +2 more
exaly +2 more sources
The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease
International Journal of Molecular Sciences, 2022 Mitochondria have many forms and can change their shape through fusion and fission of the outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer membrane proteins, such as mitochondrial fission protein 1 (FIS1), mitochondrial ...
Lingyu Qin, Shuhua Xi
semanticscholar +2 more sources