Results 31 to 40 of about 77,225 (305)
FEBS Open Bio, 2021 Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan +6 more
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Mitochondrial Fission in Human Diseases [PDF]
, 2016 Mitochondria are an essential component of multicellular life - from primitive organisms, to highly complex entities like mammals. The importance of mitochondria is underlined by their plethora of well-characterized essential functions such as energy production through oxidative phosphorylation (OX-PHOS), calcium and reactive oxygen species (ROS ...
Madhavika N, Serasinghe, Jerry E, Chipuk
openaire +2 more sources
Emerging functions of mammalian mitochondrial fusion and fission [PDF]
, 2005 Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
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Atypical mitochondrial fission upon bacterial infection [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Mitochondria are dynamic organelles that constantly fuse and fragment while acting as central hubs of energy production, apoptosis regulation, and Ca ++ signaling, therefore emerging as potential targets of pathogens.
Stavru, Fabrizia +4 more
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Frontiers in Pharmacology, 2018 Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis.
Jia Qi +10 more
doaj +1 more source
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [PDF]
, 2005 The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria.
Chan, David C. +2 more
core +3 more sources
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. [PDF]
PLoS ONE, 2008 Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown.
Philippe A Parone +7 more
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Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes [PDF]
, 2016 The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions.
Nakatsuka, Atsuko, Wada, Jun
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Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological ...
Shafiul Alam +9 more
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Journal of Experimental & Clinical Cancer Research, 2020 Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis ...
Jinjiao Hu +8 more
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