Results 31 to 40 of about 1,174,031 (334)

Mitochondrial fission during mitophagy requires both inner and outer mitofissins [PDF]

EMBO Reports
Mitophagy maintains mitochondrial homeostasis through the selective degradation of damaged or excess mitochondria. Recently, we identified mitofissin/Atg44, a mitochondrial intermembrane space-resident fission factor, which directly acts on lipid ...
Kentaro Furukawa, Tatsuro Maruyama, Yuji Sakai, Shun-ichi Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Nobuo N Noda, Tomotake Kanki   +7 more
doaj   +2 more sources

Novel roles for actin in mitochondrial fission [PDF]

Journal of Cell Science, 2014
Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial fission has received particular attention, owing to links with several neurodegenerative diseases.
Anna L, Hatch, Pinar S, Gurel, Henry N, Higgs   +2 more
openaire   +4 more sources

Distinct fission signatures predict mitochondrial degradation or biogenesis

Nature, 2021
Comment in Revolutionary view of two ways to split a mitochondrion. Chakrabarti R, Higgs HN. Nature. 2021 May;593(7859):346-347. doi: 10.1038/d41586-021-01173-x.
Tatjana Kleele, Timo Rey, J. Winter, S. Zaganelli, Dora Mahecic, Hélène Perreten Lambert, F. Ruberto, M. Nemir, T. Wai, T. Pedrazzini, S. Manley   +10 more
semanticscholar   +2 more sources

RETRACTED: Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation

Frontiers in Cell and Developmental Biology, 2021
Although mitochondrial fission has been reported to increase proliferative capacity and collagen production, it can also contribute to mitochondrial impairment, which is detrimental to cell survival.
Qing-Yuan Gao, Qing-Yuan Gao, Hai-Feng Zhang, Hai-Feng Zhang, Jun Tao, Zhi-Teng Chen, Zhi-Teng Chen, Chi-Yu Liu, Chi-Yu Liu, Wen-Hao Liu, Wen-Hao Liu, Mao-Xiong Wu, Mao-Xiong Wu, Wen-Yao Yin, Wen-Yao Yin, Guang-Hao Gao, Guang-Hao Gao, Yong Xie, Yong Xie, Ying Yang, Ying Yang, Pin-Ming Liu, Pin-Ming Liu, Jing-Feng Wang, Jing-Feng Wang, Yang-Xin Chen, Yang-Xin Chen   +26 more
doaj   +1 more source

Mitochondrial fission and fusion [PDF]

Essays in Biochemistry, 2010
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
openaire   +2 more sources

The role of mitochondrial fission in cardiovascular health and disease

Nature Reviews Cardiology, 2022
Mitochondria are organelles involved in the regulation of various important cellular processes, ranging from ATP generation to immune activation. A healthy mitochondrial network is essential for cardiovascular function and adaptation to pathological ...
Justin M. Quiles, Åsa B. Gustafsson
semanticscholar   +1 more source

Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Journal of Translational Medicine, 2023
Background Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target
Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, M. Zheng, Qing-Wei Chen   +4 more
semanticscholar   +1 more source

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.

PLoS Genetics, 2020
Balanced mitochondrial fission and fusion play an important role in shaping and distributing mitochondria, as well as contributing to mitochondrial homeostasis and adaptation to stress.
Ana Terriente-Felix, Emma L Wilson, Alexander J Whitworth   +2 more
doaj   +1 more source

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Nature Communications, 2023
Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi   +11 more
doaj   +1 more source

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance

Nature Cell Biology, 2022
Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether and how the mechanical properties of the local tissue influence their response to treatment remains unclear.
P. Romani, Nunzia Nirchio, Mattia Arboit, V. Barbieri, A. Tosi, F. Michielin, Soichi Shibuya, Thomas Benoist, Danchen Wu, Charles C. T. Hindmarch, M. Giomo, A. Urciuolo, Flavia Giamogante, A. Roveri, P. Chakravarty, Marco Montagner, Tito Calì, N. Elvassore, Stephen L. Archer, P. de Coppi, A. Rosato, G. Martello, S. Dupont   +22 more
semanticscholar   +1 more source