Results 31 to 40 of about 43,432 (263)
Quantifying Regulated Mitochondrial Fission in Macrophages
, 2022 Mitochondria have co-evolved with eukaryotic cells for more than a billion years, becoming an important cog in their machinery. They are best known for being tasked with energy generation through the production of adenosine triphosphate, but they also have roles in several other cellular processes, for example, immune and inflammatory responses ...
Afroz, Syeda Farhana +3 more
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Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. [PDF]
PLoS ONE, 2008 Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown.
Philippe A Parone +7 more
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Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological ...
Shafiul Alam +9 more
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Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
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Acta Pharmaceutica Sinica B, 2017 Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of ...
Jing Jin +10 more
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The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. [PDF]
PLoS ONE, 2012 Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1.
Qian Guo +4 more
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Mitochondrial fission/fusion and cardiomyopathy [PDF]
Current Opinion in Genetics & Development, 2016 Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
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Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission [PDF]
Current Biology, 2004 Mitochondrial fission requires the evolutionarily conserved dynamin related protein (DRP1), which is recruited from the cytosol to the mitochondrial outer membrane to coordinate membrane scission. Currently, the mechanism of recruitment and assembly of DRP1 on the mitochondria is unclear.
Harder, Zdena +2 more
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Neurobiology of Disease, 2011 Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold +3 more
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Plant mitochondrial fission and fusion
Plant Biotechnology, 2005 Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Arimura, Shin-ichi, Tsutsumi, Nobuhiro
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