Results 51 to 60 of about 49,263 (303)

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Jan-Willem Taanman, Shamima Rahman, Laura D. Osellame, Gilmour, Kimberley, Glenn Anderson, Jacques, Thomas S, Sophie Hambleton, Cale, Catherine, Osellame, Laura, Plagnol, Vincent, Chalasani, A, Annapurna Chalasani, Gilmour, KC, Hambleton, Sophie, Wedatilake, Yehani, Gilmour, Kimberley C, Duchen, Michael R, Osellame, LD, Taanman, Jan-Willem, Jacques, S, Vincent Plagnol, Plagnol, V, Rahman, S, Yehani Wedatilake, Michael R. Duchen, Shahni, Rojeen, Qasim, Waseem, Thomas S. Jacques, Catherine M. Cale, Duchen, Michael, Cale, Catherine M, Waseem Qasim, Anderson, Glenn, Wadatilake, Y, Cale, CM, Rahman, Shamima, Osellame, Laura D, Taanman, JW, Chan, E, Jacques, Thomas, Anderson, G, Rojeen Shahni, Chalasani, Annapurna, Kimberly C. Gilmour, Qasim, W, Emma Chan, Hambleton, S, Duchen, MR, Shahni, R, Chan, Emma   +49 more
core   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

Neurobiology of Disease, 2011
Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold, Steven J. Cassady, Victor S. VanLaar, Sarah B. Berman   +3 more
doaj   +1 more source

The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. [PDF]

PLoS ONE, 2012
Mitochondrial fission in eukaryotes is mediated by protein complexes that encircle and divide mitochondrial tubules. In budding yeast, fission requires the membrane-anchored protein Fis1 and the dynamin-related GTPase Dnm1.
Qian Guo, Sajjan Koirala, Edward M Perkins, J Michael McCaffery, Janet M Shaw   +4 more
doaj   +1 more source

Mitochondrial fission/fusion and cardiomyopathy [PDF]

Current Opinion in Genetics & Development, 2016
Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
openaire   +2 more sources

Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission [PDF]

Current Biology, 2004
Mitochondrial fission requires the evolutionarily conserved dynamin related protein (DRP1), which is recruited from the cytosol to the mitochondrial outer membrane to coordinate membrane scission. Currently, the mechanism of recruitment and assembly of DRP1 on the mitochondria is unclear.
Harder, Zdena, Zunino, Rodolfo, McBride, Heidi   +2 more
openaire   +2 more sources

Plant mitochondrial fission and fusion

Plant Biotechnology, 2005
Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Arimura, Shin-ichi, Tsutsumi, Nobuhiro
openaire   +3 more sources

Mitochondrial Membrane Remodeling [PDF]

, 2022
Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders.
Yang, Cheng, Wu, Qiong, Zhou, Zuping, Guo, Ziqi, Yang, Ziyun, Pu, Shiming, Wang, Liang, Zhao, Hongxia   +7 more
core   +1 more source

Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine

Acta Pharmaceutica Sinica B, 2017
Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of ...
Jing Jin, Xin Shen, Yu Tai, Shanliang Li, Mingyu Liu, Changlin Zhen, Xiuchen Xuan, Xiyue Zhang, Nan Hu, Xinzi Zhang, Deli Dong   +10 more
doaj   +1 more source

Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparum

mSphere, 2020
Malaria remains a huge global health burden, and control of this disease has run into a severe bottleneck. To defeat malaria and reach the goal of eradication, a deep understanding of the parasite biology is urgently needed.
Mulaka Maruthi, Liqin Ling, Jing Zhou, Hangjun Ke   +3 more
doaj   +1 more source