Results 71 to 80 of about 49,263 (303)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Participation of mitochondrial fission during mitophagy [PDF]
Cell Cycle, 2013 Due to the key role of mitochondria in cell metabolism, the quantity and quality of this organelle must be maintained properly, which is achieved by constitutive mitochondrial fusion and fission as well as biogenesis and degradation. A fission complex controls mitochondrial division, whereas degradation occurs primarily through autophagy.
Mao, Kai, Klionsky, Daniel J
openaire +2 more sources
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Ecotoxicology and Environmental Safety, 2022 Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong +11 more
doaj +1 more source
Distinct molecular signatures of fission predict mitochondrial degradation or proliferation
, 2021 Posté sur BioRxiv le 11 novembre 2020Mitochondrial fission is a highly regulated process which, when disrupted, can alter metabolism, proliferation and apoptosis 1–3 . The downstream effects have implications for many diseases, from neurodegeneration 4–6
Wai, Timothy +11 more
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Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells
, 2010 Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V. +23 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]
, 2014 Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
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Distinct fission signatures predict mitochondrial degradation or biogenesis
, 2021 Comment in Revolutionary view of two ways to split a mitochondrion. Chakrabarti R, Higgs HN. Nature. 2021 May;593(7859):346-347. doi: 10.1038/d41586-021-01173-x.
Ruberto, Francesco, Paolo +12 more
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