Results 61 to 70 of about 77,225 (305)
PLoS Biology, 2023 Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient fusion leads to mitochondrial fragmentation, causing mitochondrial dysfunction and physiological disorders.
Jiajia He +17 more
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Plant mitochondrial fission and fusion
Plant Biotechnology, 2005 Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Shin-Ichi, Arimura, Nobuhiro, Tsutsumi
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Mitochondrial fission/fusion dynamics and apoptosis [PDF]
Mitochondrion, 2010 Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks are dramatically reorganised from long filamentous interconnected tubules into small punctate spheres.
MARTIN, SEAMUS, SHERIDAN, CLARE
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BMC Biology, 2021 Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu +6 more
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Geometric instability catalyzes mitochondrial fission
Molecular Biology of the Cell, 2019 The mitochondrial membrane undergoes extreme remodeling during fission. While a few membrane-squeezing proteins are recognized as the key drivers of fission, there is a growing body of evidence that strongly suggests that conical lipids play a critical role in regulating mitochondrial morphology and fission.
Irajizad, Ehsan +2 more
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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]
, 2017 The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías +12 more
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The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. [PDF]
, 2018 Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of
Anand, Ruchika +25 more
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Frontiers in Pharmacology, 2021 Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). Mitochondrial morphology is dynamic and precisely regulated by mitochondrial fission and fusion machinery.
Hanyu Yang +11 more
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Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. [PDF]
, 2005 Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells.
Ascione, Barbara +7 more
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Mechano-induced mitochondrial fission [PDF]
Science, 2017 Cell Biology The inside of a cell is crowded with lots of different organelles that need to be accommodated in a constrained environment. What happens when different organelles bump into one another? Dynamic reticular organelles, such as the endoplasmic reticulum and mitochondria, are continually being remodeled.
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