Results 61 to 70 of about 43,432 (263)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway activation

Ecotoxicology and Environmental Safety, 2022
Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu   +11 more
doaj   +1 more source

Quantification of Mitochondrial Dynamics in Fission Yeast [PDF]

BIO-PROTOCOL, 2019
Mitochondria are double-membraned organelles responsible for several functions in the cell including energy production, calcium signaling, and cellular metabolism. An equilibrium between fission and fusion events of mitochondria is required for their proper functioning.
Leeba Chacko, Vaishnavi Ananthanarayanan
openaire   +3 more sources

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Antiviral Effects of Menthol on Coxsackievirus B

Viruses, 2020
Coxsackievirus B (CVB) is a common human enterovirus that causes systemic infection but specifically replicates to high titers in the pancreas. It was reported that certain viruses induce mitochondrial fission to support infection. We documented that CVB
David J.R. Taylor, Syed M. Hamid, Allen M. Andres, Hannaneh Saadaeijahromi, Honit Piplani, Juliana F. Germano, Yang Song, Savannah Sawaged, Ralph Feuer, Stephen J. Pandol, Jon Sin   +10 more
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

DRP1, fission and apoptosis

Cell Death Discovery
Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy.
Nan Wang, Xinwai Wang, Beiwu Lan, Yufei Gao, Yuanyuan Cai   +4 more
doaj   +1 more source

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Redox Biology, 2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Antonio Hernandez-Mijares, Milagros Rocha, Victor M. Victor   +5 more
doaj   +1 more source

Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]

PLoS Computational Biology, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge, Andreas S Reichert, Michael Meyer-Hermann, Heinz D Osiewacz   +3 more
doaj   +1 more source

Recent advances into the understanding of mitochondrial fission

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
Mitochondria exist as a highly dynamic tubular network, and their morphology is governed by the delicate balance between frequent fusion and fission events, as well as by interactions with the cytoskeleton. Alterations in mitochondrial morphology are associated with changes in metabolism, cell development and cell death, whilst several human ...
Elgass, Kirstin, Pakay, Julian, Ryan, Michael T., Palmer, Catherine S.   +3 more
openaire   +2 more sources