Results 61 to 70 of about 49,263 (303)

TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]

PLoS ONE, 2012
Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura, Yoshihisa Koyama, Shinsuke Matsuzaki, Kohei Yamada, Tsuyoshi Hattori, Shingo Miyata, Kana Takemoto, Masaya Tohyama, Taiichi Katayama   +8 more
doaj   +1 more source

Emergence of the mitochondrial reticulum from fission and fusion dynamics

, 2012
Mitochondria form a dynamic tubular reticulum within eukaryotic cells. Currently, quantitative understanding of its morphological characteristics is largely absent, despite major progress in deciphering the molecular fission and fusion machineries ...
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Sukhorukov, Valerii M., Daniel Dikov (124160), Valerii M. Sukhorukov (124158), Reichert, Andreas, Valerii M. Sukhorukov, Dikov, Daniel, Andreas S. Reichert, Meyer-Hermann, Michael (Prof. Dr.), Valerii M Sukhorukov, Daniel Dikov, Andreas S Reichert   +13 more
core   +1 more source

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1

Frontiers in Pharmacology, 2021
Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). Mitochondrial morphology is dynamic and precisely regulated by mitochondrial fission and fusion machinery.
Hanyu Yang, Lu Wang, Caixia Zang, Xu Yang, Xiuqi Bao, Junmei Shang, Zihong Zhang, Hui Liu, Cheng Ju, Fangyuan Li, Fangyu Yuan, Dan Zhang   +11 more
doaj   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs   +23 more
core   +1 more source

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission.

PLoS Biology, 2023
Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient fusion leads to mitochondrial fragmentation, causing mitochondrial dysfunction and physiological disorders.
Jiajia He, Ke Liu, Yifan Wu, Chenhui Zhao, Shuaijie Yan, Jia-Hui Chen, Lizhu Hu, Dongmei Wang, Fan Zheng, Wenfan Wei, Chao Xu, Chengdong Huang, Xing Liu, Xuebiao Yao, Lijun Ding, Zhiyou Fang, Ai-Hui Tang, Chuanhai Fu   +17 more
doaj   +1 more source

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries

BMC Biology, 2021
Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

Mitochondrial fission and apoptosis: An ongoing trial

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
Apoptosis is a form of programmed cell death that is essential for the development and tissue homeostasis in all metazoan animals. Mitochondria play a critical role during apoptosis, since the release of pro-apoptogenic proteins from the organelle is a pivotal event in cell death triggered by many cytotoxic stimuli.
Parone, Philippe, Martinou, Jean-Claude
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

Neurobiology of Disease, 2009
Mutations in the GDAP1 gene lead to recessively or dominantly inherited peripheral neuropathies (Charcot–Marie–Tooth disease; CMT). Here, we demonstrate that GDAP1 is a mitochondrial fission factor whose activity is dependent on the fission factors Drp1 ...
Axel Niemann, Konstanze Marion Wagner, Marcel Ruegg, Ueli Suter   +3 more
doaj   +1 more source