Results 91 to 100 of about 77,225 (305)

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]

PLoS Computational Biology, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge, Andreas S Reichert, Michael Meyer-Hermann, Heinz D Osiewacz   +3 more
doaj   +1 more source

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy [PDF]

, 2015
Defects in mitochondrial fusion or fission are associated with many pathologies, raising the hope that pharmacological manipulation of mitochondrial dynamics may have therapeutic benefit.
Agah, Alexander, Brand, Cassidy-Stone, Chen, Chen, Chen, Chen, Chen, Clary Clish, David C. Chan, Delettre, Dorn, Friedman, Gandre-Babbe, Harvey, Hayashi, Hsiuchen Chen, Ikeda, Ishihara, J. Michael McCaffery, Kageyama, Kasahara, Lopaschuk, Losón, Mishra, Mohit Jain, Otera, Papanicolaou, Postic, Qi, Sadate-Ngatchou, Shamseldin, Shuxun Ren, Song, Vamsi Mootha, Wakabayashi, Waterham, Züchner   +38 more
core   +4 more sources

Organelle Localization‐Induced Bio‐Orthogonal Polymerization (OLIBOP) for Photostable Super‐Resolution Live‐Cell Imaging

Advanced Healthcare Materials, EarlyView.
Organelle localization‐induced biorthogonal polymerization enables direct synthesis of photostable poly‐AIEgens within targeted organelles for super‐resolution live‐cell imaging. ABSTRACT Real‐time monitoring of dynamic biological processes demands fluorescent probes that can withstand prolonged light exposure without photobleaching—a critical ...
Gaeun Park, Sangpil Kim, Dohyun Kim, Injun Hwang, Ja‐Hyoung Ryu   +4 more
wiley   +1 more source

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Redox Biology, 2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Antonio Hernandez-Mijares, Milagros Rocha, Victor M. Victor   +5 more
doaj   +1 more source

Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. [PDF]

PLoS ONE, 2012
Evasion of apoptosis is implicated in almost all aspects of cancer progression, as well as treatment resistance. In this study, resistance to apoptosis was identified in tumorigenic lung epithelial (A549) cells as a consequence of defects in ...
Kelly Jean Thomas, Marty R Jacobson
doaj   +1 more source

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]

, 2014
In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V, Bertrand, Mathieu, Bruggeman, Inge, Dondelinger, Yves, Gonçalves, Amanda, Goossens, Vera, Grootjans, Sasker, Remijsen, Quinten, Roelandt, Ria, Takahashi, Nozomi, Van den Haute, C, Vanden Berghe, Tom, Vandenabeele, Peter, Vanlangenakker, Nele   +13 more
core   +3 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies

Antioxidants, 2023
Mitochondrial fission is a crucial process in maintaining metabolic homeostasis in normal physiology and under conditions of stress. Its dysregulation has been associated with several metabolic diseases, including, but not limited to, obesity, type 2 ...
Tianzheng Yu, Li Wang, Lei Zhang, Patricia A. Deuster   +3 more
doaj   +1 more source

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster [PDF]

, 2017
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing.
A Rana, A Tanaka, AC Poole, AC Poole, AM Pickrell, AS Rambold, B DuBoff, C Lopez-Otin, CC Yang, CQ Scheckhuber, D Mathur, D Ryu, DC Chan, DC David, DC Rubinsztein, DJ Klionsky, DP Narendra, DR Green, DW Walker, E Beregi, E Dambroise, E Lionaki, E Owusu-Ansah, E Smirnova, E Ziviani, ES Vincow, F Demontis, G Ashrafi, G Twig, G Twig, GD Cartee, H Abeliovich, H Deng, H Nakatogawa, I Pimenta de Castro, IP Castro de, J Durieux, J Park, J Yun, JM Copeland, JP Leduc-Gaudet, K Kavanagh, K Mao, K Palikaras, L Buhlman, L Partridge, L Poirier, M Frank, M Kaeberlein, M Manczak, M Rera, M Rera, M Schrader, MJ Drummond, N Sun, N Sun, N Thevaranjan, NC Chan, P Reis-Rodrigues, R Coleman, R Kandimalla, RH Houtkooper, RJ Youle, RJ Youle, S Geisler, S Gelino, S Hoppins, S Iqbal, SE Wohlgemuth, WW Ja, X Wang, Y Wang, Y Yang   +72 more
core   +6 more sources