Results 1 to 10 of about 1,253,804 (210)
Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
exaly +3 more sources
Redox Biology, 2022 Imbalanced mitochondrial dynamics including inhibited mitochondrial fusion is associated with cardiac dysfunction as well as tumorigenesis. This study sought to explore the effects of promoting mitochondrial fusion on doxorubicin(Dox)-induced ...
Feng Fu, Mingge Ding, Feng Fu
exaly +3 more sources
Mitochondrial Fusion Is Essential for Steroid Biosynthesis [PDF]
PLoS ONE, 2012 Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve ...
Cecilia Poderoso +2 more
exaly +2 more sources
BMC Biology, 2021 Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu +6 more
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Mitochondrial morphological features are associated with fission and fusion events. [PDF]
PLoS ONE, 2014 Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate +4 more
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MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion
EMBO Reports, 2023 Fusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and 2 (MFN2), yet the differential contribution of each of these proteins is less understood.
Andres Goldman +5 more
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Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. [PDF]
PLoS ONE, 2011 Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change.
Pinwei Huang +2 more
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Mitochondrial fusion and ERK activity regulate steroidogenic acute regulatory protein localization in mitochondria. [PDF]
PLoS ONE, 2014 The rate-limiting step in the biosynthesis of steroid hormones, known as the transfer of cholesterol from the outer to the inner mitochondrial membrane, is facilitated by StAR, the Steroidogenic Acute Regulatory protein.
Alejandra Duarte +3 more
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Cells, 2022 Mitochondrial fusion is essential to mitochondrial fitness and cellular health. Neurons of patients with genetic neurodegenerative diseases often exhibit mitochondrial fragmentation, reflecting an imbalance in mitochondrial fusion and fission ...
Xiawei Dang +5 more
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Modulating mitofusins to control mitochondrial function and signaling
Nature Communications, 2022 Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality.
Emmanouil Zacharioudakis +20 more
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