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Mitochondrial fusion is required for regulation of mitochondrial DNA replication.
PLoS Genetics, 2019 Mitochondrial dynamics is an essential physiological process controlling mitochondrial content mixing and mobility to ensure proper function and localization of mitochondria at intracellular sites of high-energy demand.
Eduardo Silva Ramos +12 more
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Mitochondrial Fusion: The Machineries In and Out [PDF]
Trends in Cell Biology, 2021 Mitochondria are highly dynamic organelles that constantly undergo fission and fusion. Disruption of mitochondrial dynamics undermines their function and causes several human diseases. The fusion of the outer (OMM) and inner mitochondrial membranes (IMM) is mediated by two classes of dynamin-like protein (DLP): mitofusin (MFN)/fuzzy onions 1 (Fzo1) and
Song Gao, Junjie Hu
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Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
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Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]
Toxicology, 2017 Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel Meyer, Anthony L Luz
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Redox Biology, 2022 Imbalanced mitochondrial dynamics including inhibited mitochondrial fusion is associated with cardiac dysfunction as well as tumorigenesis. This study sought to explore the effects of promoting mitochondrial fusion on doxorubicin(Dox)-induced ...
Mingge Ding +12 more
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Mitochondrial fusion protein: a new therapeutic target for lung injury diseases [PDF]
Frontiers in PhysiologyMitochondria are essential organelles responsible for cellular energy supply. The maintenance of mitochondrial structure and function relies heavily on quality control systems, including biogenesis, fission, and fusion. Mitochondrial fusion refers to the
Guiyang Jia +4 more
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Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
David Chan
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Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells [PDF]
Veterinary SciencesBackground: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xiuhan Xu +4 more
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Mitochondria- and ER-associated actin are required for mitochondrial fusion [PDF]
Nature CommunicationsMitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove ...
Priya Gatti +4 more
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Mitochondrial fusion is essential for steroid biosynthesis. [PDF]
PLoS ONE, 2012 Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve ...
Alejandra Duarte +6 more
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