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Mitochondrial fusion is required for regulation of mitochondrial DNA replication.
PLoS Genetics, 2019 Mitochondrial dynamics is an essential physiological process controlling mitochondrial content mixing and mobility to ensure proper function and localization of mitochondria at intracellular sites of high-energy demand.
Eduardo Silva Ramos +12 more
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Mitochondrial fusion is essential for steroid biosynthesis. [PDF]
PLoS ONE, 2012 Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve ...
Alejandra Duarte +6 more
doaj +5 more sources
Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders
Membranes, 2022 Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi +2 more
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Redox Biology, 2022 Imbalanced mitochondrial dynamics including inhibited mitochondrial fusion is associated with cardiac dysfunction as well as tumorigenesis. This study sought to explore the effects of promoting mitochondrial fusion on doxorubicin(Dox)-induced ...
Mingge Ding +2 more
exaly +3 more sources
Mitochondrial fusion protein: a new therapeutic target for lung injury diseases. [PDF]
Front PhysiolMitochondria are essential organelles responsible for cellular energy supply. The maintenance of mitochondrial structure and function relies heavily on quality control systems, including biogenesis, fission, and fusion. Mitochondrial fusion refers to the
Jia G, Song E, Huang Q, Chen M, Liu G.
europepmc +2 more sources
Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells. [PDF]
Vet SciBackground: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xu X, Zhao Y, Zhu Z, Wen W, Li X.
europepmc +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003 Mitochondrial fusion has been observed in a great variety of organisms from yeast to man. It serves to mix and unify the mitochondrial compartment and plays roles in cellular aging, cell development, energy dissipation and mitochondrial DNA inheritance. Large GTPases in the mitochondrial outer membrane, termed Fzo or mitofusins, have been identified as
Westermann, Benedikt
openaire +3 more sources
Mitochondria- and ER-associated actin are required for mitochondrial fusion. [PDF]
Nat CommunMitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove ...
Gatti P +4 more
europepmc +2 more sources
Mitochondrial fusion induced by Mdivi-1 and leflunomide alters cell proliferation and viability, steroidogenesis and oxidative stress in chicken ovarian cells. [PDF]
Poult SciMitochondria are key organelles that regulate energy production, oxidative stress, and steroidogenesis. They are highly dynamic, continuously undergoing fusion and fission.
Couty N +6 more
europepmc +2 more sources
Mitochondrial Fusion Proteins and Human Diseases [PDF]
Neurology Research International, 2013 Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell.
Michela Ranieri +7 more
doaj +4 more sources