Results 1 to 10 of about 256,048 (301)

Mitochondrial fusion protein: a new therapeutic target for lung injury diseases [PDF]

Frontiers in Physiology
Mitochondria are essential organelles responsible for cellular energy supply. The maintenance of mitochondrial structure and function relies heavily on quality control systems, including biogenesis, fission, and fusion. Mitochondrial fusion refers to the
Guiyang Jia, Erqin Song, Qianxia Huang, Miao Chen, Guoyue Liu   +4 more
doaj   +2 more sources

A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators [PDF]

BMC Biology, 2010
Background Mitochondria are highly dynamic organelles whose morphology and position within the cell is tightly coupled to metabolic function. There is a limited list of essential proteins that regulate mitochondrial morphology and the mechanisms that ...
Bilodeau Patricia, Soubeyrand Sébastien, Xu Liqun, Choi Seok-Yong, Huang Huiyan, Schauss Astrid C, Zunino Rodolfo, Rippstein Peter, Frohman Michael A, McBride Heidi M   +9 more
doaj   +2 more sources

Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells [PDF]

Veterinary Sciences
Background: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xiuhan Xu, Yuan Zhao, Zhenbang Zhu, Wei Wen, Xiangdong Li   +4 more
doaj   +2 more sources

Mitochondria- and ER-associated actin are required for mitochondrial fusion [PDF]

Nature Communications
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove ...
Priya Gatti, Cara Schiavon, Julien Cicero, Uri Manor, Marc Germain   +4 more
doaj   +2 more sources

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction [PDF]

Frontiers in Aging Neuroscience, 2015
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission.
Antonio eZorzano, Marc eClaret
doaj   +3 more sources

Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders

Membranes, 2022
Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission
Mode Al Ojaimi, Azza Salah, Ayman W. El-Hattab   +2 more
doaj   +1 more source

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries

BMC Biology, 2021
Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch

Redox Biology, 2022
Imbalanced mitochondrial dynamics including inhibited mitochondrial fusion is associated with cardiac dysfunction as well as tumorigenesis. This study sought to explore the effects of promoting mitochondrial fusion on doxorubicin(Dox)-induced ...
Mingge Ding, Rui Shi, Shuli Cheng, Man Li, Dema De, Chaoyang Liu, Xiaoming Gu, Juan Li, Shumiao Zhang, Min Jia, Rong Fan, Jianming Pei, Feng Fu   +12 more
doaj   +1 more source

Mitochondrial morphological features are associated with fission and fusion events. [PDF]

PLoS ONE, 2014
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion.
Laura M Westrate, Jeffrey A Drocco, Katie R Martin, William S Hlavacek, Jeffrey P MacKeigan   +4 more
doaj   +1 more source

Mitochondrial fusion is essential for steroid biosynthesis. [PDF]

PLoS ONE, 2012
Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve ...
Alejandra Duarte, Cecilia Poderoso, Mariana Cooke, Gastón Soria, Fabiana Cornejo Maciel, Vanesa Gottifredi, Ernesto J Podestá   +6 more
doaj   +1 more source