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In vitro assays to monitor membrane fusion [PDF]
Frontiers in Cell and Developmental BiologyMembrane fusion is essential to maintain eukaryotic life. Fusion is tightly regulated and relies on a complex network of protein tethers and lipid interactions.
Hunter J. Madison, Adam L. Yokom
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From Population Averaging to Single Event Resolution: Evolution of Sensing Platforms for Membrane Fusion [PDF]
SensorsMembrane fusion is fundamental to intracellular transport and signal transduction, with its dysregulation implicated in various diseases. Deciphering its transient, microscale dynamics requires advanced sensing technologies.
Yazhuo Feng +4 more
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SNAREs — engines for membrane fusion [PDF]
Nature Reviews Molecular Cell Biology, 2006 Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair ...
Reinhard Jahn +2 more
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Alphavirus Entry and Membrane Fusion
Viruses, 2010 The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell.
Margaret Kielian +2 more
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Nature Structural & Molecular Biology, 2008 Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis.
William, Wickner, Randy, Schekman
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Membrane fusion and budding. [PDF]
Biophys JAnantharam A, Knowles MK, Wu LG.
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Simulation and prediction of membrane fusion dynamics
Theoretical and Applied Mechanics Letters, 2022 Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come ...
Zhi Zheng, Shouqin Lü, Mian Long
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Cell, 2003 Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together
Jahn, R., Lang, T., Suedhof, T.
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The Effects of Regulatory Lipids on Intracellular Membrane Fusion Mediated by Dynamin-Like GTPases
Frontiers in Cell and Developmental Biology, 2020 Membrane fusion mediates a number of fundamental biological processes such as intracellular membrane trafficking, fertilization, and viral infection. Biological membranes are composed of lipids and proteins; while lipids generally play a structural role,
Yeojin Moon, Youngsoo Jun
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A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization
Biomolecules, 2023 Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi +5 more
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