Prediction of β-barrel membrane proteins by searching for restricted domains [PDF]
, 2005 BACKGROUND: The identification of beta-barrel membrane proteins out of a genomic/proteomic background is one of the rapidly developing fields in bioinformatics. Our main goal is the prediction of such proteins in genome/proteome wide analyses.
Mirus, O. +5 more
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Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes
Cell Reports, 2021 Summary: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity. Multiple GLP-1R agonists have entered into clinical trials,
Xin Zhang +5 more
doaj +1 more source
Studies on interactions of exported "plasmodium falciparum" membrane proteins [PDF]
, 2014 Responsible for about 700’000 annual deaths worldwide, malaria today is still one of the major health problems in developing countries. The most deadly form of human malaria called malaria tropica is caused by the apicomplexan parasite Plasmodium ...
Dietz, Olivier
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Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]
, 2005 Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
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Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon [PDF]
, 1999 The topology of multispanning membrane proteins in the mammalian endoplasmic reticulum is thought to be dictated primarily by the first hydrophobic sequence.
Martin Spiess +5 more
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The road not taken: Less traveled roads from the TGN to the plasma membrane [PDF]
, 2015 : The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma
Anne Spang, Spang, Anne
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PELDOR/DEER: An electron paramagnetic resonance method to study membrane proteins in lipid bilayers.
, 2021 Every membrane protein is involved in close interactions with the lipid environment of cellular membranes. The annular lipids, that are in direct contact with the polypeptide, can in principle be seen as an integral part of its structure, akin to the ...
Beis, Konstantinos +7 more
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Structural characterisation of outer membrane proteins from Borrelia burgdorferi sensu lato by small-angle X-ray scattering [PDF]
, 2016 Forming the interface between the bacterial cell and the host, the outer membrane of Borrelia is known to play a key role in pathogenicity. Although Borrelia burgdorferi sensu lato are considered to be Gram-negative, their outer membrane is unique ...
Stejskal, Lenka
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eLife, 2023 Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic +23 more
doaj +1 more source
Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]
, 2004 Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry +7 more
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