Results 1 to 10 of about 1,038,801 (318)

Molecular dynamics simulation of an entire cell [PDF]

, 2023
The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell’s components with atomic resolution. In contrast to their real-world counterparts, computational microscopes are currently on the brink of meeting this challenge.
Marrink, Siewert J; id_orcid, Stevens, Jan A; id_orcid, Stevens, Jan A., Jan A. Stevens, Stevens, Jan A, Thornburg, Zane R, Gilbert, Benjamin R., Siewert J. Marrink, Benjamin R. Gilbert, Gilbert, Benjamin R, Marrink, Siewert J, van Tilburg, P. A. Marco, Zane R. Thornburg, Brier, Troy A., Melanie König, Luthey-Schulten, Zaida, Marrink, Siewert J., P. A. Marco van Tilburg, König, Melanie; id_orcid, Troy A. Brier, Zaida Luthey-Schulten, Thornburg, Zane R., Brier, Troy A, van Tilburg, P A Marco, Fabian Grünewald, König, Melanie, Grünewald, Fabian   +26 more
core   +1 more source

Phylogenetic characterization of canine distemper virus from stray dogs in Kathmandu Valley

Virology Journal, 2023
Canine distemper is a highly contagious, often fatal disease caused by canine distemper virus (CDV) in domestic dogs and wild carnivores. The virus has caused mass epidemics in both wild and captive carnivores of high conservation value such as tigers ...
Prajwol Manandhar, Rajindra Napit, Saman M Pradhan, Pragun G Rajbhandari, Jessie A Moravek, Pranav R Joshi, Rima D Shrestha, Dibesh Karmacharya   +7 more
doaj   +1 more source

Tracing multiple scattering trajectories for deep optical imaging in scattering media

Nature Communications, 2023
Multiple light scattering hampers imaging objects in complex scattering media. Approaches used in real practices mainly aim to filter out multiple scattering obscuring the ballistic waves that travel straight through the scattering medium.
Sungsam Kang, Yongwoo Kwon, Hojun Lee, Seho Kim, Jin Hee Hong, Seokchan Yoon, Wonshik Choi   +6 more
doaj   +1 more source

MOLECULAR REPLICATOR DYNAMICS [PDF]

Advances in Complex Systems, 2003
Template-dependent replication at the molecular level is the basis of reproduction in nature. A detailed understanding of the peculiarities of the chemical reaction kinetics associated with replication processes is therefore an indispensible prerequisite for any understanding of evolution at the molecular level. Networks of interacting self-replicating
Bärbel M. R. Stadler, Peter F. Stadler
openaire   +3 more sources

Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness

Scientific Reports, 2022
Functional buffering that ensures biological robustness is critical for maintaining tissue homeostasis, organismal survival, and evolution of novelty.
Hao-Kuen Lin, Jen-Hao Cheng, Chia-Chou Wu, Feng-Shu Hsieh, Carolyn Dunlap, Sheng-hong Chen   +5 more
doaj   +1 more source

Antimicrobial drug resistant non-typhoidal Salmonella enterica in commercial poultry value chain in Chitwan, Nepal

One Health Outlook, 2020
Background Antimicrobial resistance (AMR) among bacterial pathogens is a fast-growing public health concern. AMR in non-typhoidal Salmonella serovars (NTS) among food animals is of special concern as this may transmit resistant pathogens to humans during
Amy Nelson, Sulochana Manandhar, Juliana Ruzante, Arrogya Gywali, Bimala Dhakal, Santosh Dulal, Rupendra Chaulagai, Sameer M. Dixit   +7 more
doaj   +1 more source

Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

Nature Communications, 2023
A eukaryotic cell is a microscopic world within which efficient material transport is essential. Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment remains poorly understood.
Jin-Sung Park, Il-Buem Lee, Hyeon-Min Moon, Seok-Cheol Hong, Minhaeng Cho   +4 more
doaj   +1 more source

Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin

Nature Communications, 2023
The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull ...
Yongwoo Kwon, Jin Hee Hong, Sungsam Kang, Hojun Lee, Yonghyeon Jo, Ki Hean Kim, Seokchan Yoon, Wonshik Choi   +7 more
doaj   +1 more source

The molecular dynamics of MDM2 [PDF]

Cell Cycle, 2010
The pro-oncogenic signals of a vast number of anti-cancer drug targets are mediated by protein-protein interactions. This has made such targets less attractive to classic drug discovery programmes. New paradigms in the protein science field have revealed, however, that many protein-protein complexes are stabilized by an interaction between an ...
Judith, Nicholson, Ted R, Hupp
openaire   +2 more sources

High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix

Light: Science & Applications, 2022
Compressed time-reversal matrix microscopy was developed for high-throughput volumetric adaptive optical imaging, enabling aberration-free visualization of myelinated axons in a mouse brain with high volumetric resolution.
Hojun Lee, Seokchan Yoon, Pascal Loohuis, Jin Hee Hong, Sungsam Kang, Wonshik Choi   +5 more
doaj   +1 more source