Results 41 to 50 of about 2,118,036 (319)
Frontiers in Endocrinology, 2021 Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting.
Kaleeckal G. Harikumar +14 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai +4 more
wiley +1 more source
Diffusion of Integral Membrane Proteins in Protein-Rich Membranes
The Journal of Physical Chemistry Letters, 2017 The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbrück (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D ∝ ln(1/R).
Matti Javanainen +3 more
openaire +5 more sources
Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
Frontiers in Molecular Biosciences, 2021 Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti +7 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi +6 more
wiley +1 more source
Tracking Membrane Protein Association in Model Membranes
PLoS ONE, 2009 Membrane proteins are essential in the exchange processes of cells. In spite of great breakthrough in soluble proteins studies, membrane proteins structures, functions and interactions are still a challenge because of the difficulties related to their hydrophobic properties.
Reffay, Myriam +7 more
openaire +8 more sources
A novel and selective fluorescent ligand for the study of adenosine A2B receptors
Pharmacology Research & PerspectivesFluorescent ligands have proved to be powerful tools in the study of G protein‐coupled receptors in living cells. Here we have characterized a new fluorescent ligand PSB603‐BY630 that has high selectivity for the human adenosine A2B receptor (A2BR).
Foteini Patera +8 more
doaj +1 more source
Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein
Frontiers in PharmacologyIntroductionThe β2-adrenoceptor (β2AR) is a class A G protein-coupled receptor (GPCR). It is therapeutically relevant in asthma and chronic obstructive pulmonary disease (COPD), where β2AR agonists relieve bronchoconstriction.
Clare R. Harwood +19 more
doaj +1 more source
TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
Nature Communications, 2022 TLR3 plays a crucial role in anti-viral immune response by recognizing RNAs produced during virus infection. Here, the authors determine a high resolution structure of the activated cluster of TLR3.
Chan Seok Lim +6 more
doaj +1 more source
Characterization of an OmpA-like outer membrane protein of the acidophilic iron-oxidizing bacterium, Acidithiobacillus ferrooxidans [PDF]
, 2011 An OmpA family protein (FopA) previously reported as one of the major outer membrane proteins of an acidophilic iron-oxidizing bacterium Acidithiobacillus ferrooxidans was characterized with emphasis on the modification by heat and the interaction with ...
Kamimura, Kazuo +9 more
core +1 more source