Results 21 to 30 of about 10,936,171 (356)

Super-Resolution Imaging Approaches for Quantifying F-Actin in Immune Cells

Frontiers in Cell and Developmental Biology, 2021
Immune cells comprise a diverse set of cells that undergo a complex array of biological processes that must be tightly regulated. A key component of cellular machinery that achieves this is the cytoskeleton.
Evelyn Garlick, Evelyn Garlick, Steven G. Thomas, Steven G. Thomas, Dylan M. Owen, Dylan M. Owen   +5 more
doaj   +1 more source

Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells

iScience, 2023
Summary: E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in ...
Lydia Ogrodzinski, Simon Platt, Joelle Goulding, Cameron Alexander, Tracy D. Farr, Jeanette Woolard, Stephen J. Hill, Laura E. Kilpatrick   +7 more
doaj   +1 more source

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases

Open Biology, 2022
Protein S-acylation, more commonly known as protein palmitoylation, is a biological process defined by the covalent attachment of long chain fatty acids onto cysteine residues of a protein, effectively altering the local hydrophobicity and influencing ...
R. Elliot Murphy, Anirban Banerjee
doaj   +1 more source

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Nature Reviews Molecular Cell Biology, 2017
E. Sezgin, I. Levental, S. Mayor, C. Eggeling   +3 more
semanticscholar   +3 more sources

Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]

, 2013
Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U, Han, Seong Kyu, Kim, Sanguk, Nam, Hyun-Jun   +3 more
core   +3 more sources

Membrane proteins and proteomics: Love is possible, but so difficult [PDF]

, 2009
Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with ...
Adessi, Aebersold, Aivaliotis, Aivaliotis, Alla, Ames, Babu, Bagshaw, Bell, Berlanda-Scorza, Berven, Bierczynska-Krzysik, Bisle, Bjellqvist, Bunai, Bunai, Burré, Buxbaum, Casey, Chevallet, Chevallet, Connolly, Coughenour, Cutillas, Devreese, Eravci, Everberg, Felsted, Ferro, Gatlin, Ghosh, Gyenes, Görg, Hagan, Hahne, Hartinger, Helling, Henningsen, Henzel, Hisabori, Hjelmeland, Huang, Huang, James, Jun, Lasonder, Lescuyer, Liberatori, Lopez, Low, Luche, Lyubimova, Lüddens, MacFarlane, MacFarlane, Matsudaira, McDonough, Miguet, Moebius, Molloy, Molloy, Nandakumar, Natera, Navarre, Ong, Papasotiriou, Pappin, Patton, Pedersen, Peng, Perdew, Phadke, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rais, Rubin, Santoni, Santoni, Schindler, Schirle, Schägger, Siroy, Speers, Sweetnam, Switzer, Tastet, Taylor, Towbin, Veith, Washburn, Werner, Wilkins, Williams, Williams, Williams, Wittig, Witzmann, Wu, Yates, Ying, Zahedi   +103 more
core   +5 more sources

Reverse-topology membrane scission by the ESCRT proteins

Nature Reviews Molecular Cell Biology, 2016
J. Schöneberg, Il-Hyung Lee, J. Iwasa, J. Hurley   +3 more
semanticscholar   +3 more sources

DOCKGROUND Membrane Protein-Protein Set [PDF]

PLOS ONE, 2021
ABSTRACTMembrane proteins play essential role in cellular mechanisms. Despite that and the major progress in experimental structure determination, they are still significantly underrepresented in Protein Data Bank. Thus, computational approaches to protein structure determination, which are important in general, are especially valuable in the case of ...
Ian Kotthoff, Petras J. Kundrotas, Ilya A. Vakser   +2 more
openaire   +4 more sources

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes

Cell Reports, 2021
Summary: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity. Multiple GLP-1R agonists have entered into clinical trials,
Xin Zhang, Matthew J. Belousoff, Yi-Lynn Liang, Radostin Danev, Patrick M. Sexton, Denise Wootten   +5 more
doaj   +1 more source

Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins

bioRxiv, 2017
Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Understanding the lateral organization principles of these complex mixtures is essential for life and health.
V. Corradi, E. Mendez-Villuendas, H. Ingólfsson, Ruo-Xu Gu, Iwona Siuda, Manuel N. Melo, Anastassiia Moussatova, Lucien J. DeGagné, Besian I. Sejdiu, Gurpreet Singh, T. Wassenaar, Karelia Delgado Magnero, S. Marrink, D. Tieleman   +13 more
semanticscholar   +1 more source