Results 21 to 30 of about 4,599,169 (256)
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
, 1993 Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert +5 more
core +2 more sources
eLife, 2023 Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR ...
Ziva Vuckovic +23 more
doaj +1 more source
Informing β-cell regeneration strategies using studies of heterogeneity
Molecular Metabolism, 2019 Background: Current therapeutic strategies for type 1 (T1DM) and type 2 diabetes mellitus (T2DM) rely on increasing or substituting endogenous insulin secretion in combination with lifestyle changes.
Daniela Nasteska +3 more
doaj +1 more source
Frontiers in Immunology, 2022 IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in various ...
Dehan Comez +12 more
doaj +1 more source
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery
Cell Reports, 2020 Summary: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases.
Carlos M. Guardia +10 more
doaj +1 more source
Nature Communications, 2020 Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 ...
Julia Ast +25 more
doaj +1 more source
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Julia Ast +25 more
doaj +1 more source
Alignment of helical membrane protein sequences using AlignMe [PDF]
, 2013 Few sequence alignment methods have been designed specifically for integral membrane proteins, even though these important proteins have distinct evolutionary and structural properties that might affect their alignments.
René Staritzbichler +19 more
core +2 more sources
High-throughput Site-directed Scanning Mutagenesis Using a Two-fragment PCR Approach
Bio-Protocol, 2020 Site-directed scanning mutagenesis is a useful tool applied in studying protein function and designing proteins with new properties, such as increased stability or enzymatic activity. Creating a systematic library of hundreds of site-directed mutants is
Franziska Heydenreich +3 more
doaj +1 more source
Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon [PDF]
, 1999 The topology of multispanning membrane proteins in the mammalian endoplasmic reticulum is thought to be dictated primarily by the first hydrophobic sequence.
Martin Spiess +8 more
core +1 more source